HSP
Os inibidores de proteínas de choque térmico (HSP) têm como alvo as HSPs, uma família de chaperonas moleculares que auxiliam no dobramento de proteínas, estabilidade e proteção contra danos induzidos por estresse. As HSPs são frequentemente superexpressas em células cancerígenas, ajudando-as a sobreviver em condições estressantes, como hipóxia e quimioterapia. Inibir as HSPs pode interromper esses mecanismos de proteção, levando à morte celular. Portanto, os inibidores de HSP são valiosos na terapia contra o câncer e na pesquisa de respostas ao estresse. Na CymitQuimica, oferecemos uma gama abrangente de inibidores de HSP de alta qualidade para apoiar sua pesquisa em homeostase de proteínas, respostas ao estresse e oncologia.
Foram encontrados 169 produtos de "HSP"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
KW-2478
CAS:<p>KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM.</p>Fórmula:C30H42N2O9Pureza:98.68% - 99.52%Cor e Forma:SolidPeso molecular:574.66Alvespimycin
CAS:<p>Alvespimycin (17-DMAG) is a potent Hsp90 inhibitor with potential anticancer activity, which acts by binding to Hsp90.</p>Fórmula:C32H48N4O8Pureza:99.88%Cor e Forma:SolidPeso molecular:616.75Calenduloside E
CAS:<p>Calenduloside E (Silphioside F) exhibits hypoglycemic activities by suppressing the transfer of glucose from the stomach to the small intestine and by</p>Fórmula:C36H56O9Pureza:96.16% - 98.99%Cor e Forma:SolidPeso molecular:632.8217-AEP-GA
CAS:<p>17-AEP-GA is an HSP90 antagonist and a potent inhibitor of glioblastoma cell proliferation, survival, migration and invasion.</p>Fórmula:C34H50N4O8Pureza:97.77% - 99.56%Cor e Forma:SolidPeso molecular:642.78Retaspimycin Hydrochloride
CAS:<p>Retaspimycin Hydrochloride is a potent and water-soluble Hsp90 inhibitor(Hsp90 and Grp9 with EC50s of 119 nM).</p>Fórmula:C31H46ClN3O8Pureza:98%Cor e Forma:SolidPeso molecular:624.17Bimoclomol
CAS:<p>Bimoclomol is a heat shock protein co-inducer used for the research of cardiovascular diseases.</p>Fórmula:C14H20ClN3O2Cor e Forma:SolidPeso molecular:297.78CH5138303
CAS:<p>CH5138303 is an orally available Hsp90 inhibitor with Kd of 0.48 nM.</p>Fórmula:C19H18ClN5O2SPureza:98%Cor e Forma:SolidPeso molecular:415.9AMP-PCP
CAS:<p>AMP-PCP is an ATP analog and can bind to the Hsp90 N-terminal domain (Kd: 3.8 μM). AMP-PCP binding favors the formation of the active homodimer of Hsp90.</p>Fórmula:C11H18N5O12P3Pureza:98%Cor e Forma:SolidPeso molecular:505.21JG-48
CAS:<p>JG-48 is an inhibitor of Hsp70. JG-48 suppresses phosphorylated and total Tau in cells, endogenous Tau in neuroblastoma cells.</p>Fórmula:C20H16F3N3OS2Cor e Forma:SolidPeso molecular:435.49Hsp90-IN-15
CAS:<p>Hsp90-IN-15: Hsp90 blocker with anticancer properties; halts S phase, triggers apoptosis, cuts Hsp90 in Hela cells.</p>Fórmula:C23H27F3N4Cor e Forma:SolidPeso molecular:416.48CCT251236
CAS:<p>CCT251236 is an orally available Pirin ligand obtained from a heat shock transcription factor 1 (hsf1) phenotypic screen.</p>Fórmula:C32H32N4O5Pureza:98.82% - 99.89%Cor e Forma:SolidPeso molecular:552.62HSP90-IN-12
CAS:<p>VAC, a potent anti-cancer vibsanin A analog, inhibits cell proliferation and affects HSP90 protein levels.</p>Fórmula:C25H36O4Cor e Forma:SolidPeso molecular:400.55YM-01 Tosylate
CAS:<p>YM-01 Tosylate, a potent antitumor agent, selectively targets cancer cells and overcoming tamoxifen resistance.</p>Fórmula:C27H27N3O4S3Cor e Forma:SolidPeso molecular:553.72Displurigen
CAS:<p>Displurigen is an inhibitor of ATPase activity of HSP70.</p>Fórmula:C15H10O4SPureza:98%Cor e Forma:SolidPeso molecular:286.3Malonganenone A
CAS:<p>Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity.</p>Fórmula:C26H38N4O2Cor e Forma:SolidPeso molecular:438.616BrCaQ
CAS:<p>6BrCaQ inhibits TRAP1, has antiproliferative effects, and is used in 6BrCaQ-TPP synthesis.</p>Fórmula:C18H15BrN2O3Cor e Forma:SolidPeso molecular:387.23HSP90-IN-22
CAS:<p>HSP90-IN-22 (Compound 35) is an Hsp90 inhibitor exhibiting antiproliferative activity, with IC50 values of 3.65 μM in MCF7 breast cancer cells and 2.71 μM in</p>Fórmula:C25H30N4O3Pureza:98%Cor e Forma:SolidPeso molecular:434.53PU3
CAS:<p>PU3 is an inhibitor of Hsp90.</p>Fórmula:C19H25N5O3Pureza:98%Cor e Forma:SolidPeso molecular:371.43SEW84
CAS:<p>SEW84, an Aha1-stimulated Hsp90 inhibitor, has an IC50 of 0.3 μM, aiding protein deposition disease research.</p>Fórmula:C19H14F4N4OSCor e Forma:SolidPeso molecular:422.4HSP90-IN-14
CAS:<p>HSP90-IN-14 inhibits Hsp90 (Kd=0.26 μM) and fights influenza A/H3N2, A/H1N1, B with EC50 of 2.6, 3.9, 17 μM in MDCK cells.</p>Fórmula:C14H8Cl2N4O4SCor e Forma:SolidPeso molecular:399.21
