CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Fórmula:C32H44O8Pureza:98.88% - 99.87%Cor e Forma:SolidPeso molecular:556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€1mL*10mM (DMSO)133,00€Abemaciclib methanesulfonate
CAS:Abemaciclib methanesulfonate (LY2835219) is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM).
Fórmula:C27H32F2N8·CH4O3SPureza:98.69% - 99.44%Cor e Forma:SolidPeso molecular:602.7PF-562271 hydrochloride
CAS:PF-562271 hydrochloride (PF-562271 HCl) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK.Fórmula:C21H20F3N7O3SHClPureza:97.08%Cor e Forma:SolidPeso molecular:543.95Dalpiciclib hydrochloride
Dalpiciclib (SHR-6390) HCl is an oral CDK4/6 inhibitor with IC50s of 12.4/9.9 nM, an antitumor for breast and esophageal cancers.Fórmula:C25H31ClN6O2Cor e Forma:SolidPeso molecular:483.01Senexin A
CAS:Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively.Fórmula:C17H14N4Pureza:99.74%Cor e Forma:SolidPeso molecular:274.32Ref: TM-T5673
1mg34,00€5mg73,00€10mg94,00€25mg177,00€50mg323,00€100mg460,00€200mg622,00€1mL*10mM (DMSO)71,00€SEL120-34A HCl
CAS:SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectivelyFórmula:C15H19Br2ClN4Pureza:98.13% - 98.47%Cor e Forma:SolidPeso molecular:450.6SNS-032
CAS:SNS-032 (BMS-387032) is a selective inhibitor of CDK2 and is 10- and 20-fold selective over CDK1/CDK4. SNS-032 is sensitive to CDK7/9, and no effect on CDK6.Fórmula:C17H24N4O2S2Pureza:98.27% - 99.91%Cor e Forma:SolidPeso molecular:380.53Ref: TM-T6049
5mg50,00€10mg66,00€25mg96,00€50mg131,00€100mg213,00€200mg316,00€500mg532,00€1mL*10mM (DMSO)52,00€PHA-767491 hydrochloride
CAS:PHA-767491 (CAY-10572) is a potent Cdc7/CDK9 inhibitor (IC50: 10/34 nM), selective against GSK3-β, CDK1/2, CDK5, MK2, CHK2, PLK1.Fórmula:C12H12ClN3OPureza:99.56% - 99.92%Cor e Forma:SolidPeso molecular:249.69AZD-5597
CAS:AZD-5597 ((S)-(4-((5-Fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimidin-2-yl)amino)phenyl)(3-(methylamino)pyrrolidin-1-yl)methanone) is a potent
Fórmula:C23H28FN7OPureza:98.01%Cor e Forma:SolidPeso molecular:437.51AS2863619
CAS:AS2863619 is an oral inhibitor of cyclin-dependent kinase(CDK8) and CDK19. Inhibition of CDK8/19 enhances STAT5 activation.Cost-effective and quality-assured.Fórmula:C16H14Cl2N8OPureza:>99.99%Cor e Forma:SolidPeso molecular:405.24Ref: TM-T8378
1mg124,00€2mg170,00€5mg260,00€10mg409,00€25mg677,00€50mg954,00€100mg1.288,00€1mL*10mM (DMSO)286,00€PHA-767491
CAS:PHA-767491 (CAY10572) is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively.Fórmula:C12H11N3OPureza:99.49% - >99.99%Cor e Forma:SolidPeso molecular:213.24Ref: TM-T6206
2mg34,00€5mg49,00€10mg64,00€25mg92,00€50mg138,00€100mg197,00€200mg295,00€1mL*10mM (DMSO)50,00€6-(Dimethylamino)purine
CAS:6-(Dimethylamino)purine (N,N-Dimethyladenine) is a serine threonine protein kinase and CDK inhibitorFórmula:C7H9N5Pureza:99.01% - 99.77%Cor e Forma:SolidPeso molecular:163.18NVP-LCQ195
CAS:NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).Fórmula:C17H19Cl2N5O4SPureza:99.56% - 99.85%Cor e Forma:SolidPeso molecular:460.33Ref: TM-TQ0068
1mg46,00€5mg92,00€10mg138,00€25mg255,00€50mg374,00€100mg533,00€200mg705,00€1mL*10mM (DMSO)94,00€ON-013100
CAS:ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression.Fórmula:C19H22O7SPureza:98.27%Cor e Forma:SolidPeso molecular:394.44Ref: TM-T16391
1mg50,00€5mg74,00€10mg105,00€25mg182,00€50mg283,00€100mg425,00€200mg602,00€1mL*10mM (DMSO)64,00€LDC000067
CAS:LDC000067 (LDC067) is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.Fórmula:C18H18N4O3SPureza:98.08% - 99.07%Cor e Forma:SolidPeso molecular:370.43AT7519 TFA
CAS:AT7519 inhibits CDK1-6 kinases; IC50 ranges 0.018-0.66 μM.Fórmula:C18H18Cl2F3N5O4Cor e Forma:SolidPeso molecular:496.27Senexin B
CAS:Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).Fórmula:C27H26N6OPureza:99.67%Cor e Forma:SolidPeso molecular:450.53Ref: TM-T8430
1mg92,00€5mg178,00€10mg260,00€25mg401,00€50mg532,00€100mg708,00€200mg964,00€1mL*10mM (DMSO)203,00€LY3143921
CAS:LY3143921 ((S)-Example 2) is an orally active inhibitor of CDC7 kinase with broad in vitro anticancer activity [1].Fórmula:C16H12FN5OCor e Forma:SolidPeso molecular:309.3THAL-SNS-032
CAS:THAL-SNS-032 is a selective CDK9 degrader PROTAC.Fórmula:C40H52N8O10S2Pureza:99.68%Cor e Forma:SolidPeso molecular:869.02Ref: TM-T17069
1mg116,00€5mg274,00€10mg410,00€25mg657,00€50mg934,00€100mg1.264,00€1mL*10mM (DMSO)411,00€Palbociclib dihydrochloride
Palbociclib, oral CDK4/6 inhibitor (IC50: 11/16 nM), targets HR+/HER2- breast cancer and hepatocellular carcinoma.Fórmula:C24H31Cl2N7O2Cor e Forma:SolidPeso molecular:520.45
