Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2598 produtos para "Cromatina/Epigenética".
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AURKA-IN-4
CAS:AURKA-IN-4 is an AURKA inhibitor, which can inhibit the proliferation of tumor cells.Fórmula:C12H17NO3Pureza:99.98%Cor e Forma:Brown SolidPeso molecular:223.27ZXH-3-26
CAS:ZXH-3-26 is a PROTAC composed of a Cereblon ligand, an E3 ubiquitin ligase, and a BRD4 ligand that can be used to study cancer.Fórmula:C38H37ClN8O7SPureza:98.90% - 98.90%Cor e Forma:SolidPeso molecular:785.27Sirtuin modulator 5
CAS:Sirtuin modulator 5 activates SIRT1 (<50 μM DC50), may extend cell lifespan, and could aid in researching various age/stress-related diseases.Fórmula:C24H23N3O4Cor e Forma:SolidPeso molecular:417.46SNIPER(BRD)-1
CAS:SNIPER(BRD)-1 has LCL-161, (+)-JQ1 linked; degrades BRD4, cIAP1/2, XIAP; IC50s: 6.8, 17, 49nM.Fórmula:C53H66ClN9O8S2Pureza:98%Cor e Forma:SolidPeso molecular:1056.73PTD2
PTD2 (Ac-Gly-Val-Nle-Arg-Ile-NH2) serves as a potent and selective WHSC1 inhibitor, exhibiting micromolar affinity for this target [1].Cor e Forma:Odour SolidSKLB-03220
CAS:SKLB-03220 is an oral covalent EZH2 inhibitor, abolishing H3K27me3 marks and serving as a potent small-molecule tool for cancer epigenetics research.Fórmula:C33H40N4O4Pureza:97.01%Cor e Forma:SoildPeso molecular:556.71JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.Fórmula:C43H51ClN8O3S2Cor e Forma:SolidPeso molecular:827.5LLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Cor e Forma:Odour SolidG9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Cor e Forma:Odour SolidSW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Fórmula:C44H64N6O9Pureza:98%Cor e Forma:SolidPeso molecular:821.01WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576PRMT5-IN-43
CAS:PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Fórmula:C22H17ClF3N5O2Cor e Forma:SolidPeso molecular:475.85UNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Fórmula:C49H71F3N6O10Cor e Forma:SolidPeso molecular:961.12UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09TEC 4
TEC 4 is a ByeTAC (bypass E3 ligase targeting chimera) that acts as a BRD4 degrader. At a concentration of 500 nM, it results in 33% residual BRD4 in Ramos B cells. Additionally, TEC 4 exhibits toxicity in Ramos B cells with an IC50 of 30.5 nM. ByeTAC recruits proteins directly to the proteasome for degradation by interacting with Rpn-13.Cor e Forma:Odour SolidPROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Fórmula:C41H42N10O6Pureza:98%Cor e Forma:SolidPeso molecular:770.84Ref: TM-T12559
50mgA consultar100mgA consultar5mg359,00€10mg567,00€1mL*10mM (DMSO)573,00€25mg1.054,00€HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFórmula:C27H41Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:570.55UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Fórmula:C27H37Cl3N8O4Pureza:98%Cor e Forma:SoildPeso molecular:644.0Ref: TM-T10699L2
200mgA consultar500mgA consultar2mg131,00€5mg187,00€1mL*10mM (DMSO)264,00€10mg283,00€50mg665,00€100mg1.034,00€Anemonin
CAS:Anemonin, a furanone dimer from Buttercups, may help manage melanocytes and osteoarthritis.Fórmula:C10H8O4Cor e Forma:SolidPeso molecular:192.17PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2GNE-987
CAS:GNE-987 is a potent chimeric BET degrader, binding BRD4 BD1/BD2 at IC50: 4.7/4.4 nM & has a DC50: 0.03 nM in EOL-1 AML cells.Fórmula:C56H67F2N9O8S2Pureza:99.22%Cor e Forma:White SolidPeso molecular:1096.31TAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Fórmula:C23H22Cl2FN5O3Pureza:99.65%Cor e Forma:White SolidPeso molecular:506.36Ref: TM-T34787
1mg92,00€5mg222,00€1mL*10mM (DMSO)248,00€10mg358,00€25mg710,00€50mg1.108,00€100mg1.558,00€PROTAC BRD4 Degrader-30
PROTACBRD4 degrader-30 is an ISOX-DUAL-based PROTAC degrader, targeting BRD4 with an IC50 value of 65 nM. It is used in research studies related to c-Myc oncoproteins and the pathophysiology of cancer cells.Cor e Forma:Odour SolidMAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:White SolidPeso molecular:412.85SR-0813
CAS:SR-0813 is a potent and selective inhibitor of the YEATS domain in ENL/AF9.Fórmula:C25H32N6O3SPureza:98.81%Cor e Forma:White SolidPeso molecular:496.62Ref: TM-T40229
1mg39,00€5mg86,00€1mL*10mM (DMSO)94,00€10mg124,00€25mg253,00€50mg384,00€100mg532,00€200mg705,00€PROTAC BET Degrader-1
CAS:PROTAC BET Degrader-1 is a potent degrader of BET based on PROTAC.Fórmula:C44H45N11O9Pureza:98%Cor e Forma:SolidPeso molecular:871.9Ref: TM-T13849
50mgA consultar100mgA consultar5mg410,00€1mL*10mM (DMSO)447,00€10mg627,00€25mg1.378,00€CW-3308
CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.Fórmula:C45H48N6O8Cor e Forma:SolidPeso molecular:800.9Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Cor e Forma:White SolidPeso molecular:587.54J27644
J27644 is a potent HDAC (histone deacetylase) inhibitor that mitigates TGF-β (transforming growth factor beta)-induced pulmonary fibrosis [1].Fórmula:C16H12ClN3O4Pureza:98%Cor e Forma:SolidPeso molecular:345.74CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Fórmula:C25H22Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:557.45EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35Dihydrochlamydocin
CAS:Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.65Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Fórmula:C10H3ClF3NO4Cor e Forma:SolidPeso molecular:293.58MAT2A-IN-15
MAT2A-IN-15 (compound 8) serves as an inhibitor of MAT2A.Fórmula:C36H32Cl2N6O2Cor e Forma:SolidPeso molecular:650.19638Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Fórmula:C56H110N22O14Pureza:98%Cor e Forma:SolidPeso molecular:1315.61LSD1/HDAC6-IN-1
LSD1/HDAC6-IN-1 is an oral dual inhibitor of LSD1/HDAC6 with anti-tumor effects, useful for multiple myeloma research.Cor e Forma:SolidPROTAC SMARCA2/4-degrader-29
CAS:PROTAC SMARCA2/4-degrader-29 (Compound I-279) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. In A549 cells, this compound effectively degrades SMARCA2 with a DC50 value of less than 100 nM, and similarly degrades SMARCA4 in MV411 cells with a DC50 under 100 nM.Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Fórmula:C41H41F4N7O11Cor e Forma:SolidPeso molecular:883.8PRMT5-IN-9
CAS:PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495BET-IN-26
BET-IN-26 (compound 13a) is a potent, selective, and orally active BD1 inhibitor, exhibiting IC50 values of 0.0055 µM for BD1 and 9.0 µM for BD2. It effectively reduces serum IL-6 and MCP-1 levels induced by LPS.Fórmula:C26H36N6O2SCor e Forma:SolidPeso molecular:496.26205PROTAC SMARCA2/4-degrader-26
PROTAC SMARCA2/4-degrader-26 is a PROTAC targeting the SMARCA2/4 proteins. It is composed of the ligand for PROTAC targeting proteins, 2-(4-(3-Amino-6-(2-hydroxyphenyl)pyridazin-4-yl)piperazin-1-yl)acetic acid, an E3 ligase component (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, and a PROTAC linker (S)-2-Amino-3,3-dimethylbutanoic acid. The coupled complex of the E3 ubiquitin ligase ligand + Linker is referred to as (S,R,S)-AHPC.Fórmula:C38H47N9O5SCor e Forma:SolidPeso molecular:741.9PROTAC SMARCA2/4-degrader-27
CAS:PROTAC SMARCA2/4-degrader-27 (PROTAC 2) serves as a targeted degrader, utilizing PROTAC technology to degrade both SMARCA2 and SMARCA4.Fórmula:C49H58FN9O6SCor e Forma:SolidPeso molecular:920.11GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Fórmula:C24H32ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:474AURKA against 1
Compound Ac13, also termed AURKA against 1, acts as an inhibitor of the Aurora kinase (AURKA) with an IC50 of less than 0.5 nM, targeting the acetylation of endogenous lysine (K162) and exhibiting anti-tumor cell proliferation activity. The kinase activity of AURKA, acetylated at K162 and induced by AURKA against 1, is reversibly restored in HCT116 cells transfected with SIRT3.Fórmula:C28H32FN9O2Cor e Forma:SolidPeso molecular:545.61PROTAC SMARCA2/4-degrader-31
CAS:PROTAC SMARCA2/4-degrader-31 (Compound I-280) serves as a degrader for the catalytic subunits SMARCA2 and SMARCA4 of the SWI/SNF complex. It effectively degrades SMARCA2 in A549 cells and SMARCA4 in MV411 cells, both with a degradation concentration (DC50) of less than 100 nM.Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95LO-3-62
LO-3-62 is a SMARCA2/4 degrader with PROTAC characteristics, featuring a truncated fumaramide group. It effectively induces the degradation of SMARCA2/4 within cells.PROTAC SMARCA2/4-degrader-25
PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06PROTAC SMARCA2/4-degrader-30
CAS:Compound I-291, also known as PROTAC SMARCA2/4-degrader-30, targets the catalytic subunits of the SWI/SNF complex, specifically SMARCA2 and SMARCA4. It effectively degrades SMARCA2 in A549 and MV411 cells, as well as SMARCA4 in MV411 cells, with a degradation concentration (DC50) of less than 100 nM.Fórmula:C44H51N11O4Cor e Forma:SolidPeso molecular:797.95SMARCA2 degrader-17
CAS:SMARCA2 degrader-17 is a degrader of SMARCA2, exhibiting synergistic antiproliferative effects with Adagrasib in cancer cells and capable of inhibiting tumor growth.Fórmula:C47H58N10O6SCor e Forma:SolidPeso molecular:891.09
