PKC
Os inibidores de PKC (Proteína Cinase C) têm como alvo a família de cinases serina/treonina PKC, que estão envolvidas em uma ampla gama de processos celulares, incluindo regulação do ciclo celular, apoptose e diferenciação. A PKC desempenha um papel crucial nas vias de transdução de sinais que influenciam a proliferação e sobrevivência celular. Inibir a PKC pode levar a alterações na progressão do ciclo celular, tornando esses inibidores valiosos na pesquisa relacionada ao câncer, neurobiologia e doenças cardiovasculares. Na CymitQuimica, oferecemos uma seleção diversificada de inibidores de PKC de alta qualidade para apoiar sua pesquisa em transdução de sinais, regulação do ciclo celular e desenvolvimento terapêutico.
Foram encontrados 126 produtos de "PKC"
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TPPB
CAS:TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).Fórmula:C27H30F3N3O3Pureza:97.71% - 98.00%Cor e Forma:SolidPeso molecular:501.54Ro 31-8220 Mesylate
CAS:Ro 31-8220 Mesylate (Bisindolylmaleimide IX mesylate) is a pan-PKC inhibitor, and also shows potent inhibition against MSK1, MAPKAP-K1b, S6K1, and GSK3β.Fórmula:C25H23N5O2S·CH4O3SPureza:98.79% - 99.02%Cor e Forma:SolidPeso molecular:553.65Ref: TM-T6643
1mg49,00€2mg64,00€5mg92,00€10mg150,00€25mg230,00€50mg319,00€100mg475,00€1mL*10mM (DMSO)133,00€Ingenol
CAS:Ingenol mebutate treats actinic keratosis, has anticancer properties, and may reactivate latent HIV.
Fórmula:C20H28O5Pureza:99.78% - 99.87%Cor e Forma:SolidPeso molecular:348.43PKCβ inhibitor 1
CAS:PKCβ inhibitor 1 (KUN79359)(KUN79359) is a potent, selective and ATP-competitive inhibitor of PKC isozymes(IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2,Fórmula:C24H21N5O2Pureza:99.33%Cor e Forma:SolidPeso molecular:411.46Ref: TM-T8376
1mg93,00€5mg255,00€10mg363,00€25mg552,00€50mg730,00€100mg998,00€500µg58,00€1mL*10mM (DMSO)225,00€Protein Kinase C 19-31 acetate
PKC 19-31 acetate, a serine-altered PKCa-derived PKC inhibitor, tests PKC activity.Fórmula:C69H122N26O18Pureza:>99.99%Cor e Forma:SolidPeso molecular:1603.9Hypericin
CAS:Hypericin (Cyclosan) is a natural anthraquinone compound. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant effects. Cost-effective and quality-assured.Fórmula:C30H16O8Pureza:98.90% - ≥98%Cor e Forma:Red-Coloured Anthraquinone-DerivativePeso molecular:504.44Ref: TM-T6S0923
1mg54,00€5mg120,00€10mg172,00€25mg341,00€50mg504,00€100mg705,00€500mg1.431,00€1mL*10mM (DMSO)133,00€Enzastaurin
CAS:Enzastaurin (LY317615) (LY317615) is an effective PKCβ selective inhibitor (IC50: 6 nM), 6- to 20-fold selectivity against PKCα/γ/ε.Fórmula:C32H29N5O2Pureza:98% - >99.99%Cor e Forma:SolidPeso molecular:515.6Ruboxistaurin hydrochloride
CAS:Ruboxistaurin HCl (LY 333531) selectively inhibits PKCβI/II with IC50 of 4.7/5.9 nM; much less effective on other PKC types and ATP-kinases.Fórmula:C28H28N4O3·HClPureza:99.14% - 99.28%Cor e Forma:SolidPeso molecular:505.01Ref: TM-T3689
1mg67,00€2mg87,00€5mg148,00€10mg244,00€25mg487,00€50mg702,00€100mg982,00€500mg1.963,00€1mL*10mM (DMSO)190,00€Ionomycin calcium
CAS:Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, exhibiting high specificity for calcium ions. Cost-effective and quality-assured.
