Zoledronic acid

CAS: 118072-93-8

Ref. TR-Z623505

Product Information

• Name: Zoledronic acid
• Synonyms: Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis- (9CI), (1-Hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid, 1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene-1,1-bisphosphonic acid, 2-(Imidazol-1-yl)-1-hydroxy-1,1'-ethylidenediphosphonic acid, Aclasta, BPH 91, CGP 42446, Orazol, Reclast, ZOL 446, Zoledronate, Zometa, Phosphonic acid, P,P'-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, Phosphonic acid, [1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, Phosphonic acid, P,P′-[1-hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis-, P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bis[phosphonic acid]

Description

Stability extremely hygroscopic
Applications Zoledronic acid induces apoptosis in osteoclasts by inhibiting enzymes of the mevalonate pathway and preventing the isoprenylation of small GTP-binding proteins such as Ras and Rho.
References Jagdev, S., et al.: Br. J. Cancer, 84, 1126 (2001); Viereck, V., et al.: Biochem. Biophys. Res. Commun., 291, 680-686.Croucher. P., et al.: J. Bone Miner. Res., 2003, 18(3), 482-492.

• Brand: TRC

Chemical properties

• Molecular weight: 272.09
• Formula: C₅H₁₀N₂O₇P₂
• Color/Form: Neat
• InChI: InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
• InChI key: InChIKey=ZFXFMGARFHRTTO-UHFFFAOYSA-N
• SMILES: COc1ccc(CC(=O)O)c(OC)c1