ROCK
Os inibidores da quinase associada a Rho (ROCK) têm como alvo as quinases ROCK, que estão envolvidas na regulação do citoesqueleto, forma e motilidade celular. ROCK desempenha um papel significativo no controle da divisão celular, particularmente em processos como a citocinese. Inibir a ROCK pode levar a mudanças na dinâmica do ciclo celular, na motilidade celular e na apoptose, tornando esses inibidores valiosos na pesquisa do câncer, neurobiologia e estudos cardiovasculares. Na CymitQuimica, oferecemos uma seleção de inibidores ROCK de alta qualidade para apoiar sua pesquisa em biologia celular, dinâmica do citoesqueleto e mecanismos de doenças.
Foram encontrados 67 produtos de "ROCK"
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GSK429286A
CAS:<p>GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).</p>Fórmula:C21H16F4N4O2Pureza:97.68% - 98.49%Cor e Forma:SolidPeso molecular:432.37Y-27632 dihydrochloride
CAS:<p>View and buy Y-27632 dihydrochloride from TargetMol.Y-27632 is a selective inhibitor of ROCKs.Cited in 10 publications.</p>Fórmula:C14H21N3O·2HClPureza:97.96% - 99.98%Cor e Forma:SolidPeso molecular:320.26Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Cor e Forma:SolidPeso molecular:307.37Y-33075
CAS:Y-33075 (Y-39983 free base) is a ROCK inhibitor that lowers IOP, increases blood flow to ONH, and increases the number of RGCs with regenerating axons.Fórmula:C16H16N4OPureza:98%Cor e Forma:SolidPeso molecular:280.32SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Fórmula:C15H20Cl2N8O2Pureza:98%Cor e Forma:SolidPeso molecular:415.28CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Fórmula:C26H23N3O5Pureza:99.71%Cor e Forma:SolidPeso molecular:457.48H-1152
CAS:<p>H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).</p>Fórmula:C16H21N3O2SPureza:98%Cor e Forma:SolidPeso molecular:319.42AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Fórmula:C20H19N3O2Pureza:99.86%Cor e Forma:SolidPeso molecular:333.38Rhodblock 6
CAS:Rhodblock 6 is a Rho kinase inhibitor, blocking phosphorylated MRLC localization by targeting ROCK activity.Fórmula:C12H13N3OPureza:99.87%Cor e Forma:SolidPeso molecular:215.25CID-5056270
CAS:<p>CID-5056270 has anticancer activity and can inhibit lung cancer, anal cancer, bladder cancer, cervical cancer, vulvar cancer, penile cancer, Burkitt's lymphoma</p>Fórmula:C17H13N3O3SPureza:99.6%Cor e Forma:SolidPeso molecular:339.37Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Fórmula:C20H24N4SPureza:99.8%Cor e Forma:SolidPeso molecular:352.5CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Fórmula:C24H27Cl2N5SPureza:99.63%Cor e Forma:SolidPeso molecular:488.48ROCK-IN-7
CAS:ROCK-IN-7 (compound 9) serves as a ROCK kinase inhibitor and is utilized in the investigation of ocular conditions, including glaucoma and retinal diseases [1].Fórmula:C17H17N3O2SPureza:98%Cor e Forma:SolidPeso molecular:327.4Chroman 1
CAS:Chroman 1 is a potent inhibitor of ROCK1 (IC50 = 52 pM) and ROCK2 (IC50 = 1 pM).Fórmula:C24H28N4O4Pureza:99.67% - 99.84%Cor e Forma:SolidPeso molecular:436.5ROCK-IN-9
CAS:<p>ROCK-IN-9 (Compound T345), a ROCK inhibitor, exhibits cytotoxicity in HepG2 cells with an IC50 of 40.8 μM.</p>Fórmula:C20H20FN5O2Pureza:98%Cor e Forma:SolidPeso molecular:381.4ROCK2-IN-6 hydrochloride
CAS:ROCK2-IN-6 hydrochloride (Comp A)为一种选择性ROCK2抑制剂，适用于研究ROCK介导的疾病、自身免疫性病症与炎症。Fórmula:C26H22ClF2N7OPureza:98%Cor e Forma:SolidPeso molecular:521.95ROCK-IN-8
CAS:ROCK-IN-8 (Example 4), a ROCK inhibitor, exhibits anti-inflammatory properties and is suitable for respiratory and gastro-intestinal disease research,Fórmula:C30H25FN4O4SPureza:98%Cor e Forma:SolidPeso molecular:556.61ROCK2-IN-2
CAS:ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).Fórmula:C18H12N6OSPureza:99.65%Cor e Forma:SolidPeso molecular:360.39LX7101
CAS:LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).Fórmula:C23H29N7O3Pureza:99.08%Cor e Forma:SolidPeso molecular:451.52ROCK-IN-1
CAS:<p>ROCK-IN-1 is a potent ROCK inhibitor that inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM.ROCK-IN-1 can be used in the study of neurological</p>Fórmula:C20H18FN3OPureza:>99.99%Cor e Forma:SolidPeso molecular:335.37
