Product Information
Name:Zaprinast
Controlled Product
Synonyms:
- 5-(2-propoxyphenyl)-1,4-dihydrotriazolo[4,5-d]pyrimidin-7-one
Brand:TRC
Description:Applications A selective inhibitor of cyclic-GMP phosphodiesterase (PDE V, calmodulin insensitive). Since cGMP mediates the vasorelaxant action of nitric oxide, as well as the natriuretic and diuretic effect of atrial natriuretic factor (ANF) through the activation of PKG (cGMP dependent protein kinase), such inhibitors may display vasodilating, relaxant, and diuretic effects. These compounds may prove useful in treating hypertension and congestive heart failure.References Burns, F., et al.: Biochem. J., 238, 487 (1992), Lugnier, C., et al.: Am. J. Physiol., 262, H654 (1992),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:271.27
Formula:C13H13N5O2
Color/Form:Neat
InChI:InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
InChI key:InChIKey=REZGGXNDEMKIQB-UHFFFAOYSA-N
SMILES:CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1
Technical inquiry about: Zaprinast
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