Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2242 produtos de "Cromatina/Epigenética"
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MPT0G211 mesylate
CAS:<p>MPT0G211 mesylate: potent, selective HDAC6 inhibitor (IC50=0.291nM), oral, BBB-penetrating, anti-tau and metastasis, potential anticancer.</p>Fórmula:C18H19N3O5SCor e Forma:SolidPeso molecular:389.43CPI203
CAS:<p>CPI203 (CPI 203) is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).</p>Fórmula:C19H18ClN5OSPureza:99.13% - 99.77%Cor e Forma:SolidPeso molecular:399.9ZM-447439
CAS:<p>ZM 447439 selectively inhibits Aurora A/B (IC50: 110/130 nM); 8x less effective on MEK1, Src, Lck; minimal impact on CDK1/2/4, Plk1, Chk1.</p>Fórmula:C29H31N5O4Pureza:99.11% - 99.59%Cor e Forma:Pale Yellow SolidPeso molecular:513.59Pacritinib
CAS:<p>Pacritinib (SB1518) (SB1518) is an effective and specific inhibitor of JAK2 and FLT3 (IC50: 23/22 nM, in cell-free assays).</p>Fórmula:C28H32N4O3Pureza:99.25% - 99.49%Cor e Forma:SolidPeso molecular:472.58MRTX-1719
CAS:<p>MRTX-1719 is a potent and selective inhibitor of the PRMT5/MTA complex with an IC50 value of <10 nM against PRMT5/MTAMTAPDELSDMA cell lines.Cost-effective and quality-assured.</p>Fórmula:C23H18ClFN6O2Pureza:98.27% - 99.18%Cor e Forma:SolidPeso molecular:464.88Bisindolylmaleimide IV
CAS:<p>Bisindolylmaleimide IV is a protein kinase C (PKC) cell permeable inhibitor( IC50 : 0.10 - 0.55 μM)</p>Fórmula:C20H13N3O2Pureza:98.83%Cor e Forma:Dark Red SolidPeso molecular:327.34AT-9283 HCl
CAS:<p>AT-9283, a multi-targeted kinase inhibitor, is used potentially for the treatment of multiple myeloma.</p>Fórmula:C19H24ClN7O2Cor e Forma:SolidPeso molecular:417.89AZ6102
CAS:<p>AZ6102: Potent TNKS1/2 inhibitor, 100x selective over PARPs, IC50 = 5 nM in DLD-1 Wnt pathway.</p>Fórmula:C25H28N6OPureza:97.98% - 99.91%Cor e Forma:SolidPeso molecular:428.53OAC1
CAS:<p>OAC1 (BAS 00287861) activates Oct4, boosts iPSC efficiency, and speeds up reprogramming.</p>Fórmula:C14H11N3OPureza:99.49% - 99.65%Cor e Forma:SolidPeso molecular:237.26Fraxinellone
CAS:<p>1.</p>Fórmula:C14H16O3Pureza:99.35% - 99.92%Cor e Forma:SolidPeso molecular:232.27dencichine
CAS:<p>Dencichine (ODAP) is a neurotoxic agent and a haemostatic agent, which relates to modulation of the coagulation system, and fibrinolytic system.</p>Fórmula:C5H8N2O5Pureza:99.93% - ≥95%Cor e Forma:SolidPeso molecular:176.13TP-064
CAS:<p>TP-064: Potent, selective PRMT4 inhibitor, IC50 < 10nM for H3 methylation, 100x selectivity, blocks MED12 methylation at 43nM.</p>Fórmula:C28H34N4O2Pureza:97.85%Cor e Forma:SolidPeso molecular:458.6SGC-SMARCA-BRDVIII
CAS:<p>SGC-SMARCA-BRDVIII is a potent and selective inhibitor of SMARCA2, SMARCA4, PB1(2), PB1(3) and PB1(5) with Kds of 35 nM, 36 nM, 3.7 μM, 2.0 μM and 13 nM,</p>Fórmula:C19H25N5O3Pureza:99.54% - 99.92%Cor e Forma:SolidPeso molecular:371.43Pim1/AKK1-IN-1
CAS:<p>Pim1/AKK1-IN-1: LKB1/AAK1 inhibitor with Kd 35/53/75/380 nM for Pim1/AKK1/MST2/LKB1, also targets MPSK1, TNIK.</p>Fórmula:C20H13N5OPureza:97.03% - 98.69%Cor e Forma:SolidPeso molecular:339.35Hispidulin
CAS:<p>Hispidulin, a natural flavone with a broad spectrum of biological activities, is a Pim-1 inhibitor (IC50: 2.71 μM).</p>Fórmula:C16H12O6Pureza:98.53% - 99.87%Cor e Forma:SolidPeso molecular:300.264'-Methoxychalcone
