Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2633 produtos de "Cromatina/Epigenética"
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Sirt2-IN-5
CAS:Sirt2-IN-5 is a potent inhibitor of SIRT2.Fórmula:C26H27Cl2N5O3Cor e Forma:SolidPeso molecular:528.43A1B11
CAS:A1B11 is a selective SIRT2 inhibitor.Fórmula:C22H25N5OCor e Forma:SolidPeso molecular:375.47(S,R)-CFT8634
CAS:(S,R)-CFT8634 is a selective and orally active BRD9 protein degrader with potential for researching BRD9-mediated disorders, such as abnormal cellularFórmula:C37H45F3N6O5Pureza:98%Cor e Forma:SolidPeso molecular:710.79INCB059872 tosylate
CAS:INCB059872: potent, selective oral LSD1 inhibitor, increasing tumor-suppressor gene expression by promoting H3K4 and H3K9 methylation.Fórmula:C37H50N2O9S2Cor e Forma:SolidPeso molecular:730.932HDAC/BET-IN-1
CAS:HDAC/BET-IN-1 inhibits HDAC1 (IC50: 0.163 μM), HDAC6 (IC50: 0.067 μM), BRD4 (Ki: 0.076 μM), and fights leukemia.Fórmula:C29H40N4O8SPureza:98%Cor e Forma:SolidPeso molecular:604.71GSK-2807 free base
CAS:GSK2807: potent, selective SMYD3 inhibitor (Ki=14 nM); targets SAM-binding site, potentially useful in cancer therapy.Fórmula:C19H32N8O5Cor e Forma:SolidPeso molecular:452.51PHD-IN-2
CAS:PHD-IN-2 (Compound 91), a potent PHD antagonist with an IC50 of less than 5 nM, effectively stimulates erythropoietin synthesis in HEP3B cells with an EC50 ofFórmula:C26H27N7O4Pureza:98%Cor e Forma:SolidPeso molecular:501.54(S)-Ro 32-0432
CAS:(S)-Ro 32-0432 is a potent, selective inhibitor of protein kinase C (PKC) and G protein-coupled receptor kinase 5 (GRK5), demonstrating ATP-competitive and oral activity. It presents IC50 values of 9.3 nM for PKCα, 28 nM for PKCβI, 30 nM for PKCβII, 36.5 nM for PKCγ, and 108.3 nM for PKCε, showcasing its effectiveness against multiple PKC isoforms. Additionally, (S)-Ro 32-0432 inhibits T-cell activation, indicating its potential application in the research of chronic inflammatory and autoimmune diseases [1] [2].Fórmula:C28H29ClN4O2Cor e Forma:SolidPeso molecular:489.011,2-Didecanoyl-sn-glycerol
CAS:GNN14490, a substrate for human pancreatic lipase, is utilized to create monomolecular films for enzyme assay studies.Fórmula:C23H44O5Cor e Forma:SolidPeso molecular:400.6FHT-1204
CAS:FHT-1204 is a potent inhibitor of SMARCA4/SMARCA2 ATPase (BRG1 and BRM) (IC50 ≤ 10 nM).Fórmula:C24H23N5O5S2Cor e Forma:SolidPeso molecular:525.6HDAC8-IN-4
CAS:HDAC8-IN-4 is a selective HDAC8 inhibitor, exhibiting inhibitory activity with IC50 values of 0.15 μM for HDAC8 and 12 μM for HDAC3 [1].Fórmula:C17H14N2O2S2Pureza:98%Cor e Forma:SolidPeso molecular:342.44HDAC-IN-38
CAS:HDAC-IN-38: Potent HDAC1-3,5,6,8 inhibitor, boosts H3K14/H4K5 acetylation, elevates CBF, lessens cognitive decline & hippocampal atrophy.Fórmula:C27H28ClN3O2Cor e Forma:SolidPeso molecular:461.98KT-531
CAS:KT-531 (KT531) is a highly potent and selective HDAC6 inhibitor with an IC50 value of 8.5 nM and is 39-fold more selective against other HDAC isoenzymes.Fórmula:C17H14F4N2O4SCor e Forma:SolidPeso molecular:418.36KDM2B-IN-1
CAS:KDM2B-IN-1: Potent, specific KDM2B histone demethylase inhibitor for hyperproliferative disease research.Fórmula:C21H30N4O2SCor e Forma:SolidPeso molecular:402.56HSP70/SIRT2-IN-2
CAS:HSP70/SIRT2-IN-2 (Compounds 1a), a dual inhibitor of SIRT2 and HSP70, exhibits an IC50 of 45.1±5.0 μM against SIRT2 and demonstrates antitumor activity [1].Fórmula:C17H13N3S3Pureza:98%Cor e Forma:SolidPeso molecular:355.5PIN1 inhibitor 2
CAS:PIN1 inhibitor 2, compound 12, impedes PIN1, shows promise in breast cancer study, and has IC50 of 9.55 μM in MCF7 cells.Fórmula:C16H21N3S2Cor e Forma:SolidPeso molecular:319.49CBB1007
CAS:CBB1007 is a potent, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Fórmula:C27H34N8O4Pureza:98%Cor e Forma:SolidPeso molecular:534.61F-Amidine TFA
CAS:F-amidine is a selective inhibitor of protein arginine deiminases (PADs), specifically targeting PAD1 and PAD4 with in vitro IC50 values of 29.5, 350, and 21.6 µM for PAD1, PAD3, and PAD4, respectively. It irreversibly inactivates all four PAD subtypes by covalently modifying an active site cysteine crucial for enzymatic activity, with kinact/KI values of 2,800, 380, 170, and 3,000 M^-1min^-1. Additionally, F-amidine demonstrates cytotoxicity against HL-60, MCF-7, and HT-29 cancer cell lines, with IC50s of 0.5, 0.5, and 1 μM, respectively.Fórmula:C14H19FN4O2CF3COOHCor e Forma:SolidPeso molecular:408.4CM-675
CAS:CM-675 is a dual inhibitor of phosphodiesterase 5 (PDE5) and class I histone deacetylases (IC50s: 114 nM and 673 nM for PDE5 and HDAC1) with the potential toFórmula:C31H32N6O3Pureza:99.82%Cor e Forma:SolidPeso molecular:536.62Ref: TM-T10841
1mg60,00€2mg90,00€5mg138,00€1mL*10mM (DMSO)152,00€10mg215,00€25mg358,00€50mg510,00€100mg692,00€JBI-589
CAS:JBI-589 is an isoform-selective, non-covalent inhibitor of PAD4 that diminishes CXCR2 expression and impedes neutrophil chemotaxis.Fórmula:C29H28FN5OCor e Forma:SolidPeso molecular:481.56
