HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 169 produtos de "HSP"
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HM03 trihydrochloride
CAS:<p>HM03 trihydrochloride is a potent and selective inhibitor of HSPA5, also known as Bip or Grp78. It exhibits anticancer activity.</p>Fórmula:C26H30Cl4N4O2Cor e Forma:SolidPeso molecular:572.35DTHIB
CAS:<p>DTHIB robustly inhibits the HSF1 cancer gene signature and prostate cancer cell proliferation.</p>Fórmula:C13H9ClFN3O3Pureza:98.86% - 99.29%Cor e Forma:SolidPeso molecular:309.68TRC051384 HCl
CAS:<p>TRC051384 is an inducer of heat shock protein Hsp70, activating heat shock factor-1 and enhancing Hsp72 expression in neurons and glial cells.</p>Fórmula:C25H32ClN5O4Pureza:97.55%Cor e Forma:SolidPeso molecular:502.01KNK437
CAS:<p>KNK437 (Heat Shock Protein Inhibitor I), a pan-HSP inhibitor, suppresses the synthesis of inducible HSPs(HSP105, HSP72, and HSP40).</p>Fórmula:C13H11NO4Pureza:98.90%Cor e Forma:SolidPeso molecular:245.23Ganetespib
CAS:<p>Ganetespib (STA-9090) is a synthetic small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity.</p>Fórmula:C20H20N4O3Pureza:98% - 99.95%Cor e Forma:SolidPeso molecular:364.4Pimitespib
CAS:<p>Pimitespib (TAS-116) is an ATP-competitive and highly specific HSP90α/HSP90β inhibitor (Kis: 34.7 nM and 21.3 nM, respectively).</p>Fórmula:C25H26N8OPureza:99.22% - 99.49%Cor e Forma:SolidPeso molecular:454.53HSP27 inhibitor J2
CAS:<p>HSP27 inhibitor J2 (J2) (J2) is a HSP27 inhibitor, inhibits a production of HSP27 giant polymers, thereby having an effect of inhibiting a chaperone function of</p>Fórmula:C13H12O4SPureza:99.51%Cor e Forma:SolidPeso molecular:264.3Palmitic acid
CAS:<p>Palmitic acid (Cetylic acid) is a natural product, a common saturated fatty acid found in animals, plants and microorganisms.</p>Fórmula:C16H32O2Pureza:99.17% - 99.67%Cor e Forma:White Crystalline Scales SolidPeso molecular:256.42Grp94 Inhibitor-1
CAS:<p>Grp94 Inhibitor-1 is a potent, selective Grp94 inhibitor (IC50 : 2 nM).</p>Fórmula:C22H28N2O2Pureza:97.02%Cor e Forma:SolidPeso molecular:352.47Geldanamycin
CAS:<p>Geldanamycin, an HSP90 inhibitor (Kd: 1.2 μM), specifically disrupts glucocorticoid receptor (GR)/HSP association.</p>Fórmula:C29H40N2O9Pureza:97.59% - 99.27%Cor e Forma:Yellow To Orange PowderPeso molecular:560.64Tanespimycin
CAS:<p>Tanespimycin (KOS 953) is an Hsp90 inhibitor (IC50=5 nM) and is selective. Tanespimycin depletes intracellular STK38/NDR1. High-Quality, Low-Cost!</p>Fórmula:C31H43N3O8Pureza:99.07% - 99.83%Cor e Forma:Dark Purple SolidPeso molecular:585.69Paeoniflorin
CAS:<p>Paeoniflorin (Peoniflorin) is a herbal constituent extracted from the root of Paeonia albiflora Pall.</p>Fórmula:C23H28O11Pureza:96.9% - 97.43%Cor e Forma:White Fine PowderPeso molecular:480.46Apoptozole
CAS:<p>Apoptozole (Apoptosis Activator VII) is an inhibitor of the ATPase domain of Hsc70 and Hsp70, and can induce apoptosis.</p>Fórmula:C33H25F6N3O3Pureza:99.75%Cor e Forma:SolidPeso molecular:625.56HA15
CAS:<p>HA15 targets BiP/GRP78/HSPA5, showing anti-cancer effects on all tested melanoma cells, resistant or patient-derived.</p>Fórmula:C23H22N4O3S2Pureza:99.77% - 99.86%Cor e Forma:SolidPeso molecular:466.58Eupalinolide A
CAS:<p>Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.</p>Fórmula:C24H30O9Pureza:98.82% - 99.22%Cor e Forma:SolidPeso molecular:462.49KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Cor e Forma:SolidPeso molecular:574.66Feretoside
CAS:<p>Feretoside is a natural product extracted from the barks of E. ulmoides. Feretoside shows inducible activity on the heat shock factor 1 (HSF1).</p>Fórmula:C17H24O11Pureza:99.85%Cor e Forma:SolidPeso molecular:404.37VER-49009
CAS:<p>VER-49009 (CCT 129397) is a potent Hsp90 inhibitor(IC50 of 25 nM and Kd of 78 nM).</p>Fórmula:C19H18ClN3O4Pureza:99.36% - 99.99%Cor e Forma:SolidPeso molecular:387.82DDO-5936
CAS:<p>DDO-5936 is a potent and specific HSP90-Cdc37 PPI inhibitor.</p>Fórmula:C25H29N5O4SPureza:99.81%Cor e Forma:SolidPeso molecular:495.59NVP-HSP990
CAS:<p>NVP-HSP990 (HSP990) is an effective and specific HSP90α/β inhibitor (IC50: 0.6 /0.8 nM).</p>Fórmula:C20H18FN5O2Pureza:98.03% - 99.32%Cor e Forma:SolidPeso molecular:379.39
