Caspase
Os inibidores de caspases são compostos que bloqueiam a atividade das caspases, uma família de proteases que são executores centrais da apoptose. As caspases clivam substratos específicos dentro da célula para desencadear o processo apoptótico, levando à morte celular programada. Os inibidores de caspases são usados para estudar os mecanismos da apoptose, bem como para prevenir a morte celular indesejada em vários modelos de pesquisa. Esses inibidores também são explorados em contextos terapêuticos para proteger as células da apoptose em doenças como a neurodegeneração. Na CymitQuimica, oferecemos uma ampla gama de inibidores de caspases de alta qualidade para apoiar sua pesquisa em apoptose, morte celular e áreas relacionadas.
Foram encontrados 125 produtos de "Caspase"
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Almorexant
CAS:<p>Almorexant (ACT 078573), a strong dual orexin receptor antagonist, has Ki of 1.3 nM for OX1 and 0.17 nM for OX2.</p>Fórmula:C29H31F3N2O3Pureza:97.75% - 98.02%Cor e Forma:SolidPeso molecular:512.56Asperosaponin VI
CAS:<p>Asperosaponin VI, from Dipsacus asper rhizome, treats back pain, hematoma, and fractures.</p>Fórmula:C47H76O18Pureza:97.15% - 99.79%Cor e Forma:SolidPeso molecular:929.1Z-IETD-FMK
CAS:<p>Z-IETD-FMK (Z-IE(OMe)TD(OMe)-FMK) is a selective caspase 8 inhibitor, which has cell permeable.</p>Fórmula:C30H43FN4O11Pureza:95% - 99.81%Cor e Forma:SolidPeso molecular:654.68Ginsenoside Rh2
CAS:<p>Ginsenoside Rh2 (20(S)-Ginsenoside Rh2), an extract of red Panax ginseng, is a potent anti-inflammatory and anticancer drug.</p>Fórmula:C36H62O8Pureza:99.20% - 99.76%Cor e Forma:White PowderPeso molecular:622.872-HBA
CAS:<p>2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway.</p>Fórmula:C17H14O3Pureza:99.76%Cor e Forma:SolidPeso molecular:266.29Ac-DEVD-AMC
CAS:<p>Ac-DEVD-AMC (AC-ASP-MET-GLN-ASP-7-AMINO-4-METHYLCOUMARIN) is the substrate of Caspase-3 .</p>Fórmula:C30H37N5O13Pureza:98.20%Cor e Forma:White PowderPeso molecular:675.64KEA1-97
CAS:<p>Kea1-97 is a selective disruptor of interaction between thioredoxin and caspase-3 (IC50 = 10 μ M).</p>Fórmula:C15H9Cl2FN4Pureza:97.07%Cor e Forma:SolidPeso molecular:335.16Paris saponin VII
CAS:<p>Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.</p>Fórmula:C51H82O21Pureza:99.51% - 99.63%Cor e Forma:SolidPeso molecular:1031.18Z-VAD(OMe)-FMK
CAS:<p>View and buy Z-VAD(OMe)-FMK from TargetMol.Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor.Cited in 10 publications.</p>Fórmula:C22H30FN3O7Pureza:95.92% - 99.71%Cor e Forma:SolidPeso molecular:467.49Ac-DEVD-CHO acetate
<p>Caspase-3 Inhibitor I (N-acetyl-asp-glu-val-asp-al) is a specific inhibitor of Caspase-3.</p>Fórmula:C22H34N4O13Pureza:98.54%Cor e Forma:SolidPeso molecular:562.52PHYTOSPHINGOSINE
CAS:<p>Phytosphingosine: anticancer phospholipid; triggers apoptosis in cancer cells via caspase 8 activation and Bax translocation.</p>Fórmula:C18H39NO3Pureza:99.81%Cor e Forma:SolidPeso molecular:317.51TC11
CAS:<p>TC11 (1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis</p>Fórmula:C20H22N2O2Pureza:97.86%Cor e Forma:SolidPeso molecular:322.4Belnacasan
CAS:<p>Belnacasan (VX-765) is an orally active IL-converting enzyme/caspase-1 inhibitor.</p>Fórmula:C24H33ClN4O6Pureza:96.53% - 99.5%Cor e Forma:SolidPeso molecular:508.99Sesamolin
CAS:<p>Sesamolin and sesamin guard nerves, reduce microglia damage by blocking p38 MAPK and caspase-3, and curb nitric oxide in stimulated cells.</p>Fórmula:C20H18O7Pureza:98.77% - 99.04%Cor e Forma:SolidPeso molecular:370.35Wedelolactone
