c-Myc
Os inibidores de c-Myc têm como alvo a proteína c-Myc, um fator de transcrição que desempenha um papel crucial no crescimento celular, proliferação e apoptose. c-Myc regula a expressão de numerosos genes envolvidos no ciclo celular e é frequentemente superexpresso em vários tipos de câncer, levando a uma proliferação celular descontrolada e ao crescimento tumoral. Inibir o c-Myc pode interromper esses processos, induzindo a parada do ciclo celular e a apoptose em células cancerígenas. Os inibidores de c-Myc são ferramentas importantes na pesquisa do câncer e no desenvolvimento terapêutico. Na CymitQuimica, oferecemos uma ampla gama de inibidores de c-Myc de alta qualidade para apoiar sua pesquisa em oncologia, regulação do ciclo celular e controle transcricional.
Foram encontrados 76 produtos de "c-Myc"
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MYCi975
CAS:MYCi975 (NUCC-0200975) is an orally active inhibitor of MYC.Fórmula:C25H16Cl2F6N2O2Pureza:99.3% - 99.82%Cor e Forma:SolidPeso molecular:561.3FIDAS-5
CAS:FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. Cost-effective and quality-assured.Fórmula:C15H13ClFNPureza:98.3% - 99.17%Cor e Forma:SolidPeso molecular:261.72Ref: TM-T11285
1mg59,00€2mg85,00€5mg116,00€10mg187,00€25mg331,00€50mg512,00€100mg740,00€500mg1.415,00€Eragidomide
CAS:Eragidomide (Cereblon modulator 1) is a CRBN E3 ligase modulator, specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.Fórmula:C22H18ClF2N3O4Pureza:97.51% - 99.63%Cor e Forma:SolidPeso molecular:461.85Ref: TM-T10765
1mg38,00€5mg82,00€10mg133,00€25mg269,00€50mg442,00€100mg595,00€200mg802,00€1mL*10mM (DMSO)84,00€Saxagliptin hydrate
CAS:Saxagliptin hydrate (Onglyza hydrate) is a selective and reversible DPP4 inhibitor (IC50: 26 nM; Ki: 1.3 nM).Fórmula:C18H25N3O2·H2OPureza:99.52%Cor e Forma:SolidPeso molecular:333.43MYCi361
CAS:MYCi361 (NUCC-0196361) is an inhibitor of MYC (binding to MYC with Kd of 3.2 μM).Fórmula:C26H16ClF9N2O2Pureza:99.52%Cor e Forma:SolidPeso molecular:594.86Ceramides Mixture
CAS:Ceramides Mixture: endogenous, regulates cell cycle, growth, and telomerase activity, with hydroxy/non-hydroxy fatty acids.Fórmula:C36H71NO4Pureza:98%Cor e Forma:SolidPeso molecular:581.967MYCMI-6
CAS:MYCMI-6 inhibits MYC:MAX, reduces tumor growth, triggers apoptosis, minimal side effects.Fórmula:C20H19N7OPureza:99.23%Cor e Forma:SolidPeso molecular:373.41Ref: TM-T12134
1mg71,00€5mg152,00€10mg222,00€25mg358,00€50mg512,00€100mg707,00€200mg973,00€500mg1.431,00€KJ Pyr 9
CAS:KJ Pyr 9 is an MYC inhibitor (Kd: 6.5 nM in vitro assay).Fórmula:C22H15N3O4Pureza:99.56% - ≥98%Cor e Forma:SolidPeso molecular:385.37Ref: TM-T15665
2mg37,00€5mg54,00€10mg77,00€25mg138,00€50mg264,00€100mg482,00€200mg647,00€500mg1.009,00€1mL*10mM (DMSO)59,00€FIDAS-3
CAS:FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activitiesFórmula:C16H15F2NPureza:97.75%Cor e Forma:SolidPeso molecular:259.29Ref: TM-T11284
5mg49,00€10mg73,00€25mg127,00€50mg182,00€100mg264,00€200mg354,00€1mL*10mM (DMSO)48,00€APTO-253
CAS:APTO-253 (LOR-253) inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.Fórmula:C22H14FN5Pureza:98.73%Cor e Forma:SolidPeso molecular:367.38Ref: TM-T10352
