FAK
Os inibidores da quinase de adesão focal (FAK) têm como alvo a FAK, uma quinase envolvida na adesão celular, migração e angiogênese. A FAK é frequentemente superexpressa em tumores e contribui para a formação de novos vasos sanguíneos que fornecem nutrientes ao tumor. Inibir a FAK pode interromper esses processos, tornando os inibidores de FAK ferramentas valiosas na terapia do câncer e na pesquisa de angiogênese. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de FAK de alta qualidade para apoiar sua pesquisa em biologia celular, câncer e angiogênese.
Foram encontrados 71 produtos para "FAK".
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Ifebemtinib FA
BI-853520 FA (Ifebemtinib FA) is an orally active inhibitor of adhesion patch kinase with anticancer and antiproliferative activity for ovarian and lung cancer.Fórmula:C29H30F4N6O6Pureza:98.05% - 99.75%Cor e Forma:SolidPeso molecular:634.58FAK-IN-27
FAK-IN-27 (compound 8A) is a potent and selective inhibitor of FAK, with an IC50 of 4.968 nM. It effectively inhibits the proliferation of H1299 cells, with an IC50 of 0.28 μM, and is applicable for research in non-small cell lung cancer (NSCLC).Fórmula:C32H28ClN5O6Cor e Forma:SolidPeso molecular:613.17281FAK-IN-10
CAS:FAK-IN-10 is an inhibitor of FAK (IC50:76.3 μM).FAK-IN-10 z MCF-7 and A431 cell lines showed antitumor activity with IC50 of 4.23 and 0.78 μM, respectively.Fórmula:C15H10BrN3O2SPureza:99.86%Cor e Forma:SolidPeso molecular:376.23Defactinib analogue-1
CAS:Defactinib analogue-1 (Compound 7) serves as a ligand for the target protein FAK, and is utilized in the synthesis of PROTAC FAK degrader 1.Fórmula:C20H20F3N5O3SCor e Forma:SolidPeso molecular:467.47Anti-PTK2 Antibody (4T687)
Anti-PTK2 Antibody (4T687) is an antibody targeting PTK2. Anti-PTK2 Antibody (4T687) can be used in ELISA, IHC.Cor e Forma:Odour LiquidConteltinib tetrahydrochloride
Conteltinibtetrahydrochloride (CT-707 tetrahydrochloride) is the tetrahydrochloride form of Conteltinib. It acts as an inhibitor for FAK (IC50=1.6 nM), ALK, and Pyk2. When used in combination with Cabozantinib, Conteltinib tetrahydrochloride exhibits a synergistic antitumor effect.Fórmula:C32H49Cl4N9O3SCor e Forma:SolidPeso molecular:781.667BI-3663
CAS:BI-3663 is a selective PTK2/FAK PROTAC with cereblon ligands, degrading PTK2 (IC50: 18 nM), and shows anti-cancer properties.Fórmula:C44H42F3N7O12Pureza:98%Cor e Forma:SolidPeso molecular:917.84NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Cor e Forma:SolidPeso molecular:468.94Ref: TM-T1918
1mg46,00€2mg59,00€5mg96,00€1mL*10mM (DMSO)96,00€10mg155,00€25mg250,00€50mg358,00€100mg537,00€SU6656
CAS:SU 6656 is a selective inhibitor of Src family kinases, with IC50 of 280 nM, 20 nM, 130 nM, and 170 nM for Src, Yes, Lyn, and Fyn, respectively.Fórmula:C19H21N3O3SPureza:98.21% - 98.73%Cor e Forma:SolidPeso molecular:371.45Masitinib
CAS:Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.Fórmula:C28H30N6OSPureza:97.56% - >99.99%Cor e Forma:White SolidPeso molecular:498.64Y15
CAS:Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity,Fórmula:C6H14Cl4N4Pureza:98% - 99.32%Cor e Forma:Black SolidPeso molecular:284.01Ref: TM-T7119
1mL*10mM (DMSO)46,00€10mg48,00€25mg65,00€50mg78,00€100mg130,00€200mg178,00€500mg314,00€PF-431396
CAS:PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM).Fórmula:C22H21F3N6O3SPureza:98.83% - 99.82%Cor e Forma:Yellow SolidPeso molecular:506.5Fangchinoline
CAS:Fangchinoline (Tetrandrine B) is extracted from Stephania tetrandra S. Moore.Fórmula:C37H40N2O6Pureza:99.86% - >99.99%Cor e Forma:SolidPeso molecular:608.72AMP-945
CAS:AMP-945 is a proprietary focal adhesion kinase (FAK) inhibitor.Fórmula:C28H32F3N5O2Pureza:99.76%Cor e Forma:White SolidPeso molecular:527.58PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Fórmula:C21H20F3N7O3SHClPureza:97.08%Cor e Forma:SolidPeso molecular:543.95PF-573228
CAS:PF-573228 is an ATP-competitive FAK inhibitor. In a cell-free assay, the IC50 of FAK is 4 nM.Fórmula:C22H20F3N5O3SPureza:96.58% - 99.51%Cor e Forma:White SolidPeso molecular:491.49Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Cor e Forma:SolidPeso molecular:383.82BI-4464
CAS:BI-4464 is a highly selective ATP competitive inhibitor of PTK2/FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTACFórmula:C28H28F3N5O4Pureza:99.81%Cor e Forma:White SolidPeso molecular:555.55Batatasin III
CAS:Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancerFórmula:C15H16O3Pureza:99.16%Cor e Forma:Brown SolidPeso molecular:244.29Defactinib
CAS:Defactinib (VS-6063) is a second-generation inhibitor of FAK. Defactinib has potential antitumor activity. Cost-effective and quality-assured.Fórmula:C20H21F3N8O3SPureza:98% - 99.71%Cor e Forma:White SolidPeso molecular:510.49