CAS:<p>Wedelolactone (IKK Inhibitor II) inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.</p>Fórmula:C16H10O7Pureza:98.07% - 99.87%Cor e Forma:SolidPeso molecular:314.25PI-1840
CAS:<p>PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.</p>Fórmula:C22H26N4O3Pureza:98.82%Cor e Forma:SolidPeso molecular:394.47Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Cor e Forma:SolidPeso molecular:178.14Ac-DEVD-pNA
CAS:<p>Ac-DEVD-pNA is the preferred peptidic substrate for caspase-3.</p>Fórmula:C26H34N6O13Pureza:>99.99%Cor e Forma:WhitePeso molecular:638.58Z-YVAD-FMK
CAS:<p>AA-Z-YVAD-FMK is a Irreversible caspase-1 inhibitor,with anti-inflammatory and anti-tumor activities.</p>Fórmula:C31H39FN4O9Pureza:98.00%Cor e Forma:SolidPeso molecular:630.66Emricasan
CAS:<p>Emricasan (IDN-6556) is a pan-caspase inhibitor with irreversible properties.</p>Fórmula:C26H27F4N3O7Pureza:98.13% - 99%Cor e Forma:SolidPeso molecular:569.5Z-FA-FMK
CAS:<p>Z-FA-FMK can irreversibly inhibit cysteine protease and also inhibit effector caspases.</p>Fórmula:C21H23FN2O4Pureza:98.84% - 99.68%Cor e Forma:SolidPeso molecular:386.42Dihydrocapsaicin
CAS:<p>Dihydrocapsaicin, similar to capsaicin, is an irritant found in Capsicum, used in "pure" capsaicin products at about 10%, activates VR1, and is an antioxidant.</p>Fórmula:C18H29NO3Pureza:99.61% - ≥95%Cor e Forma:White CrystalPeso molecular:307.43Aristolactam I
CAS:<p>Aristolactam I (Aristololactum) has cytotoxic potency, mediated through the induction of apoptosis in a caspase 3-dependent pathway.</p>Fórmula:C17H11NO4Pureza:98.98% - 99.63%Cor e Forma:SolidPeso molecular:293.27Ossirene
CAS:<p>Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.</p>Fórmula:C2H4Cl3O2Te·H4NPureza:≥98%Cor e Forma:SolidPeso molecular:312.05Tauroursodeoxycholate
CAS:<p>Tauroursodeoxycholate (UR 906), a hydrophilic bile acid, low in humans, may treat PBC, insulin resistance, and ALS.</p>Fórmula:C26H45NO6SPureza:98.77% - 99.93%Cor e Forma:White SolidPeso molecular:499.7Senkyunolide I
CAS:<p>1. Senkyunolide I has neuroprotective effect, associated with its anti-oxidation and anti-apoptosis properties.</p>Fórmula:C12H16O4Pureza:99.73% - 99.88%Cor e Forma:SolidPeso molecular:224.25Diclofenac Potassium
CAS:<p>Diclofenac Potassium (CGP-45840B) is a nonsteroidal anti-inflammatory drug taken to reduce inflammation and as an analgesic reducing pain in certain conditions.</p>Fórmula:C14H10Cl2KNO2Pureza:99.51%Cor e Forma:White To Yellowish Crystalline PowderPeso molecular:334.24CASP3 Activator 1541
CAS:<p>CASP3 Activator 1541 is an activator of the proenzyme forms of caspase-3, and induces cell death.</p>Fórmula:C24H17N3O4Pureza:98.84%Cor e Forma:SolidPeso molecular:411.41L67
CAS:<p>L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM).</p>Fórmula:C16H14Br2N4O4Pureza:98.34% - 99.56%Cor e Forma:SolidPeso molecular:486.11Phenoxodiol
CAS:<p>Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)</p>Fórmula:C15H12O3Pureza:98.07%Cor e Forma:SolidPeso molecular:240.25AVN-944
CAS:<p>AVN-944 (VX-944)(VX-944) is a selective, noncompetitive inhibitor of human IMPDH with Ki of 6-10 nM for IMPDH1/IMPDH2.</p>Fórmula:C25H27N5O5Pureza:99.07% - ≥95%Cor e Forma:SolidPeso molecular:477.51Taurodeoxycholic acid sodium hydrate
CAS:<p>Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.</p>Fórmula:C26H46NNaO7SPureza:99.95%Cor e Forma:SolidPeso molecular:539.705,7-Dihydroxychromone