CAS:<p>4'-Methoxychalcone with a variety of pharmacological activities, such as anti-tumor and anti-inflammatory activities.</p>Fórmula:C16H14O2Pureza:99.86%Cor e Forma:SolidPeso molecular:238.28Iniparib
CAS:<p>Iniparib (BSI-201) (BSI-201) , a PARP1 inhibitor, exhibits potency in triple-negative breast Y (TNBC).</p>Fórmula:C7H5IN2O3Pureza:98.93%Cor e Forma:SolidPeso molecular:292.03CPI-1205
CAS:<p>CPI-1205 是一种高效的选择性 EZH2 抑制剂（IC50：0.002 μM，EC50：0.032 μM）。</p>Fórmula:C27H33F3N4O3Pureza:98.71% - 99.7%Cor e Forma:SolidPeso molecular:518.57AZD5305
CAS:<p>AZD5305 is a potent, selective and oral active PARP inhibitor.</p>Fórmula:C22H26N6O2Pureza:98.68% - 99.93%Cor e Forma:SolidPeso molecular:406.48RK-287107
CAS:<p>RK-287107 is an effective and specific inhibitor of tankyrase (IC50s: 14.3 and 10.6 nM for tankyrase-1 and tankyrase-2, respectively).</p>Fórmula:C22H26F2N4O2Pureza:99.64%Cor e Forma:SolidPeso molecular:416.46BD750
CAS:<p>BD750 is an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation(IC50 of 1.5 μM and 1.1 μM in</p>Fórmula:C14H13N3OSPureza:99.02%Cor e Forma:SolidPeso molecular:271.34EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Cor e Forma:SolidPeso molecular:369.4Remodelin hydrobromide
CAS:<p>Remodelin hydrobromide (Remodelin HBR) is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10.</p>Fórmula:C15H15BrN4SPureza:97.22% - 99.84%Cor e Forma:SolidPeso molecular:363.275TCS7010
CAS:<p>TCS7010 (Aurora A Inhibitor I) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay.</p>Fórmula:C31H31ClFN7O2Pureza:98.49% - 99.62%Cor e Forma:SolidPeso molecular:588.072,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS:<p>2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046), a potent lead analog, has good kinase selectivity and physicochemical properties.</p>Fórmula:C16H13Cl2N3O2Pureza:98.77%Cor e Forma:SolidPeso molecular:350.2GN44028
CAS:<p>GN44028 is a HIF-1 inhibitor with an IC50 of 14 nM, stopping HIF-1α activity but not mRNA or protein levels, or dimerization.</p>Fórmula:C18H15N3O2Pureza:99.52%Cor e Forma:SolidPeso molecular:305.33AZ505
CAS:<p>AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).</p>Fórmula:C29H38Cl2N4O4Pureza:98.18%Cor e Forma:SolidPeso molecular:577.54Phthalazinone pyrazole
CAS:<p>Phthalazinone pyrazole: a potent, selective oral Aurora-A kinase inhibitor, overexpressed in tumors with oncogenic activity.</p>Fórmula:C18H15N5OPureza:97.03%Cor e Forma:SolidPeso molecular:317.34Reversine
CAS:<p>Reversine, a small synthetic purine analogue (2, 6-disubstituted purine), is a potent inhibitior of Aurora A/B/C(IC50s=150-500 nM).</p>Fórmula:C21H27N7OPureza:98% - 98.42%Cor e Forma:SolidPeso molecular:393.49MLN8054
CAS:<p>MLN8054 is a potent and selective Aurora A kinase inhibitor with an IC50 of 4 nM.</p>Fórmula:C25H15ClF2N4O2Pureza:98.07% - 98.26%Cor e Forma:SolidPeso molecular:476.86WHI-P97
CAS:<p>WHI-P97 is a rationally designed potent inhibitor of JAK-3.</p>Fórmula:C16H13Br2N3O3Pureza:99.93%Cor e Forma:SolidPeso molecular:455.1JQ-1 (carboxylic acid)
CAS:<p>JQ-1 (carboxylic acid) is a cell-permeable BRD4 inhibitor with IC50s of 77 nM for BRD4(1) and 33 nM for BRD4(2)</p>Fórmula:C19H17ClN4O2SPureza:99.14% - 99.9%Cor e Forma:SolidPeso molecular:400.88γ-Oryzanol
CAS:<p>γ-Oryzanol (Gamma-Oryzanol) is a natural nutrient extract isolated from rice bran oil that contains a mixture of sterols and ferulic acids, which may aid in the</p>Fórmula:C40H58O4Pureza:mixture - mixtureCor e Forma:White Or White Crystalline Powder OdourlessPeso molecular:602.91,5-Isoquinolinediol
