Product Information
Name:Val-Ala-PAB
Controlled Product
Synonyms:
- L-Valyl-N-[4-(hydroxymethyl)phenyl]-L-alaninamide
Brand:TRC
Description:Applications Val-Ala-PAB is a building block in the synthesis of Tesirine (a.k.a. SG3249), a clinical antibody-drug conjugate pyrrolobenzodiazepine dimer payload. Reagent in the preparation of pyrrolobenzodiazepine dimers and their antibody conjugates containing peptide linkers useful for treating proliferative including cancer.References Dimasi, N., et al.: Mol. Pharm., 14, 1501 (2017); Howard, P. W., et al.: PCT Int. Appl. (2011), WO 2011130598 A1 20111020
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Chemical properties
Molecular weight:293.36
Formula:C15H23N3O3
Color/Form:Neat
InChI:InChI=1S/C15H23N3O3/c1-9(2)13(16)15(21)17-10(3)14(20)18-12-6-4-11(8-19)5-7-12/h4-7,9-10,13,19H,8,16H2,1-3H3,(H,17,21)(H,18,20)/t10-,13-/m0/s1
InChI key:InChIKey=NNWYWNRCBPYLML-GWCFXTLKSA-N
SMILES:CC(C)[C@H](N)C(=O)N[C@@H](C)C(=O)Nc1ccc(CO)cc1
Technical inquiry about: Val-Ala-PAB
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