CAS:<p>1.</p>Fórmula:C9H6O4Pureza:99.76% - ≥95%Cor e Forma:SolidPeso molecular:178.14Boc-Asp(OMe)-fluoromethyl ketone
CAS:<p>Boc-Asp(OMe)-FMK is a broad-spectrum caspase inhibitor that blocks Fas-mediated processes without affecting IL-8 chemotaxis.</p>Fórmula:C11H18FNO5Pureza:≥98%Cor e Forma:SolidPeso molecular:263.26Tauroursodeoxycholate sodium
CAS:<p>Tauroursodeoxycholate sodium (TUDC) is an endoplasmic reticulum (ER) stress inhibitor, used for the treatment of gallstones and liver cirrhosis.</p>Fórmula:C26H44NNaO6SPureza:97.90%Cor e Forma:SolidPeso molecular:521.69Z-VAD-FMK
CAS:<p>Z-VAD-FMK (Caspase Inhibitor VI) is a broad-spectrum inhibitor of caspases.Z-VAD-FMK binds to activated caspases and inhibits apoptosis.Z-VAD-FMK does not</p>Fórmula:C21H28FN3O7Pureza:98.24% - 99.79%Cor e Forma:SolidPeso molecular:453.46(E/Z)-Necrosulfonamide
CAS:<p>(E/Z)-Necrosulfonamide is a novel inhibitor of MLKL.</p>Fórmula:C18H15N5O6S2Pureza:97.62% - 98%Cor e Forma:SolidPeso molecular:461.47Lobaplatin
CAS:<p>Lobaplatin (D-19466) (D-19466) is a diastereometric mixture of platinum(II) complexe.</p>Fórmula:C9H18N2O3PtPureza:98.00%Cor e Forma:SolidPeso molecular:397.33Z-DEVD-FMK
CAS:<p>Z-DEVD-FMK (Caspase-3 Inhibitor) is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7,</p>Fórmula:C30H41FN4O12Pureza:96.19% - 99.69%Cor e Forma:SolidPeso molecular:668.66Arnicolide D
CAS:<p>Arnicolide D is a sesquiterpene lactone.</p>Fórmula:C19H24O5Pureza:96.66%Cor e Forma:SolidPeso molecular:332.39Dehydrocorydaline nitrate
CAS:<p>DHC curbs antibody and cell-mediated allergies, inhibits mitochondrial potential in macrophages, and has antinociceptive, anti-inflammatory effects.</p>Fórmula:C22H24N2O7Pureza:99.79% - 99.92%Cor e Forma:SolidPeso molecular:428.44Dehydrotrametenolic acid
CAS:<p>Dehydrotrametenolic acid (Dehydroeburicoic acid) induces necrotic cell death that involves Ca(2+) overload, mitochondrial dysfunction, and calpain activation in</p>Fórmula:C31H48O3Pureza:98%Cor e Forma:SolidPeso molecular:468.71Limonin glucoside
CAS:<p>Limonin glucoside: a citrus compound, blocks HIV/HTLV-1, triggers cancer cell death, kills Aedes larvae.</p>Fórmula:C32H42O14Cor e Forma:SolidPeso molecular:650.674Caspase-3-IN-1
CAS:<p>Caspase-3-IN-1 is a potent inhibitor of Caspase-3 (IC50: 14.5 nM).</p>Fórmula:C26H25N3O6SCor e Forma:SolidPeso molecular:507.56Tigilanol tiglate
CAS:<p>Tigilanol tiglate (EBC-46) is a PKC/C1 domain activator. Tigilanol tiglate induces immunogenic cell death and tumour regression.</p>Fórmula:C30H42O10Pureza:98%Cor e Forma:SolidPeso molecular:562.65Anisperimus
CAS:<p>Anisperimus (LF 15-0195) is an immunosuppressant that prevents CNS autoimmunity by promoting the development of regulatory CD4 T cells expressing Foxp3.</p>Fórmula:C18H39N7O3Pureza:98.10%Cor e Forma:SolidPeso molecular:401.55AD-2646
CAS:<p>AD-2646 has antidepressant activity and inhibits 2-deoxy-D-glucose (2-DG)-induced gastric acid secretion.</p>Fórmula:C23H40N2O4Cor e Forma:SolidPeso molecular:408.57ZYZ-488
CAS:<p>ZYZ-488 is an Apoptosis protease activating factor-1 (Apaf-1) inhibitor, which suppresses the activation of procaspase-9 and procaspase-3.</p>Fórmula:C20H29N3O11Pureza:99.04%Cor e Forma:SolidPeso molecular:487.46Caspase-9 Inhibitor III
CAS:<p>Caspase-9 Inhibitor III (Ac-LEHD-cmk) blocks caspase-9, protects against ischemic heart damage.</p>Fórmula:C24H35ClN6O9Cor e Forma:SolidPeso molecular:587.02
