Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2426 produtos de "Cromatina/Epigenética"
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Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Cor e Forma:SolidPeso molecular:587.54PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Fórmula:C41H42N10O6Pureza:98%Cor e Forma:SolidPeso molecular:770.84SJ988497
CAS:SJ988497: PROTAC JAK2 degrader, inhibits CRLF2r cell growth, degrades GSPT1, combines Ruxolitinib, linker, Pomalidomide; researched for ALL.Fórmula:C36H36N10O5Cor e Forma:SolidPeso molecular:688.74(S,R,S)-AHPC-C5-COOH
CAS:E3 ligase ligand-linker '(S,R,S)-AHPC-C5-COOH' for PROTACs, VH032 inhibits VHL/HIF-1α with 185 nM Kd, may aid anemia and ischemic disease research.Fórmula:C29H42N4O5SPureza:98%Cor e Forma:SolidPeso molecular:558.73PROTAC SMARCA2/4-degrader-25
PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06RMM23
RMM23 is an inhibitor that targets PfBDP1, exhibiting a Kd of 1.24 μM. In vitro, it shows EC50 values of 18 μM against the 3D7 wild-type strain, 14 μM against the NF54 wild-type strain, and 20 μM against the multidrug-resistant K1 strain during the blood stage.Cor e Forma:Odour SolidJAK-STAT Compound Library
<p>A unique collection of 252 JAK/STAT signaling targeted compounds for high throughput and high content screening;</p>Cor e Forma:Odour SolidPF-03622905
CAS:PF-03622905: potent ATP-competitive PKC inhibitor, IC50: 5.6-74.1 nM for PKCα/βI/βII/γ/θ, high specificity for PKC.Fórmula:C24H35N7O3Cor e Forma:SolidPeso molecular:469.59PROTAC BRD4 Degrader-5
CAS:PROTAC BRD4 Degrader-5 is a PROTAC that degrades BRD4 in HER2 positive and negative breast cancer cell lines.Fórmula:C50H62ClN9O8S2Cor e Forma:SolidPeso molecular:1016.67CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Fórmula:C27H37Cl3N8O4Pureza:98%Cor e Forma:SoildPeso molecular:643.99CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Fórmula:C25H22Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:557.45XF056-132
CAS:XF056-132 is a potent WDR5 (WD40 repeat domain protein 5) PROTAC degrader [1] .Fórmula:C51H57F4N9O7SCor e Forma:SolidPeso molecular:1016.11NCT-TFP
CAS:NCT-TFP is PARP probe used to identifying Poly(ADP-ribose) polymerases (PARP) inhibitors[1].Fórmula:C41H34F4N2O5Cor e Forma:SolidPeso molecular:710.71KAT6-IN-2
KAT6-IN-2 is a potent inhibitor of KAT6, showing promise for use in cancer research.Cor e Forma:Odour SolidDNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Cor e Forma:Odour SolidFTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417PROTAC SMARCA2/4-degrader-28
CAS:PROTAC SMARCA2/4-degrader-28 (PROTAC 1) functions as a partial degrader of SMARCA2 and SMARCA4 through the PROTAC-based mechanism.Fórmula:C54H68ClN9O11S2Cor e Forma:SolidPeso molecular:1118.75PROTAC BRD4 Degrader-27
CAS:PROTAC BRD4 Degrader-27 is a selective PROTAC targeting BRD4, distinguished from BRD2/BRD3. This compound is composed of the E3 ubiquitinase ligand Thalidomide-4-OH, the PROTAC Linker γ-Aminobutyric acid, and the PROTAC target protein ligand PROTAC BRD4 ligand-3. The active control for this target protein ligand is Mivebresib, while the conjugate of the E3 ubiquitin ligase ligand and Linker is identified as Pomalidomide 4'-alkylC3-acid.Fórmula:C37H30F2N6O7Cor e Forma:SolidPeso molecular:708.67Namoline
CAS:Namoline, a γ-pyrone, inhibits LSD1 with a 51 μM IC50, blocking cell growth and showing potential in prostate cancer studies.Fórmula:C10H3ClF3NO4Cor e Forma:SolidPeso molecular:293.58Axl-IN-16
Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptorFórmula:C14H19ClO8Pureza:98%Cor e Forma:SolidPeso molecular:350.75
