CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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Abemaciclib
CAS:Abemaciclib (LY2835219) is a dual inhibitor of CDK4/6 (IC50=2/10 nM) with selectivity and specificity.Fórmula:C27H32F2N8Pureza:99.43% - 99.87%Cor e Forma:SolidPeso molecular:506.59NSC23005 Sodium
CAS:NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models.Fórmula:C13H16NNaO4SPureza:99.64%Cor e Forma:SolidPeso molecular:305.32BSJ-4-116
CAS:BSJ-4-116: potent, selective CDK12 PROTAC, IC50 = 6 nM; downregulates DDR genes, induces premature transcription termination.Fórmula:C40H49ClN8O8SPureza:99.09%Cor e Forma:SolidPeso molecular:837.38ALSTERPAULLONE
CAS:Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing EffecFórmula:C16H11N3O3Pureza:99.8%Cor e Forma:SolidPeso molecular:293.28Ref: TM-T7426
1mg55,00€5mg110,00€10mg173,00€25mg296,00€50mg424,00€100mg587,00€200mg792,00€1mL*10mM (DMSO)105,00€BS-181 hydrochloride
CAS:BS-181 hydrochloride (BS-181 HCl) is a highly selective CDK7 inhibitor with IC50 of 21 nM.Fórmula:C22H32N6·HClPureza:99.21%Cor e Forma:SolidPeso molecular:416.99Ref: TM-T6162
1mg37,00€2mg52,00€5mg79,00€10mg116,00€25mg250,00€50mg416,00€100mg645,00€200mgA consultar1mL*10mM (DMSO)87,00€JNJ-7706621
CAS:JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2.Fórmula:C15H12F2N6O3SPureza:99.1% - 99.85%Cor e Forma:SolidPeso molecular:394.36Ref: TM-T6126
1mg48,00€5mg100,00€10mg155,00€25mg268,00€50mg432,00€100mg595,00€200mg833,00€1mL*10mM (DMSO)94,00€MC180295
CAS:MC180295 ((rel)-MC180295) is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs.Fórmula:C17H18N4O3SPureza:99.84%Cor e Forma:SolidPeso molecular:358.41Ref: TM-T5533
1mg52,00€5mg124,00€10mg177,00€25mg301,00€50mg424,00€100mg605,00€200mg797,00€1mL*10mM (DMSO)136,00€ML167
CAS:ML167 (CID44968231) is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor.
Fórmula:C19H17N3O3Pureza:99.82% - >99.99%Cor e Forma:SolidPeso molecular:335.36R547
CAS:R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.Fórmula:C18H21F2N5O4SPureza:90% - 99.64%Cor e Forma:SolidPeso molecular:441.45Ref: TM-T6312
1mg48,00€5mg96,00€10mg140,00€25mg254,00€50mg487,00€100mg700,00€200mg973,00€1mL*10mM (DMSO)114,00€Bohemine
CAS:Bohemine is a cyclin-dependent kinase inhibitor.Fórmula:C18H24N6OPureza:99.09% - 99.53%Cor e Forma:SolidPeso molecular:340.42THZ531
CAS:THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM).Fórmula:C30H32ClN7O2Pureza:97.17% - 99.86%Cor e Forma:SolidPeso molecular:558.07Ref: TM-T4293
1mg63,00€2mg90,00€5mg111,00€10mg153,00€25mg329,00€50mg472,00€100mg687,00€500mg1.415,00€1mL*10mM (DMSO)137,00€PHA-793887
CAS:PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.Fórmula:C19H31N5O2Pureza:98.02% - >99.99%Cor e Forma:SolidPeso molecular:361.48Ref: TM-T2113
2mg34,00€5mg49,00€10mg75,00€25mg114,00€50mg185,00€100mg298,00€200mg444,00€1mL*10mM (DMSO)50,00€AUZ 454
CAS:AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd of 50/18.6/15.4/9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely.Fórmula:C24H26F3N7O2Pureza:99.59%Cor e Forma:SolidPeso molecular:501.5AMG 925
CAS:AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively.Fórmula:C26H29N7O2Pureza:99.75%Cor e Forma:SolidPeso molecular:471.55CID44216842
CAS:CID44216842 is a potent Cdc42-selective inhibitor with EC50: 1.0μM (WT), 1.2μM (Q61L) in GTP assay; 0.3μM (WT), 0.5μM (Q61L) in GDP assay. Use as a probe.Fórmula:C22H20BrN3O3SPureza:99.66%Cor e Forma:SolidPeso molecular:486.38Ref: TM-T8930
2mg34,00€5mg50,00€10mg85,00€25mg159,00€50mg244,00€100mg359,00€200mg512,00€1mL*10mM (DMSO)55,00€THZ2
CAS:THZ2 (CDK7-IN-1), an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC).Fórmula:C31H28ClN7O2Pureza:98.28%Cor e Forma:SolidPeso molecular:566.05CVT-313
CAS:CVT-313 (NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor.Fórmula:C20H28N6O3Pureza:97.46% - 97.97%Cor e Forma:SolidPeso molecular:400.47GSK 3 Inhibitor IX
CAS:GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.Fórmula:C16H10BrN3O2Pureza:98% - 99.72%Cor e Forma:SolidPeso molecular:356.17Ref: TM-T1917
1mg42,00€2mg52,00€5mg78,00€10mg96,00€25mg216,00€50mg389,00€100mg577,00€500mg1.234,00€1mL*10mM (DMSO)86,00€Purvalanol B
CAS:Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)Fórmula:C20H25ClN6O3Pureza:98.95%Cor e Forma:SolidPeso molecular:432.9Ref: TM-T7167
1mg34,00€2mg46,00€5mg67,00€10mg90,00€25mg130,00€50mg203,00€100mg305,00€200mg447,00€1mL*10mM (DMSO)75,00€Palbociclib monohydrochloride
CAS:Palbociclib monohydrochloride (PD 0332991 hydrochloride) is a selective inhibitor of CDK4/6, with no inhibition against a panel of 36 additional protein kinases
Fórmula:C24H29N7O2·HClPureza:99.73% - >99.99%Cor e Forma:SolidPeso molecular:483.99
