Product Information
Name:ZM 447439
Controlled Product
Synonyms:
- Benzamide
- N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-
- N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
- N-(4-Benzamidophenyl)-6-methoxy-7-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
- N-(4-Benzamidophenyl)-6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinamine
Brand:TRC
Description:Applications It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.References Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:513.59
Formula:C29H31N5O4
Color/Form:Neat
InChI:InChI=1S/C29H31N5O4/c1-36-26-18-24-25(19-27(26)38-15-5-12-34-13-16-37-17-14-34)30-20-31-28(24)32-22-8-10-23(11-9-22)33-29(35)21-6-3-2-4-7-21/h2-4,6-11,18-20H,5,12-17H2,1H3,(H,33,35)(H,30,31,32)
InChI key:InChIKey=OGNYUTNQZVRGMN-UHFFFAOYSA-N
SMILES:COc1cc2c(Nc3ccc(NC(=O)c4ccccc4)cc3)ncnc2cc1OCCCN1CCOCC1
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