Verazide

CAS: 93-47-0

Ref. TR-V127965

Product Information

• Name: Verazide
• Synonyms: [(3,4-Dimethoxyphenyl)methylene]hydrazide 4-Pyridinecarboxylic Acid, Veratrylidenehydrazide Isonicotinic Acid, 1-Isonicotinoyl-2-veratrylidenehydrazine, 3,4-Dimethoxybenzaldehyde Isonicotinoylhydrazone, NSC 180261, Nicotazide, N'-Veratrylideneisoniazid, Veratraldehyde Isonicotinoylhydrazone, Verazina, 2-[(3,4-Dimethoxyphenyl)methylene]hydrazide, 4-Pyridinecarboxylic Acid, Verazide [INN:BAN], 1-Isonicotinoyl-2-verotrylidenhydrazin, N'-Veratryliden-isonicotinohydrazid, Nsc 180261, Unii-Xo8D6I4I5L, Verazidum, N'-(3,4-dimethoxybenzylidene)pyridine-4-carbohydrazide

Description

Applications Verazide is derived from Isoniazid (I821450), which is an antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
References Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977), Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)

• Brand: TRC

Chemical properties

• Molecular weight: 285.298
• Formula: C₁₅H₁₅N₃O₃
• Color/Form: Neat
• InChI: InChI=1S/C15H15N3O3/c1-20-13-4-3-11(9-14(13)21-2)10-17-18-15(19)12-5-7-16-8-6-12/h3-10H,1-2H3,(H,18,19)/b17-10+
• InChI key: InChIKey=HPXIKMBHOXLFOR-LICLKQGHSA-N
• SMILES: COc1ccc(/C=N/NC(=O)c2ccncc2)cc1OC