Product Information
Name:XL518
Controlled Product
Synonyms:
- [3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]methanone
- GDC 0973
- XL 518
- Cobimetinib
- Cotellic
Brand:TRC
Description:Applications A potent, selective, orally bioavailable inhibitor of MEK1, a component of the RAS/RAF/MEK/ERK pathway. It inhibits proliferation and stimulates apoptosis in a variety of human tumor cell lines. In preclinical xenograft models, oral administration of XL518 results in sustained inhibition of pERK in tumor tissue, but not brain tissue, leading to tumor growth inhibition and regression at well tolerated doses.References Rosen, L.S. et al.: J. Clin. Oncol., 26, 14585 (2008);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:531.31
Formula:C21H21F3IN3O2
Color/Form:White To Off-White
InChI:InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2/t17-/m0/s1
InChI key:InChIKey=BSMCAPRUBJMWDF-KRWDZBQOSA-N
SMILES:O=C(c1ccc(F)c(F)c1Nc1ccc(I)cc1F)N1CC(O)([C@@H]2CCCCN2)C1
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