D-Valsartan Benzyl Ester

CAS: 1894176-48-7

Ref. TR-V095763

Product Information

• Name: D-Valsartan Benzyl Ester
• Synonyms: benzyl 3-methyl-2-[pentanoyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]butanoate
• CAS: 1894176-48-7

Description

Applications D-Valsartan Benzyl Ester is an intermediate in the synthesis of ent-Valsartan (Valsartan USP Related Compound A) (V095755), which is the (R)-enantiomer of Valsartan (V095750), which is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.
References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994); Corea, L., et al.: Clin. Pharmacol. Ther., 60, 341 (1996), Satana, E;., et al.: J. Pharm. Biomed. Anal., 25, 1009 (2001), Sironi, L., et al.: Hypertension, 37, 961 (2001),

• Brand: TRC

Chemical properties

• Molecular weight: 525.641
• Formula: C₃₁H₃₅N₅O₃
• Color/Form: Neat
• InChI: InChI=1S/C31H35N5O3/c1-4-5-15-28(37)36(29(22(2)3)31(38)39-21-24-11-7-6-8-12-24)20-23-16-18-25(19-17-23)26-13-9-10-14-27(26)30-32-34-35-33-30/h6-14,16-19,22,29H,4-5,15,20-21H2,1-3H3,(H,32,33,34,35)
• InChI key: InChIKey=VXKKFWDUSKMRNO-UHFFFAOYSA-N
• SMILES: CCCCC(=O)N(Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1)C(C(=O)OCc1ccccc1)C(C)C