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FAK

FAK

Os inibidores da quinase de adesão focal (FAK) têm como alvo a FAK, uma quinase envolvida na adesão celular, migração e angiogênese. A FAK é frequentemente superexpressa em tumores e contribui para a formação de novos vasos sanguíneos que fornecem nutrientes ao tumor. Inibir a FAK pode interromper esses processos, tornando os inibidores de FAK ferramentas valiosas na terapia do câncer e na pesquisa de angiogênese. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de FAK de alta qualidade para apoiar sua pesquisa em biologia celular, câncer e angiogênese.

Foram encontrados 74 produtos para "FAK".

produtos por página.
  • Roslin 2 bromide
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    Roslin 2 bromide

    CAS:
    Roslin 2 bromide (Benzylhexamethylenetetramine bromide) is a p53 reactivator that disrupts the binding of FAK and p5.
    Fórmula:C13H19BrN4
    Pureza:99.34%
    Cor e Forma:Solid
    Peso molecular:311.221

    Ref: TM-T24730

  • FC 11
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    FC 11

    CAS:
    FC 11 is a reversible FAK PROTAC Degrader with DC50 of 40-370 pM and degrades pFAKtyr397 in TM3 cells within 3 hours at 100 nM.
    Fórmula:C41H42F3N13O9S
    Cor e Forma:Solid
    Peso molecular:949.91

    Ref: TM-T41164

  • Ifebemtinib
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    Ifebemtinib

    CAS:
    Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.
    Fórmula:C28H28F4N6O4
    Pureza:98.47% - 99.93%
    Cor e Forma:White Solid
    Peso molecular:588.5533

    Ref: TM-T64167

  • Logotipo do CymitQuimica
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    FAK-IN-3

    FAK-IN-3 inhibits FAK, reduces PA-1 cell migration/invasion, and tumor growth, with no major side effects.
    Fórmula:C28H28N6O4
    Cor e Forma:Solid
    Peso molecular:512.56

    Ref: TM-T63545

  • FAK-IN-23
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    FAK-IN-23

    CAS:
    FAK-IN-23 (Compound II) is an inhibitor of focal adhesion kinase (FAK).
    Fórmula:C32H38F3N5O8
    Cor e Forma:Solid
    Peso molecular:677.668

    Ref: TM-T204586

  • FAK-IN-26
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    FAK-IN-26

    CAS:
    FAK-IN-26 is a blood-brain barrier-penetrating inhibitor of Focal Adhesion Kinase (FAK) with an IC50 of 0.87 nM. It significantly reduces tumor cell viability, cancer stem cell activity, and cell migration in A549 and SKOV-3 cell lines. FAK-IN-26 exhibits potent anticancer activity, achieving tumor inhibition rates of 59.15% and 57.9% in A549 and SKOV-3 tumor mouse models, respectively.
    Fórmula:C20H19BrFN5O2
    Cor e Forma:Solid
    Peso molecular:460.30

    Ref: TM-T207475

  • OXA-11
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    OXA-11

    CAS:
    OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.
    Fórmula:C37H49F3N7O5P
    Pureza:98.70% - 99.20%
    Cor e Forma:White Solid
    Peso molecular:759.8

    Ref: TM-T28277

  • FAK-IN-21
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    FAK-IN-21

    CAS:
    FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.
    Fórmula:C22H22F2N8O3S
    Cor e Forma:Solid
    Peso molecular:516.52

    Ref: TM-T201079

  • FAK inhibitor 6
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    FAK inhibitor 6

    CAS:
    Compound 26F: potent enzyme inhibitor (IC50=28.2nM), low cytotoxicity (IC50=3.32μM), induces dose-dependent apoptosis in MDA-MB-231, blocks G0/G1 phase.
    Fórmula:C25H24FN5O2S
    Cor e Forma:Solid
    Peso molecular:477.55

    Ref: TM-T63123

  • Logotipo do CymitQuimica
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    FAK activator-1

    CAS:
    FAKactivator-1 (5aHCl) is a compound that functions as a FAK activator and mucosal healing inducer. It enhances the phosphorylation of FAK at the Tyr-397 site, thereby facilitating FAK activation. This agent promotes mucosal healing and is applicable in research related to gastrointestinal mucosal injury associated with non-steroidal anti-inflammatory drugs.
    Fórmula:C21H27ClF3N5O2
    Peso molecular:473.92

    Ref: TM-T217790

  • JP-153
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    JP-153

    CAS:
    JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473). JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
    Fórmula:C21H19NO5
    Cor e Forma:Solid
    Peso molecular:365.379

    Ref: TM-T206442

  • Pyk2-IN-2
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    Pyk2-IN-2

    CAS:
    Pyk2-IN-2 (compound 13j) acts as a Pyk2 inhibitor, exhibiting an IC 50 value of 0.608 μM for FAK kinase [1].
    Fórmula:C27H27N7O
    Cor e Forma:Solid
    Peso molecular:465.55

    Ref: TM-T87280

  • Logotipo do CymitQuimica
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    FAK-IN-6

    FAK-IN-6: Potent FAK inhibitor (IC50=1.415 nM), anti-cancer, for pancreatic studies.
    Fórmula:C25H31ClN5O6PS
    Cor e Forma:Solid
    Peso molecular:596.04

    Ref: TM-T64207

  • Ifebemtinib tosylate
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    Ifebemtinib tosylate

    CAS:
    Ifebemtinib (tosylate) (BI-853520 (tosylate); IN-10018 (tosylate)) is a highly selective PTK2 kinase inhibitor with anti-tumor properties. It inhibits FAK autophosphorylation in prostate cancer cells and suppresses spheroid formation and in situ tumor growth in vivo. Ifebemtinib (tosylate) is applicable in cancer research, including studies on solid tumors, breast cancer, and malignant pleural mesothelioma.
    Fórmula:C35H36F4N6O7S
    Cor e Forma:Solid
    Peso molecular:760.76

    Ref: TM-T211841