Zofenopril Calcium Salt

CAS: 81938-43-4

Ref. TR-Z587000

Product Information

• Name: Zofenopril Calcium Salt
• Synonyms: L-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt (2:1), (4S)-, L-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, [1(R*),2a,4a]-, SQ 26991, Zofenil, Zofenopril calcium, Zoprace, (4S)-N-[3-(Benzoylsulfanyl)-2(S)-methylpropionyl]-4-(phenylsulfanyl)-L-proline calcium salt, <span class="text-smallcaps">L</span>-Proline, 1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt (2:1), (4S)-, <span class="text-smallcaps">L</span>-Proline, 1-[3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-, calcium salt, [1(R*),2α,4α]-, Sq 26991, calcium bis[(2S,4S)-1-{(2S)-2-methyl-3-[(phenylcarbonyl)sulfanyl]propanoyl}-4-(phenylsulfanyl)pyrrolidine-2-carboxylate]

Description

Applications Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Gorren, A., et al.: Biochem. J., 331, 801 (1998), Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1999), Marchand, C., et al.: Mol. Pharmacol., 64, 600 (2003), Maurin, C., et al.: J. Med. Chem., 47, 5583 (2004),

• Brand: TRC

Chemical properties

• Molecular weight: 897.17
• Formula: C₂₂H₂₂NO₄S₂·Ca
• Color/Form: Neat
• InChI: InChI=1S/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1
• SMILES: C[C@H](CSC(=O)c1ccccc1)C(=O)N1C[C@@H](Sc2ccccc2)C[C@H]1C(=O)[O-].C[C@H](CSC(=O)c1ccccc1)C(=O)N1C[C@@H](Sc2ccccc2)C[C@H]1C(=O)[O-].[Ca+2]