CDK
Os inibidores das quinases dependentes de ciclinas (CDK) são compostos que bloqueiam a atividade das CDKs, um grupo de quinases de proteínas que regulam o ciclo celular, a transcrição e outros processos celulares. As CDKs são ativadas pela ligação às ciclinas, e sua atividade é crucial para a progressão das células através das diferentes fases do ciclo celular. Inibir as CDKs pode interromper a divisão celular, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas onde as CDKs frequentemente estão desreguladas. Os inibidores de CDK são amplamente utilizados na pesquisa do câncer e têm potencial terapêutico no tratamento de vários tipos de câncer. Na CymitQuimica, oferecemos uma seleção abrangente de inibidores de CDK de alta qualidade para apoiar sua pesquisa em controle do ciclo celular, câncer e desenvolvimento terapêutico.
Foram encontrados 542 produtos de "CDK"
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Toyocamycin
CAS:Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (Fórmula:C12H13N5O4Pureza:98.1% - 99.44%Cor e Forma:SolidPeso molecular:291.26Ref: TM-T17143
5mg47,00€10mg65,00€25mg113,00€50mg202,00€100mg354,00€500mg825,00€1mL*10mM (DMSO)50,00€Wogonin
CAS:Wogonin (Vogonin) is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.Fórmula:C16H12O5Pureza:98% - 99.8%Cor e Forma:Yellow CrystalPeso molecular:284.26Ref: TM-T2933
5mg34,00€10mg42,00€25mg59,00€50mg92,00€100mg131,00€200mg178,00€500mgA consultar1mL*10mM (DMSO)52,00€Palbociclib Isethionate
CAS:Palbociclib Isethionate (PD 0332991 isethionate) 是一种高选择性的CDK4/6抑制剂，IC50为11 nM 和16 nM。它对一组 36 种额外的蛋白激酶没有抑制作用。
Fórmula:C24H29N7O2·C2H6O4SPureza:99.01% - 99.27%Cor e Forma:SolidPeso molecular:573.66SU9516
CAS:SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively.Fórmula:C13H11N3O2Pureza:99.34% - 99.96%Cor e Forma:SolidPeso molecular:241.25Ref: TM-T6167
1mg35,00€2mg50,00€5mg73,00€10mg103,00€25mg208,00€50mg376,00€100mg560,00€500mg1.216,00€1mL*10mM (DMSO)74,00€BI-1347
CAS:BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model.Fórmula:C22H20N4OPureza:96.7% - 99.63%Cor e Forma:SolidPeso molecular:356.42Ref: TM-T5405
1mg40,00€5mg88,00€10mg126,00€25mg240,00€50mg439,00€100mg647,00€500mg1.359,00€1mL*10mM (DMSO)87,00€SRI-29329
CAS:SRI-29329 is a potent, specific inhibitor of CDC-like kinase (with IC50 of 78 nM, 16 nM and 86 nM for CLK1, CLK2 and CLK4, respectively).Fórmula:C20H26ClN7Pureza:99.18%Cor e Forma:SolidPeso molecular:399.92NSC23005
CAS:NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM).Fórmula:C13H17NO4SPureza:>99.99%Cor e Forma:SolidPeso molecular:283.34AT7519
CAS:AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.Fórmula:C16H17Cl2N5O2Pureza:98.88% - 99.65%Cor e Forma:SolidPeso molecular:382.24(E/Z)-TG003
CAS:(E/Z)-TG003 is a potent and ATP-competitive Cdc2-like kinase (Clk) inhibitor.Fórmula:C13H15NO2SPureza:98% - 99.04%Cor e Forma:SolidPeso molecular:249.33Ref: TM-T1901
2mg42,00€5mg52,00€10mg92,00€25mg164,00€50mg271,00€100mg399,00€200mg567,00€1mL*10mM (DMSO)52,00€TP-353
CAS:TP-353 (EOS-61973) is a CDK7 inhibitor.Fórmula:C35H30FNO3Pureza:99.12%Cor e Forma:SolidPeso molecular:531.62Ref: TM-T22440
1mg43,00€5mg80,00€10mg129,00€25mg225,00€50mg314,00€100mg432,00€200mg597,00€1mL*10mM (DMSO)105,00€Trilaciclib
CAS:Trilaciclib is a short-acting, orally effective CDK4/6 inhibitor with IC₅₀ values of 1 nM and 4 nM respectively. enhances antitumour immunity.Fórmula:C24H30N8OPureza:99.624%Cor e Forma:SolidPeso molecular:446.55LSN2839567
CAS:LSN2839567 (Abemaciclib metabolite M2) is a CDK4 and CDK6 inhibitor with anticancer activity, inhibits CDK9, and can be used in breast cancer research.Fórmula:C25H28F2N8Pureza:99.14%Cor e Forma:SolidPeso molecular:478.54CDK12-IN-5
CAS:CDK12-IN-5 is a potent CDK12 inhibitor with potential anticancer and antitumor activity, and can be used orally in the study of breast and ovarian cancer.Fórmula:C18H15F5N8OPureza:99.37%Cor e Forma:SolidPeso molecular:454.36Ref: TM-T40290
1mg165,00€5mg399,00€10mg645,00€25mg1.320,00€50mg2.080,00€100mg2.822,00€1mL*10mM (DMSO)439,00€(R)-(+)-O-Demethylbuchenavianine
CAS:(R)-(+)-O-Demethylbuchenavianine is a cyclin-dependent kinase (CDK) inhibitor. It inhibits CDK1, CDK5, glycogen synthase kinase 3 (GSK3), cdc2-like kinase (CLK1), and dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) with IC50 values of 1.1 μM, 0.95 μM, >10 μM, >10 μM, and >10 μM, respectively.Fórmula:C21H21NO4Cor e Forma:SolidPeso molecular:351.40Riviciclib hydrochloride
CAS:Riviciclib hydrochloride (P276-00) is a novel CDK1, CDK4 and CDK9 inhibitor with IC50 of 79 nM, 63 nM and 20 nM, respectively. Phase 2/3.Fórmula:C21H20ClNO5·HClPureza:99.51%Cor e Forma:SolidPeso molecular:438.3XL413
CAS:XL-413 is an oral CDC7 kinase inhibitor, potentially blocking DNA replication, mitosis, and cancer cell growth.Fórmula:C14H12ClN3O2Pureza:98.40% - 99.94%Cor e Forma:SolidPeso molecular:289.72CP681301
CAS:CP681301 is a potent CDK5 inhibitor with anti-tumor effects in Drosophila and reduces Glioma stem cells' growth and renewal.Fórmula:C17H22N4OCor e Forma:SolidPeso molecular:298.38CCT068127
CAS:CCT068127 is a potent CDK2 and CDK9 inhibitor.Fórmula:C19H27N7OCor e Forma:SolidPeso molecular:369.46P18IN003
CAS:P18IN003 is a selective and effective p18(INK4C) inhibitor that inhibits the activity of p18 protein and can be used to study in vitro expansion ofFórmula:C17H16N2O3Pureza:99%Cor e Forma:SolidPeso molecular:296.32CDK9-IN-14
CAS:CDK9-IN-14: Potent CDK9 inhibitor, IC50=6.92 nM, effective on MV-4-11 cells and in vivo tumors, low toxicity, minimal side effects.Fórmula:C21H23F2N3O4Cor e Forma:SolidPeso molecular:419.42
