PERK
Os inibidores de PERK (Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase) têm como alvo a via PERK, que está envolvida na resposta celular ao estresse do retículo endoplasmático (ER) e na regulação da apoptose. PERK desempenha um papel crítico na resposta a proteínas mal enoveladas (UPR), interrompendo a tradução de proteínas e promovendo a sobrevivência celular sob condições de estresse. No entanto, a ativação prolongada de PERK pode levar à apoptose. A inibição de PERK pode modular essas respostas ao estresse, tornando esses inibidores valiosos na pesquisa de doenças neurodegenerativas, câncer e distúrbios metabólicos. Na CymitQuimica, oferecemos uma gama de inibidores de PERK de alta qualidade para apoiar sua pesquisa em apoptose, estresse do RE e homeostase celular.
Foram encontrados 26 produtos de "PERK"
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Daraxonrasib
CAS:Daraxonrasib is a potent RAS(ON)MULTI inhibitor with broad-spectrum inhibitory activity against RAS-GTP.Cost-effective and quality-assured.Fórmula:C44H58N8O5SPureza:98.24% - 99.96%Cor e Forma:SolidPeso molecular:811.05PERK-IN-6
CAS:PERK-IN-6 is a novel and highly potent PERK inhibitor (IC50:2.5 nM).Fórmula:C23H22N6OPureza:99.62% - 99.92%Cor e Forma:SolidPeso molecular:398.46PERK-IN-4
CAS:PERK-IN-4 is a potent and selective PERK inhibitor with an IC50 value of 0.3 nM.PERK-IN-4 can be used in the study of cancer and neurological disorders.Fórmula:C24H19F4N5OPureza:99.44% - 99.49%Cor e Forma:SolidPeso molecular:469.43Claturafenib
CAS:Claturafenib is a brain-permeable, selective, all-mutant BRAF inhibitor.PF-07799933 has shown antitumor activity, used in combination with MEK inhibitors.Fórmula:C18H15Cl2F2N5O3SPureza:98.68% - 99.85%Cor e Forma:SolidPeso molecular:490.31EIF2α activator 2
CAS:EIF2α activator 2 is an activator of eIF2α phosphorylation, anti-proliferative in SRB, K562, and PBMC cells, suitable for cancer research.Fórmula:C21H20F6N2O2Pureza:98.86%Cor e Forma:SolidPeso molecular:446.39Ref: TM-T62637
1mg62,00€5mg130,00€10mg203,00€25mg380,00€50mg556,00€100mg799,00€200mg1.094,00€1mL*10mM (DMSO)144,00€2BAct
CAS:2BAct is a novel eif2b activator, preventing neurological defects caused by a chronic integrated stress responseFórmula:C19H16ClF3N4O3Pureza:97.97% - 99.04%Cor e Forma:SolidPeso molecular:440.8Takeda-6d
CAS:Takeda-6d is a novel, potent DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitor with IC50 of 7.0 nM and 2.2 nM, respectively.Fórmula:C27H19ClFN5O3SPureza:98.27%Cor e Forma:SolidPeso molecular:547.99Ref: TM-T22436
1mg97,00€2mg135,00€5mg188,00€10mg283,00€25mg462,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)255,00€ONO-8130
CAS:ONO-8130 is an orally available antagonist of EP1 receptor.Fórmula:C25H28N2O5S2Pureza:97.82%Cor e Forma:SolidPeso molecular:500.63GSK621
CAS:GSK621 is a specific and potent AMPK activator.Fórmula:C26H20ClN3O5Pureza:97.02% - 97.05%Cor e Forma:SolidPeso molecular:489.91Ref: TM-T6854
1mg52,00€2mgA consultar5mg106,00€10mg180,00€25mg311,00€50mg502,00€100mg743,00€200mg1.026,00€IACS-13909
CAS:IACS-13909 (BBP-398), a specific and potent allosteric inhibitor of SHP2, that suppresses signaling through the MAPK pathway.Fórmula:C17H18Cl2N6Pureza:98.8%Cor e Forma:SolidPeso molecular:377.27GSK2606414
CAS:GSK2606414 is a cell-permeable and orally active protein kinase R-like endoplasmic reticulum kinase（PERK）inhibitor.Cost-effective and quality-assured.Fórmula:C24H20F3N5OPureza:98% - >99.99%Cor e Forma:SolidPeso molecular:451.44Bufotalin
CAS:<p>1. Bufotalin (Bufotaline)e is a kind of poisonous secretions of toads.</p>Fórmula:C26H36O6Pureza:99.45% - 99.91%Cor e Forma:White To Off-White SolidPeso molecular:444.56SHP099
CAS:SHP099 (SHP099 free base) free base is an effective, selective, orally bioavailable, and efficacious SHP2 inhibitor (IC50 =0.07 μM and p-ERK modulation in cellsFórmula:C16H19Cl2N5Pureza:98.73% - 99.4%Cor e Forma:SolidPeso molecular:352.26Ref: TM-T3564
1mg37,00€2mg52,00€5mg79,00€10mg99,00€25mg168,00€50mg225,00€100mg409,00€1mL*10mM (DMSO)60,00€ISRIB (trans-isomer)
CAS:ISRIB (trans-isomer) is a potent inhibitor of PERK that rescues protein translation and prevents SG formation in the presence of P-eIF2α. Cost effective and quality assured.Fórmula:C22H24Cl2N2O4Pureza:97.86% - 99.27%Cor e Forma:SolidPeso molecular:451.34GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Fórmula:C23H21FN6OPureza:98.59% - >99.99%Cor e Forma:SolidPeso molecular:416.45Ref: TM-T2654
2mg35,00€5mg50,00€10mg81,00€25mg142,00€50mg259,00€100mg467,00€200mg632,00€1mL*10mM (DMSO)56,00€SHP389
CAS:SHP389 is a highly effective allosteric inhibitor of SHP2, inhibiting SHP2 and p-ERK, used in cancer research.Fórmula:C23H29ClN8O2Pureza:98.24%Cor e Forma:SolidPeso molecular:484.98DNL343
CAS:DNL343 is an eIF2B activator that inhibits stress granule (SG) assembly induced by the C9ORF72 dipeptide repeat.Fórmula:C20H19ClF3N3O4Pureza:99.96%Cor e Forma:SolidPeso molecular:457.83eIF4A3-IN-1
CAS:<p>eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A3 (eIF4A3). eIF4A3-IN-1 inhibits cytosolic nonsense-mediated RNA decay at high concentrations.</p>Fórmula:C29H23BrClN5O2Pureza:99.49% - 99.89%Cor e Forma:SolidPeso molecular:588.88PF-07284892
CAS:PF-07284892 (ARRY-558) is an orally active allosteric SHP2 inhibitor (IC50 = 21 nM) that reduces pERK expression and may be employed in solid tumour research.Fórmula:C21H22ClN7SPureza:97.77%Cor e Forma:SolidPeso molecular:439.96GCN2-IN-6
CAS:GCN2-IN-6: Potent, oral GCN2/PERK inhibitor; IC50s - GCN2: 1.8 nM (enzymatic), 9.3 nM (cellular); PERK: 0.26 nM (enzymatic), 230 nM (cellular).Fórmula:C19H12Cl2F2N4O3SPureza:95.04% - 98%Cor e Forma:SolidPeso molecular:485.29
