ROCK
Os inibidores da quinase associada a Rho (ROCK) têm como alvo as quinases ROCK, que estão envolvidas na regulação do citoesqueleto, forma e motilidade celular. ROCK desempenha um papel significativo no controle da divisão celular, particularmente em processos como a citocinese. Inibir a ROCK pode levar a mudanças na dinâmica do ciclo celular, na motilidade celular e na apoptose, tornando esses inibidores valiosos na pesquisa do câncer, neurobiologia e estudos cardiovasculares. Na CymitQuimica, oferecemos uma seleção de inibidores ROCK de alta qualidade para apoiar sua pesquisa em biologia celular, dinâmica do citoesqueleto e mecanismos de doenças.
Foram encontrados 62 produtos para "ROCK".
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H-1152
CAS:H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).Fórmula:C16H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:319.42Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Fórmula:C16H16N4OPureza:98%Cor e Forma:SolidPeso molecular:280.32SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Cor e Forma:SolidPeso molecular:415.28CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Cor e Forma:SolidPeso molecular:457.48Ref: TM-T36196
2mg34,00€5mg54,00€1mL*10mM (DMSO)54,00€10mg86,00€25mg172,00€50mg260,00€100mg411,00€200mg552,00€CID-5056270
CAS:CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphomaFórmula:C17H13N3O3SPureza:99.6%Cor e Forma:White SolidPeso molecular:339.37Ref: TM-T23888
1mg110,00€5mg250,00€1mL*10mM (DMSO)253,00€10mg349,00€25mg515,00€50mg702,00€100mg928,00€Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Fórmula:C12H13N3OPureza:99.87%Cor e Forma:SolidPeso molecular:215.25Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.8%Cor e Forma:Yellow SolidPeso molecular:352.5Ref: TM-T12721
1mg71,00€1mL*10mM (DMSO)105,00€5mg138,00€10mg205,00€25mg358,00€50mg502,00€100mg665,00€200mg893,00€AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Fórmula:C20H19N3O2Pureza:99.86%Cor e Forma:Yellow SolidPeso molecular:333.38Ref: TM-T22037
1mg49,00€5mg92,00€1mL*10mM (DMSO)109,00€10mg166,00€25mg358,00€50mg530,00€100mg758,00€200mg1.044,00€LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Fórmula:C23H29N7O3Pureza:99.08%Cor e Forma:SolidPeso molecular:451.52ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Fórmula:C18H12N6OSPureza:99.65%Cor e Forma:SolidPeso molecular:360.39Ref: TM-T12747
1mg50,00€5mg111,00€1mL*10mM (DMSO)136,00€10mg177,00€25mg304,00€50mg447,00€100mg692,00€200mg888,00€ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Cor e Forma:SolidPeso molecular:436.5Ref: TM-T14960
1mg73,00€5mg160,00€1mL*10mM (DMSO)173,00€10mg250,00€25mg430,00€50mg645,00€100mg888,00€ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Cor e Forma:SolidPeso molecular:327.4ROCK-IN-9
CAS:ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.Fórmula:C20H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.4ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Fórmula:C30H25FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:556.61H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:99.85%Cor e Forma:White SolidPeso molecular:392.34Ref: TM-T35328
1mg60,00€5mg135,00€1mL*10mM (DMSO)147,00€10mg215,00€25mg415,00€50mg655,00€100mg888,00€ROCK-IN-1
CAS:ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurologicalFórmula:C20H18FN3OPureza:99.80%Cor e Forma:Yellow SolidPeso molecular:335.37ROCK-IN-11
CAS:ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Fórmula:C22H20N4O4SCor e Forma:SolidPeso molecular:436.484ROCK2-IN-12
CAS:ROCK2-IN-12 (Compound A25) is a selective inhibitor of ROCK2, exhibiting an IC50 of 7.0 nM for ROCK2, demonstrating greater efficacy compared to ROCK1 inhibition. It exerts potent anti-fibrotic effects via the TGF-β/Smad and ROCK2/STAT3 signaling pathways. In a Bleomycin-induced mouse pulmonary fibrosis (PF) model, ROCK2-IN-12 significantly reduces collagen deposition and reverses fibrosis progression. This compound is applicable in research on pulmonary diseases such as lung fibrosis.Fórmula:C23H18FN9OPeso molecular:455.46Rhodblock 1a
CAS:Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.Fórmula:C20H16N2O2Cor e Forma:SolidPeso molecular:316.353
