Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2437 produtos de "Cromatina/Epigenética"
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EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512PRMT5-IN-9
CAS:<p>PRMT5-IN-9 is a novel PRMT5 inhibitor for treating cancer, with an IC 50 of 0.01 μM.</p>Fórmula:C25H23F3N6OCor e Forma:SolidPeso molecular:480.495SIRT1-IN-1
CAS:<p>SIRT1-IN-1 is a selective inhibitor of SIRT1 with an IC50 of 205 nM.Cost-effective and quality-assured.</p>Fórmula:C14H16N2OPureza:99.58%Cor e Forma:SolidPeso molecular:228.29PROTAC SMARCA2/4 degrader-36
CAS:PROTACSMARCA2/4 degrader-36 (Compound 29) is a potent dual degrader targeting SMARCA2 and SMARCA4, exhibiting DC50 values of 0.22 nM and 0.85 nM, respectively. Additionally, PROTACSMARCA2/4 degrader-36 demonstrates antiproliferative activity.Fórmula:C53H62ClN9O4SCor e Forma:SolidPeso molecular:956.6357-Hydroxyneolamellarin A
CAS:7-Hydroxyneolamellarin A, from Dendrilla nigra, inhibits HIF-1α and VEGF in cancer research.Fórmula:C24H19NO5Cor e Forma:SolidPeso molecular:401.41Thalidomide-NH-CBP/p300 ligand 2
CAS:Thalidomide-NH-CBP/p300 ligand 2 (P-007) is a PROTAC-based compound designed to degrade CBP and p300, acting as a functional antagonist (WO2020173440).Fórmula:C48H57F2N11O6Cor e Forma:SolidPeso molecular:922.052PROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Fórmula:C46H53F2N11O6Cor e Forma:SolidPeso molecular:893.998BTR2004
BTR2004 is a selective PROTAC degrader targeting the BET family (BRD2/3/4) proteins. It facilitates the formation of a ternary complex with BRD proteins and KLHL20, leading to ubiquitination and proteasomal degradation via the UPS pathway. BTR2004 shows potential for research in PC3 prostate cancer and MDA-MB-231 breast cancer cell lines.Cor e Forma:Odour SolidEldocasiran
CAS:Eldocasiran, a micro-RNA-193a-3p analogue, exhibits anticancer properties. It is utilized in cancer research [1].Fórmula:C423H529N161O305P42Cor e Forma:SolidPeso molecular:14049.5Dihydrochlamydocin analog-1
CAS:Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.64GSK9311 hydrochloride
CAS:GSK9311 hydrochloride is a less active GSK6853 analog, serving as a negative control, inhibiting BRPF1/2 (pIC50: 6.0/4.3).Fórmula:C24H32ClN5O3Pureza:98%Cor e Forma:SolidPeso molecular:474XF067-68
CAS:XF067-68 is a PROTAC for targeted degradation of WD40 repeat domain protein 5 ( WDR5 )[1] .Fórmula:C52H59F4N9O7SCor e Forma:SolidPeso molecular:1030.14MAK-683 hydrochloride
CAS:MAK683 hydrochloride is an inhibitor of embryonic ectoderm development (EED), with IC50 values of 59, 26nM measured in EED Alphascreen, ELISA.Cost-effective and quality-assured.Fórmula:C20H18ClFN6OPureza:97.02% - >99.99%Cor e Forma:SolidPeso molecular:412.85CB1R/AMPK modulator 1
Compound 38-S is an orally active CB1R/AMPK modulator with a K i of 0.81 nM and an IC50 of 3.9 nM for CB1R.Fórmula:C25H22Cl2N6O3SPureza:98%Cor e Forma:SolidPeso molecular:557.45Pep2m, myristoylated
CAS:Myristoylated pep2m peptide; inhibits GluA2-NSF interaction, reducing AMPA receptor function and surface expression.Fórmula:C63H118N18O14SPureza:98%Cor e Forma:SolidPeso molecular:1383.8TNKS-2-IN-2
CAS:TNKS-2-IN-2 is a TNKS2 selective inhibitor (IC50: 22 nM) with potential anti-tumour activity for the study of colon cancer lung cancer and breast cancer.Fórmula:C26H23N3O6Pureza:99.45%Cor e Forma:SoildPeso molecular:473.48JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Fórmula:C43H45ClFN7O10SCor e Forma:SolidPeso molecular:906.375CBB1007 trihydrochloride (1379573-92-8 free base)
CAS:CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).Fórmula:C27H37Cl3N8O4Pureza:98%Cor e Forma:SoildPeso molecular:643.99PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2HDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Cor e Forma:Odour Solid
