Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2623 produtos de "Cromatina/Epigenética"
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CMP-5
CAS:CMP-5 is a PRMT5 inhibitor with antiviral activity, inhibits PRMT5 methyltransferase activity, and can be used in the study of SARS virus infection.Fórmula:C21H21N3Pureza:98.68%Cor e Forma:SolidPeso molecular:315.41Ref: TM-T10850
1mg44,00€5mg92,00€1mL*10mM (DMSO)101,00€10mg137,00€25mg225,00€50mg334,00€100mg494,00€500mg1.054,00€JAK1-IN-8
CAS:JAK1-IN-8, a specific inhibitor of Janus kinase 1 (JAK1, IC50<500 nM).
Fórmula:C22H23FN4O3SPureza:98.4%Cor e Forma:SolidPeso molecular:442.51ACY-957
CAS:ACY-957: Oral HDAC1/2 inhibitor (IC50: HDAC1=7nM, HDAC2=18nM, HDAC3=1300nM); inactive on HDAC4/5/6/7/8/9.Fórmula:C24H23N5OSPureza:99.79%Cor e Forma:SolidPeso molecular:429.54Ref: TM-T10245
1mg90,00€2mg136,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg281,00€25mg432,00€50mg612,00€100mg802,00€DC-BPi-03
CAS:DC-BPi-03 is a potent BPTF-BRD inhibitor with an IC 50 of 698.3 nM and a K d of 2.81 μM .Fórmula:C14H14N4O2SPureza:98.96%Cor e Forma:SolidPeso molecular:302.35JAK-IN-31
CAS:JAK-IN-31 (Example 75), a JAK inhibitor, demonstrates IC50 values of ≤0.01 µM for JAK1, ≤0.01 µM for JAK2, 0.01-0.1 µM for JAK3, and ≤0.01 µM for Tyk2,Fórmula:C21H19N7O2S2Pureza:98%Cor e Forma:SolidPeso molecular:465.55MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Fórmula:C22H23F2N7OSPureza:98%Cor e Forma:SolidPeso molecular:471.53DY-46-2
CAS:DY-46-2 is a DNMT3A inhibitor (IC50: 0.39 ± 0.23 μM) with anticancer activity and is used in cancer and tumor research.Fórmula:C19H22N6O5SPureza:99.12% - 99.12%Cor e Forma:SolidPeso molecular:446.48CBB1007 hydrochloride
CAS:CBB1007 Hcl inhibits LSD1 selectively (IC50=5.27μM), blocks H3K4 demethylation, activates genes; less effect on other cells/tissues.Fórmula:C27H39Cl5N8O4Cor e Forma:SoildPeso molecular:716.91Nezulcitinib
CAS:Nezulcitinib (TD-0903) is an inhaled pan-JAK inhibitor targeting COVID-19-related acute lung injury.Fórmula:C30H37N7O2Cor e Forma:SolidPeso molecular:527.66PI3K/HDAC-IN-2
CAS:PI3K/HDAC-IN-2: dual inhibitor with IC50s - PI3Kα: 226nM, β: 279nM, γ: 467nM, δ: 29nM; HDAC1: 1.3nM. Selective to PI3Kδ/class I/IIb HDAC, anticancer.Fórmula:C23H23N7O4Cor e Forma:SolidPeso molecular:461.47FT895
CAS:FT895 is a selective and potent HDAC11 inhibitor with antifungal and antitumor activity that inhibits HDAC11 expression and limits EV71 replication in vitro.Fórmula:C16H15F3N4O2Pureza:98.95% - >99.99%Cor e Forma:SolidPeso molecular:352.31Ref: TM-T11329
1mg92,00€5mg219,00€1mL*10mM (DMSO)241,00€10mg339,00€25mg570,00€50mg795,00€100mg1.108,00€KDM5-C70
CAS:KDM5-C70 is an ethyl ester derivative of KDM5-C49.Fórmula:C17H28N4O3Pureza:97.63% - 99.86%Cor e Forma:SolidPeso molecular:336.43Ref: TM-T15648
2mg42,00€5mg58,00€1mL*10mM (DMSO)70,00€10mg84,00€25mg133,00€50mg233,00€100mg464,00€200mg663,00€500mg1.018,00€ARTD3/PARP3-IN-1
CAS:ARTD3/PARP3-IN-1 is a non-selective inhibitor targeting diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3)/PARP3 [1].Fórmula:C17H16N4O2Cor e Forma:SolidPeso molecular:308.33Sirtuin-1 inhibitor 1
CAS:Sirtuin-1 inhibitor 1 is an inhibitor against deacetylase-1 (Sirtuin-1) and can be used to study senescence and cell death in the organism.Fórmula:C20H17N3O2Pureza:99.1%Cor e Forma:SolidPeso molecular:331.37BRD7-IN-1
CAS:BRD7-IN-1, a BI7273 derivative, forms PROTAC VZ185, targeting BRD7/9 with DC50s of 4.5/1.8 nM via VHL ligand linkage.Fórmula:C22H28Cl2N4O3Pureza:98.95%Cor e Forma:SolidPeso molecular:467.39Ref: TM-T17697
1mg94,00€2mg137,00€5mg222,00€1mL*10mM (DMSO)227,00€10mg334,00€25mg602,00€50mg893,00€100mg1.243,00€200mg1.693,00€MS31
CAS:MS31 is a potent and highly affinity inhibitor of spindlin 1 (SPIN1).Fórmula:C20H27N3O2Pureza:98%Cor e Forma:SolidPeso molecular:341.45Aurora kinase inhibitor-8
CAS:Aurora kinase inhibitor-8 is a highly selective inhibitor of Aurora kinase.Fórmula:C30H29N7O3Cor e Forma:SolidPeso molecular:535.6PHD-IN-1
CAS:PHD-IN-1 (compound 80) serves as a potent PHD2 inhibitor, exhibiting an IC50 value of ≤5 nM.Fórmula:C24H23N7O2Pureza:98%Cor e Forma:SolidPeso molecular:441.49Upadacitinib tartrate
CAS:Upadacitinib: potent, selective JAK1 inhibitor, 74x preferential to JAK2, effective in rat arthritis.Fórmula:C21H33F3N6O11Pureza:98%Cor e Forma:SolidPeso molecular:602.521Pim-1 kinase inhibitor 5
CAS:Pim-1 kinase inhibitor 5 (Compound 4c), with an IC50 of 0.61 μM, exhibits cytotoxicity against various cancer cell lines, including HepG2, MCF-7, PC3, and HCT-Fórmula:C22H13Cl2N3OPureza:98%Cor e Forma:SolidPeso molecular:406.26