Fórmula:C41H70CaO9Pureza:98% - 98.11%Cor e Forma:SolidPeso molecular:747.07PKCTheta-IN-2
CAS:PKCTheta-IN-2 (compound 14) is a potent and selective PKCθ inhibitor (IC50 = 0.25 nM) that suppresses IL-2 production in mice (IC50 = 682 nM).Fórmula:C24H23N5O2Pureza:99.38%Cor e Forma:SolidPeso molecular:413.47Phorbol 12,13-dibutyrate
CAS:Phorbol 12,13-dibutyrate (Phorbol dibutyrate) is a PKC activator that induces contraction of isolated rabbit vascular smooth muscle.Fórmula:C28H40O8Pureza:99.32% - 99.37%Cor e Forma:SolidPeso molecular:504.61Ref: TM-T16526
1mg58,00€5mg160,00€10mg268,00€25mg530,00€50mg827,00€100mg1.314,00€200mg1.773,00€1mL*10mM (DMSO)170,00€AJH-836
CAS:AJH-836 is a compound that activates Munc13-1 and PKC ε/α, demonstrating a dissociation constant (Kd) of 4.5 nM for PKCα, and facilitates the translocation ofFórmula:C22H38O5Pureza:98%Cor e Forma:SolidPeso molecular:382.53SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Fórmula:C17H22ClNO2SPureza:99.24% - 99.58%Cor e Forma:SolidPeso molecular:339.88PS315
CAS:PS315, a PS48 derivative, allosterically inhibits PKCζ/η (IC50: 10/30 μM), targeting aPKC's PIF-pocket, with anti-cancer properties.Fórmula:C23H19ClO2Pureza:98%Cor e Forma:SolidPeso molecular:362.85CGP60474
CAS:CGP60474 is an inhibitor of VEGFR-2 (IC50 = 84 nM) and an inhibitor of ATP-competitive PKC.Fórmula:C18H18ClN5OPureza:98.81%Cor e Forma:SolidPeso molecular:355.82Ref: TM-T14943
1mg34,00€2mg46,00€5mg71,00€10mg92,00€25mg177,00€50mg314,00€100mg518,00€1mL*10mM (DMSO)78,00€CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48Ref: TM-T10888
1mg57,00€5mg122,00€10mg192,00€25mg324,00€50mg459,00€100mg642,00€200mg888,00€1mL*10mM (DMSO)146,00€DCPLA-ME
CAS:DCPLA-ME (2-[(2-Pentylcyclopropyl)methyl]cyclopropaneoctanoic acid methyl ester) is the methyl ester form of DCPLA and can be used to treat neurodegenerativeFórmula:C21H38O2Pureza:99.80%Cor e Forma:SolidPeso molecular:322.53Ref: TM-T10980
1mg62,00€5mg126,00€10mg172,00€25mg350,00€50mg572,00€100mg772,00€200mg1.054,00€1mL*10mM (DMSO)138,00€NSC668394
CAS:NSC668394 is an ezrin phosphorylation inhibitor.NSC668394 has antitumor activity and increases ezrin cleavage.NSC668394 can be used to study tumor metastasis.Fórmula:C17H12Br2N2O3Pureza:99.29% - 99.29%Cor e Forma:SolidPeso molecular:452.1(-)-Indolactam V
CAS:(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.Fórmula:C17H23N3O2Pureza:98%Cor e Forma:SolidPeso molecular:301.38PKC-θ inhibitor 1
CAS:PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)Fórmula:C17H15F3N4OPureza:98%Cor e Forma:SolidPeso molecular:348.32VTX-27
CAS:VTX-27 is a selective inhibitor of protein kinase C θ (PKC θ) (Kis: 0.08 nM and 16 nM for PKC θ and PKC δ).Fórmula:C20H24ClFN6OPureza:99.84%Cor e Forma:SolidPeso molecular:418.9Ref: TM-T13314
1mg88,00€2mg118,00€5mg230,00€10mg344,00€25mg532,00€50mg740,00€100mg982,00€1mL*10mM (DMSO)213,00€TCS 21311
CAS:TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.Fórmula:C27H25F3N4O4Pureza:99.39% - ≥98%Cor e Forma:SolidPeso molecular:526.51PKC-IN-1
CAS:PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,Fórmula:C25H37FN8O2Pureza:98% - 98.79%Cor e Forma:SolidPeso molecular:500.61AS2521780
CAS:AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).Fórmula:C30H41N7OSPureza:98%Cor e Forma:SolidPeso molecular:547.76YAP/TAZ-TEAD-IN-2
YAP/TAZ-TEAD-IN-2 (Compound 51) is a YAP/TAZ-TEAD inhibitor that disrupts the interaction between YAP/TAZ and TEAD. It inhibits the transcriptional activity of TEAD with an IC50 of 1.2 nM. Additionally, YAP/TAZ-TEAD-IN-2 suppresses the expression of target genes (Cyr61, CTGF, AXL, and Survivin) and the proliferation of breast cancer cells.Fórmula:C19H20N2O3SCor e Forma:SolidPeso molecular:356.44Cercosporin
CAS:Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).Fórmula:C29H26O10Pureza:98%Cor e Forma:SolidPeso molecular:534.51
