ROCK
Os inibidores da quinase associada a Rho (ROCK) têm como alvo as quinases ROCK, que estão envolvidas na regulação do citoesqueleto, forma e motilidade celular. ROCK desempenha um papel significativo no controle da divisão celular, particularmente em processos como a citocinese. Inibir a ROCK pode levar a mudanças na dinâmica do ciclo celular, na motilidade celular e na apoptose, tornando esses inibidores valiosos na pesquisa do câncer, neurobiologia e estudos cardiovasculares. Na CymitQuimica, oferecemos uma seleção de inibidores ROCK de alta qualidade para apoiar sua pesquisa em biologia celular, dinâmica do citoesqueleto e mecanismos de doenças.
Foram encontrados 67 produtos de "ROCK"
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H-1152 dihydrochloride
CAS:H-1152 2HCl: ROCK inhibitor, IC50=12 nM, Ki=1.6 nM. Blocks PKA, PKC, PKG, Aurora A, CaMKII with higher IC50s.Fórmula:C16H23Cl2N3O2SPureza:99.85%Cor e Forma:SolidPeso molecular:392.34ROCK-IN-11
CAS:ROCK-IN-11 (example 94) is an effective inhibitor of ROCK1 and ROCK2, with an IC50 of ≤ 5 μM, and plays a significant role in cancer research.Fórmula:C22H20N4O4SCor e Forma:SolidPeso molecular:436.484ROCK/HDAC-IN-1
<p>ROCK/HDAC-IN-1 (Compound 10h) serves as an orally effective inhibitor of ROCK/HDAC. This compound suppresses ROCK1/2 (IC50: 254.9 nM, 58.18 nM) and HDAC1/2/3/6/8 (IC50: 9.09, 8.03, 6.26, 0.41, 7.69 nM). It stimulates the activation of DAMPs, notably calreticulin (CRT) exposure and HMGB1 release, suggesting its potential as an inducer of immunogenic cell death (ICD). ROCK/HDAC-IN-1 exhibits antiproliferative effects against breast cancer cells (IC50: 0.37 μM for MDA-MB-231 cells), inhibits tumor growth, activates T cells, and shows no significant toxicity.</p>Fórmula:C19H22N4O3SCor e Forma:SolidPeso molecular:386.47Rhodblock 1a
CAS:<p>Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway, which disrupts the localization and function of proteins within the Rho pathway. This interference hinders the proper formation of the cleavage furrow during cell division, leading to some cells either failing to form the cleavage furrow or forming a ruptured furrow, resulting in binucleated cells. Rhodblock 1a can be utilized for investigating cell division mechanisms and holds potential for research into cardiovascular diseases and cancer.</p>Fórmula:C20H16N2O2Cor e Forma:SolidPeso molecular:316.353Zelasudil
CAS:<p>Zelasudil (RXC007) is a Rho-related (ROCK) kinase inhibitor for the study of idiopathic pulmonary fibrosis and inflammation.</p>Fórmula:C22H21F2N7OPureza:99.15%Cor e Forma:SolidPeso molecular:437.445ROCK2-IN-6
CAS:<p>ROCK2-IN-6 (Comp A) is a selective inhibitor of ROCK2, applicable in the study and treatment of ROCK-mediated, autoimmune, and inflammatory diseases [1].</p>Fórmula:C26H21F2N7OPureza:98%Cor e Forma:SolidPeso molecular:485.49ROCK-IN-6
CAS:<p>ROCK-IN-6, a selective ROCK2 inhibitor, exhibits potent inhibition with an IC50 of 2.19 nM and holds promise for research into glaucoma and retinal diseases [1</p>Fórmula:C19H19N5O8SPureza:98%Cor e Forma:SolidPeso molecular:477.45Ref: TM-T79077
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