CAS:<p>1,5-Isoquinolinediol, a PARP1 inhibitor (IC50: 0.39 μM), is used in DNA repair and cell death studies.</p>Fórmula:C9H7NO2Pureza:98.29% - 99.35%Cor e Forma:Of White To White PowderPeso molecular:161.16GSK1379725A
CAS:<p>GSK1379725A is a selective BPTF ligand (Kd = 2.8 μM).</p>Fórmula:C23H23FN6O3Pureza:99.51%Cor e Forma:SolidPeso molecular:450.47666-15
CAS:<p>666-15 is a selective CREB inhibitor with an IC50 of 81 nM. 666-15 can effectively inhibit the growth of breast cancer.Cost-effective and quality-assured.</p>Fórmula:C33H31Cl2N3O5Pureza:99.41% - 99.88%Cor e Forma:SolidPeso molecular:620.52Bromosporine
CAS:<p>Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.</p>Fórmula:C17H20N6O4SPureza:99.65% - 99.79%Cor e Forma:SolidPeso molecular:404.44dCBP-1
CAS:<p>dCBP-1 selectively degrades p300/CBP via CRBN, killing multiple myeloma cells.</p>Fórmula:C51H63F2N11O10Pureza:98.21% - 99.12%Cor e Forma:SolidPeso molecular:1028.11Upadacitinib
CAS:<p>Upadacitinib (ABT-494), a selective JAK1 inhibitor, is researched for autoimmune diseases; IC50: 43 nM.</p>Fórmula:C17H19F3N6OPureza:98.96% - 99.94%Cor e Forma:SolidPeso molecular:380.37Ruboxistaurin mesylate
CAS:<p>Ruboxistaurin: PKC beta inhibitor, eases oxidative stress, heart issues & nephropathy in diabetic rats, halts retinal neovascularization.</p>Fórmula:C29H32N4O6SPureza:98%Cor e Forma:SolidPeso molecular:564.65UNC1999
CAS:<p>UNC1999 is a orally bioavailable, effective and specific inhibitor of EZH2 (IC50=2 nM) and EZH1 (IC50=45).</p>Fórmula:C33H43N7O2Pureza:99.19% - >99.99%Cor e Forma:SolidPeso molecular:569.74Pyridone 6
CAS:<p>Pyridone 6, a selective JAK1/2/3 and Tyk2 inhibitor with IC50s: JAK1=15 nM, JAK2=1 nM, JAK3 (Ki=5 nM), Tyk2=1 nM; weakly binds other kinases (130 nM-10 μM).</p>Fórmula:C18H16FN3OPureza:97.1% - 98.74%Cor e Forma:SolidPeso molecular:309.348-CHLOROQUINAZOLIN-4(1H)-ONE
CAS:<p>8-CHLOROQUINAZOLIN-4(1H)-ONE is inhibitor of Poly [ADP-ribose] polymerase 1 (human)</p>Fórmula:C8H5ClN2OPureza:98.79%Cor e Forma:SolidPeso molecular:180.59ICG001
CAS:ICG001 antagonizes Wnt signaling, binds CBP with 3 μM IC50, not p300.Fórmula:C33H32N4O4Pureza:99.06% - 99.95%Cor e Forma:SolidPeso molecular:548.63(R)-(-)-JQ1 Enantiomer
CAS:<p>(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)</p>Fórmula:C23H25ClN4O2SPureza:99.38%Cor e Forma:SolidPeso molecular:456.99JQEZ5
CAS:<p>JQEZ5 is an inhibitor of EZH2 lysine methyltransferase (IC50 = 11.1 nM).</p>Fórmula:C30H38N8O2Pureza:98.14% - ≥98%Cor e Forma:SolidPeso molecular:542.68Rucaparib hydrochloride
CAS:<p>Rucaparib hydrochloride (AG014699) is an oral PARP inhibitor with Ki 1.4 nM for PARP1 and hinders H6PD, studied in CRPC research.</p>Fórmula:C19H19ClFN3OCor e Forma:SolidPeso molecular:359.83XMD8-92
CAS:<p>XMD8-92 is an effective and specific BMK1/ERK5 inhibitor (Kd: 80 nM).</p>Fórmula:C26H30N6O3Pureza:98.21%Cor e Forma:SolidPeso molecular:474.554-amino-1,8-Naphthalimide
CAS:<p>4-amino-1,8-Naphthalimide (4-ANI) is a PARP inhibitor with IC50 of 180 nM</p>Fórmula:C12H8N2O2Pureza:95.13%Cor e Forma:Yellow Solid PowderPeso molecular:212.2Rucaparib acetate
CAS:<p>Rucaparib acetate, an oral PARP-1, -2, -3 inhibitor (Ki 1.4 nM for PARP1), also moderately inhibits H6PD; promising for CRPC research.</p>Fórmula:C21H22FN3O3Cor e Forma:SolidPeso molecular:383.423
