Microtúbulo associado
Os inibidores de proteínas associadas aos microtúbulos têm como alvo as proteínas que interagem com os microtúbulos, os componentes estruturais do citoesqueleto da célula que são essenciais para a divisão celular. Essas proteínas regulam a estabilidade e a dinâmica dos microtúbulos durante a mitose. A inibição de proteínas associadas aos microtúbulos pode interromper a função dos microtúbulos, levando à parada do ciclo celular e à apoptose, especialmente em células cancerígenas de rápida divisão. Esses inibidores são amplamente utilizados na pesquisa do câncer e no desenvolvimento de medicamentos. Na CymitQuimica, oferecemos uma ampla gama de inibidores de proteínas associadas aos microtúbulos de alta qualidade para apoiar sua pesquisa em divisão celular, dinâmica do citoesqueleto e terapia do câncer.
Foram encontrados 286 produtos para "Microtúbulo associado".
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Tubulin polymerization-IN-74
CAS:Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.Fórmula:C14H11NSCor e Forma:SolidPeso molecular:225.309Symplostatin 1
CAS:Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Fórmula:C43H70N6O6SCor e Forma:SolidPeso molecular:799.12Tubulin polymerization-IN-8
CAS:Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Fórmula:C21H24N4O4SCor e Forma:SolidPeso molecular:428.5JC168
CAS:JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.Fórmula:C26H40O7Cor e Forma:SolidPeso molecular:464.592Myoseverin B
CAS:Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.Fórmula:C27H32N6O2Cor e Forma:SolidPeso molecular:472.582Antitubulin agent 1
Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.Fórmula:C21H19N3O3Cor e Forma:SolidPeso molecular:361.39Carba1
CAS:Carba1 is a bifunctional carbazole derivative that activates nicotinamide phosphoribosyltransferase (NAMPT) and enhances the biosynthesis of NAD. It binds to the colchicine site on tubulin, potentially boosting the antitumor effects of various chemotherapeutics such as Paclitaxel. Carba1 has neuroprotective properties and regulates cellular energy metabolism. It is applicable in research on cancer and chemotherapy-induced peripheral neuropathy (CIPN).Fórmula:C18H15ClN2Peso molecular:294.78Alfalone
CAS:Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.Fórmula:C17H14O5Cor e Forma:SolidPeso molecular:298.29TTBK1/2-IN-1
CAS:TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Fórmula:C17H16N4OCor e Forma:SolidPeso molecular:292.335Tubulin polymerization-IN-34
"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."Fórmula:C31H35N3O6Cor e Forma:SolidPeso molecular:545.63AMXI-5001 hydrochloride
AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.Fórmula:C25H21ClFN5O3Cor e Forma:SolidPeso molecular:493.92TTBK1/2-IN-3
CAS:TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Fórmula:C21H22N4OCor e Forma:SolidPeso molecular:346.426Dictyostatin
CAS:Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.Fórmula:C32H52O6Cor e Forma:SolidPeso molecular:532.75AMG28
CAS:AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.Fórmula:C20H20N4OCor e Forma:SolidPeso molecular:332.399Tubulin inhibitor 19
Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.Fórmula:C21H23NO5Cor e Forma:SolidPeso molecular:369.41Epothilone E
CAS:Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFórmula:C26H39NO7SCor e Forma:SolidPeso molecular:509.66Antitumor agent-200
CAS:Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.Fórmula:C19H21FN2O3SeCor e Forma:SolidPeso molecular:423.34Tubulin inhibitor 22
Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.Fórmula:C20H17BrFNO4Cor e Forma:SolidPeso molecular:434.26Utrophin modulator 1
UM1 upregulates utrophin, has EC50 of 0.11 μM, useful in DMD research.Fórmula:C22H18N6OCor e Forma:SolidPeso molecular:382.42Tubulin polymerization-IN-35
Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.Fórmula:C31H35N3O5Cor e Forma:SolidPeso molecular:529.63