1mg40,00€2mg52,00€5mg75,00€10mg96,00€25mg170,00€50mg255,00€100mg371,00€1mL*10mM (DMSO)84,00€PROTAC MTP3 degrade-1
PROTACMTP3 degrade-1 is a PROTAC degrader for MYC.Fórmula:C44H38N6O8Cor e Forma:SolidPeso molecular:778.27511c-Myc inhibitor 10
CAS:c-Myc inhibitor 10 enhances cell potency with improved permeability from methylated morpholine nitrogen.Fórmula:C28H38N6O3Cor e Forma:SolidPeso molecular:506.64Anticancer agent 263
Anticanceragent 263 (compound 7) is an effective anticancer agent. It binds with the G-quadruplex DNA (G4) sequence 22-mer Pu22 (a c-Myc DNA analog). As a structural modulator, Anticanceragent 263 significantly enhances the formation of protein α-helices and has the capacity to form a supramolecular network. Furthermore, Anticanceragent 263 exhibits no cytotoxicity.Fórmula:C13H20N2O6Cor e Forma:SolidPeso molecular:300.308c-Myc inhibitor 7
CAS:c-Myc inhibitor 7 degrades c-MYC, CK1α, GSPT1, IKZF1/2/3 proteins in tumors, for research on related diseases.Fórmula:C35H30N6O5Cor e Forma:SoildPeso molecular:614.65H122
H122 is a TEADPROTAC degrader effective in degrading TEAD1 with a DC50 of 3 nM, and it shows strong affinity for TEAD2, TEAD3, and TEAD4 with Ki values of 2.0, 3.6, and 1.6 nM, respectively. H122 also downregulates Myc expression and inhibits the growth of MSTO-211H and NCI-H226 cells, with IC50 values of 21.3 nM and 0.6 nM, respectively, demonstrating antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Fórmula:C45H45ClFN5O8Cor e Forma:SolidPeso molecular:838.319VTX-0811
VTX-0811 is a human IgG4 monoclonal antibody (mAb) that targets PSGL1/CD162. It modulates immune signaling pathways by enhancing TNF-α/NF-κB and chemokine-mediated signaling while reducing oxidative phosphorylation, fatty acid metabolism, and Myc signaling. VTX-0811 increases the proportion of CD8+ T cells among infiltrating T cells and exhibits antitumor activity in humanized mouse PDX models of melanoma.Cor e Forma:Odour LiquidVGN50
VGN50 is a bioactive molecule that mimics the function of K-Rta, capable of downregulating MYC-mediated gene transcription. VGN50 exhibits antitumor activity.Fórmula:C121H218N46O32Peso molecular:2827.68453RA-V
RA-V is a natural product that can be used as a reference standard.Fórmula:C160H202N24O41Cor e Forma:SolidPeso molecular:3117.5c-Myc inhibitor 13
c-Myc inhibitor13 (compound A6) is an inhibitor of c-MYC transcription. It selectively stabilizes c-MYCG4 and inhibits G4-related c-MYC transcription.Fórmula:C30H39N9OPeso molecular:541.32776Methylcarbamyl PAF C-8
Methylcarbamyl PAF C-8 is resistant to degradation by PAF-AH and has a half-life of over 100 minutes in platelet-poor plasma, exhibiting platelet aggregation activity. In NRK-49 cells overexpressing PAF receptor, it induces the expression of c-myc, c-fos, and activates mitogen-activated protein kinase (MAPK). Furthermore, Methylcarbamyl PAF C-8 can induce G1 phase cell cycle arrest. This compound shows potential for research in cardiovascular and anti-cancer applications.Cor e Forma:Odour Solid
