ROCK
Os inibidores da quinase associada a Rho (ROCK) têm como alvo as quinases ROCK, que estão envolvidas na regulação do citoesqueleto, forma e motilidade celular. ROCK desempenha um papel significativo no controle da divisão celular, particularmente em processos como a citocinese. Inibir a ROCK pode levar a mudanças na dinâmica do ciclo celular, na motilidade celular e na apoptose, tornando esses inibidores valiosos na pesquisa do câncer, neurobiologia e estudos cardiovasculares. Na CymitQuimica, oferecemos uma seleção de inibidores ROCK de alta qualidade para apoiar sua pesquisa em biologia celular, dinâmica do citoesqueleto e mecanismos de doenças.
Foram encontrados 62 produtos para "ROCK".
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SR-3677
CAS:SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).Fórmula:C22H24N4O4Pureza:98.46%Cor e Forma:SolidPeso molecular:408.45Y-27632
CAS:Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II.Fórmula:C14H21N3OPureza:99.53% - 99.87%Cor e Forma:SolidPeso molecular:247.34RKI1313
CAS:RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasionFórmula:C17H16N4O2SPureza:99.70% - ≥95%Cor e Forma:White SolidPeso molecular:340.4Ref: TM-T2011
500µg50,00€1mg66,00€5mg135,00€1mL*10mM (DMSO)152,00€10mg197,00€25mg349,00€50mg512,00€100mg730,00€Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Cor e Forma:White SolidPeso molecular:307.37GSK269962A
CAS:GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.Fórmula:C29H30N8O5Pureza:99.14% - 99.71%Cor e Forma:Yellow SolidPeso molecular:570.6GSK429286A
CAS:GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Cor e Forma:SolidPeso molecular:432.37SAR407899 hydrochloride
CAS:SAR407899 hydrochloride is a selective, potent and ATP-competitive ROCK inhibitor, with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human andFórmula:C14H17ClN2O2Pureza:99.15%Cor e Forma:SolidPeso molecular:280.75SAR407899
CAS:SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.Fórmula:C14H16N2O2Pureza:99.42%Cor e Forma:White SolidPeso molecular:244.29Ref: TM-T7391
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg75,00€25mg128,00€50mg200,00€100mg319,00€200mg474,00€AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Cor e Forma:SolidPeso molecular:313.78ROCK-IN-2
CAS:ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.Fórmula:C18H13ClF2N6OPureza:97.29%Cor e Forma:SolidPeso molecular:402.79Ref: TM-TQ0110
1mg108,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg416,00€25mg670,00€50mg954,00€100mg1.288,00€Netarsudil mesylate
CAS:Netarsudil mesylate (AR-13324 mesylate) is a Rho-related protein kinase inhibitor used to study glaucoma and hypertension.Fórmula:C30H35N3O9S2Pureza:99.7%Cor e Forma:SolidPeso molecular:645.74Ref: TM-T10358L2
1mg34,00€5mg66,00€1mL*10mM (DMSO)96,00€10mg105,00€25mg236,00€50mg409,00€100mg700,00€Narciclasine
CAS:Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.Fórmula:C14H13NO7Pureza:98.16% - 99.58%Cor e Forma:White SolidPeso molecular:307.26ZINC00881524
CAS:ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.Fórmula:C21H20N2O3SPureza:99.48%Cor e Forma:SolidPeso molecular:380.46Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Cor e Forma:White SolidPeso molecular:327.83GSK-25
CAS:GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K, and a dramatically improved P450 profile.Fórmula:C24H16Cl2F2N6OPureza:99.29%Cor e Forma:SolidPeso molecular:513.33Ref: TM-T4488
1mg44,00€2mg56,00€5mg87,00€1mL*10mM (DMSO)89,00€10mg111,00€25mg168,00€50mg258,00€100mg430,00€HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Cor e Forma:White SolidPeso molecular:277.34Belumosudil
CAS:Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).Fórmula:C26H24N6O2Pureza:97.64% - 98.59%Cor e Forma:White SolidPeso molecular:452.51Ref: TM-T6867
2mg46,00€5mg70,00€1mL*10mM (DMSO)74,00€10mg95,00€25mg158,00€50mg236,00€100mg356,00€500mg848,00€Y-27632 dihydrochloride
CAS:View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.Fórmula:C14H21N3O·2HClPureza:97.96% - 99.98%Cor e Forma:SolidPeso molecular:320.26BDP5290
CAS:BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)Fórmula:C17H18ClN7OPureza:97.22%Cor e Forma:White SolidPeso molecular:371.82Ref: TM-T7301
1mg52,00€2mg77,00€5mg113,00€1mL*10mM (DMSO)124,00€10mg178,00€25mg369,00€50mg535,00€100mg780,00€Afuresertib
CAS:Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplasticFórmula:C18H17Cl2FN4OSPureza:97.51% - 99.51%Cor e Forma:SolidPeso molecular:427.32Ref: TM-T1911
1mg37,00€2mg52,00€5mg74,00€1mL*10mM (DMSO)74,00€10mg92,00€25mg166,00€50mg259,00€100mg452,00€500mg982,00€
