FAK
Os inibidores da quinase de adesão focal (FAK) têm como alvo a FAK, uma quinase envolvida na adesão celular, migração e angiogênese. A FAK é frequentemente superexpressa em tumores e contribui para a formação de novos vasos sanguíneos que fornecem nutrientes ao tumor. Inibir a FAK pode interromper esses processos, tornando os inibidores de FAK ferramentas valiosas na terapia do câncer e na pesquisa de angiogênese. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de FAK de alta qualidade para apoiar sua pesquisa em biologia celular, câncer e angiogênese.
Foram encontrados 74 produtos para "FAK".
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NVP-TAE 226
CAS:NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.Fórmula:C23H25ClN6O3Pureza:98.07% - 98.78%Cor e Forma:SolidPeso molecular:468.936PF-562271 besylate
CAS:PF-562271 besylate: potent, ATP-competitive FAK inhibitor, IC50 1.5 nM, 10x less effective on Pyk2, highly selective vs other kinases.Fórmula:C27H26F3N7O6S2Pureza:97.65% - 99.01%Cor e Forma:SolidPeso molecular:665.664PND-1186
CAS:PND-1186 (VS-4718) is a reversible and specific FAK inhibitor (IC50: 1.5 nM).Fórmula:C25H26F3N5O3Pureza:99.14% - 99.75%Cor e Forma:SolidPeso molecular:501.5008CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Fórmula:C30H38ClN7O3Pureza:98.86% - 99.98%Cor e Forma:White SolidPeso molecular:580.121PF-562271
CAS:PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM).Fórmula:C21H20F3N7O3SPureza:97.48% - >99.99%Cor e Forma:White SolidPeso molecular:507.489FAK activator 1
CAS:ZINC40099027 is a FAK activator that induces gastric mucosal repair in persistent aspirin-associated gastric injury.Fórmula:C23H26F3N3O3Pureza:99.13%Cor e Forma:SolidPeso molecular:449.47PF-719 free base
CAS:PF-719 is a potent, selective Pyk2 inhibitor with IC50 of 17 nM.Fórmula:C22H27F3N6OCor e Forma:SolidPeso molecular:448.48PH11
CAS:PH11, a FAK inhibitor, reactivates TRAIL apoptosis in PANC-1 cells by reducing c-FLIP and inhibiting FAK/PI3K/AKT.Fórmula:C22H22N6O5Cor e Forma:SolidPeso molecular:450.45FAK inhibitor 2
CAS:FAK inhibitor 2, antitumor and anti-angiogenesis activitiesis ,is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM .Fórmula:C29H33F3N8O2S2Cor e Forma:SolidPeso molecular:646.75MLK3-IN-1
MLK3-IN-1 (Compound 37) is a selective inhibitor of mixed-lineage kinase 3 (MLK3) with an IC50 of less than 1 nM. It also inhibits FAK with an IC50 of 15.5 μM. In both murine and human liver microsomes, MLK3-IN-1 demonstrates excellent metabolic stability.Fórmula:C20H16F6N4O2SCor e Forma:SolidPeso molecular:490.422NAMI-A
CAS:NAMI-A is a ruthenium-based compound with selective activity against tumor metastasis.NAMI-A inhibits cancer cell adhesion and migration.Fórmula:C8H15Cl4N4ORuSPureza:98%Cor e Forma:Orange SolidPeso molecular:458.18Y 11
CAS:focal adhesion kinase (FAK) inhibitorFórmula:C8H17BrN4OPureza:98%Cor e Forma:SolidPeso molecular:265.15ProMMP-9 inhibitor-3c
CAS:ProMMP-9 inhibitor-3c hinders MMP-9 homodimers, blocks proMMP-9/α4β1 integrin/CD44 binding, and detaches EGFR.Fórmula:C18H20FN3O2SCor e Forma:SolidPeso molecular:361.43FLT3-IN-17
CAS:FLT3-IN-17: FAK inhibitor, IC50 of 12 nM; blocks CYPs, FLT3 mutants; IC50 <0.5 nM for D835Y in cancer studies.Fórmula:C23H24N6O2S2Cor e Forma:SolidPeso molecular:480.61TG53
CAS:TG53 is a tissue transglutaminase (TG2) and fibronectin (FN) protein-protein interaction inhibitor.Fórmula:C21H22ClN5O2Pureza:98%Cor e Forma:SolidPeso molecular:411.885Adhesamine
CAS:Adhesamine, a dumbbell molecule, enhances cell adhesion, growth, neuron differentiation, and survival via MAPK/FAK.Fórmula:C24H32Cl4N8O2S2Cor e Forma:SolidPeso molecular:670.51FAK inhibitor 5
CAS:FAK inhibitor 5 is a novel allosteric FAK inhibitor, with IC50 values in the low micromolar range.Fórmula:C20H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:367.46MY-1576
CAS:MY-1576 is a FAK inhibitor with an IC50 of 8 nM. It activates the Hippo pathway, thereby inhibiting YAP/TAZ regulation. Additionally, MY-1576 effectively suppresses tumor growth in the KYSE30 xenograft mouse model, demonstrates good safety, and efficiently downregulates FAK autophosphorylation and YAP/TAZ levels in vivo.Fórmula:C25H29ClN8O2Cor e Forma:SolidPeso molecular:509.01FAK-IN-8
CAS:FAK-IN-8 (compound 5h), a FAK inhibitor with an IC50 of 5.32 μM, exhibits potent anti-proliferative activity, making it suitable for use in cancer research [1].Fórmula:C15H9Cl2N3O2SCor e Forma:SolidPeso molecular:366.22Defactinib hydrochloride
CAS:Defactinib hydrochloride (PF 04554878 hydrochloride) is a novel inhibitor of FAK.Fórmula:C20H22ClF3N8O3SPureza:98.06% - 98.78%Cor e Forma:SolidPeso molecular:546.954
