Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2437 produtos de "Cromatina/Epigenética"
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CAS:PRMT1 inhibitor, IC50=1.8μM; 5x more selective than PRMT6; >250x over PRMT3, CARM1.Fórmula:C90H161ClN36O24Pureza:98%Cor e Forma:SolidPeso molecular:2166.94FTX-6058
CAS:FTX-6058 is an oral inhibitor of EED that induces HbF and may treat hemoglobinopathies like sickle cell and β-thalassemia.Fórmula:C22H18FN5O2Cor e Forma:SolidPeso molecular:403.417Mersalyl
CAS:Mersalyl is an organic mercurial diuretic.Fórmula:C13H16HgNNaO6Cor e Forma:SolidPeso molecular:505.854PROTAC SMARCA2/4-degrader-25
PROTAC SMARCA2/4-degrader-25 is a PROTAC that targets SMARCA2/4. It consists of the E3 ligase ligand (2S,4R)-4-Hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, a PROTAC Linker (S)-2-Amino-3,3-dimethylbutanoic acid, and the target protein ligand SMARCA2/4-ligand-3. The conjugate of the E3 ubiquitin ligase ligand and Linker is (S,R,S)-AHPC.Fórmula:C44H50N10O9S2Cor e Forma:SolidPeso molecular:927.06Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Fórmula:C26H31FN7O6PPureza:99.92% - 99.97%Cor e Forma:SolidPeso molecular:587.54PROTAC BRD2/BRD4 degrader-1
Compound 15: Potent PROTAC, selectively degrades BRD4/BRD2, has low toxicity, and is built of a BET inhibitor, linker, and CRBN ligand.Fórmula:C39H38N6O9SPureza:98%Cor e Forma:SolidPeso molecular:766.82Larsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SoildPeso molecular:499.75SIM1
SIM1, a potent PROTAC®Degrader, preferentially degrades BET proteins (BRD4, BRD2, BRD3) and induces apoptosis in prostate cancer cells.Cor e Forma:LiquidCW-3308
<p>CW-3308 is an orally active PROTAC that targets BRD9. It is composed of the PROTAC target protein ligand Naphthyridin-Me-dimethoxybenzene-COOH, the linker 3-Azaspiro[5.5]undecane-9-methanol, and the E3 ubiquitin ligase ligand Thalidomide-methylpyrrolidine. The coupling of the E3 ubiquitin ligase ligand with the linker results in the conjugate Thalidomide-pyrrolidine-C-azaspiro.</p>Fórmula:C45H48N6O8Cor e Forma:SolidPeso molecular:800.9GSK040
CAS:GSK040: Potent BET BD2 inhibitor, pIC50 8.3, 5000x selectivity over BD1, for oncology & immunology research.Fórmula:C29H34N4O4Cor e Forma:SolidPeso molecular:502.6Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg
CAS:Lys-arg-ala-lys-ala-lys-thr-thr-lys-lys-arg is a protein kinase C substrate.Fórmula:C56H110N22O14Pureza:98%Cor e Forma:SolidPeso molecular:1315.61SW2_110A acetate
SW2_110A acetate is a selective, cell-permeable chromobox inhibitor of homologue CBX8 (Kd = 800 nM) bound to CBX8 N-terminal color gamut (ChD).Fórmula:C44H64N6O9Pureza:98%Cor e Forma:SoildPeso molecular:821.01Fluorescein-NAD+
Fluorescein NAD+ is a non-radioactive PARP assay substrate, enabling direct enzyme measurement by fluorescence. Comes as 81μg in 250μl water.Cor e Forma:SolidZIP
CAS:Novel inhibitor for PKMζ, halts synaptic potentiation and reverses LTP with IC50 of 1-2.5 μM, erasing spatial memory.Fórmula:C90H154N30O17Pureza:98%Cor e Forma:SolidPeso molecular:1928.4FTX-6058 hydrochloride
CAS:FTX-6058 hydrochloride is a potent EED inhibitor, induces HbF, and aids sickle cell and β-thalassemia research.Fórmula:C22H19ClFN5O2Cor e Forma:SolidPeso molecular:439.87Foenumoside B
CAS:Foenumoside B, a triterpene saponin extracted from Lysimachia foenum-graecum, stimulates AMPK signaling, suppresses PPARγ-induced adipogenesis, and promotesFórmula:C60H96O25Pureza:98%Cor e Forma:SolidPeso molecular:1217.39HDAC6 degrader-3
CAS:HDAC6 degrader-3: potent, selective, degrades HDAC6 at 19.4 nM, weakens HDAC1 at 0.647 μM, induces α-tubulin hyperacetylation.Fórmula:C41H41F4N7O11Cor e Forma:SolidPeso molecular:883.8HD-TAC7
CAS:HD-TAC7 is a PROTAC HDAC degrader; IC50s: HDAC1 (3.6μM), HDAC2 (4.2μM), HDAC3 (1.1μM); reduces NF-κB p65; researched for asthma, COPD.Fórmula:C33H32FN7O7Cor e Forma:SolidPeso molecular:657.65BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67PROTAC CBP/P300 Degrader-1
CAS:PROTAC CBP/P300 Degrader-1 effectively reduces cancer cell viability by degrading CBP/P300.Fórmula:C46H53F2N11O6Cor e Forma:SolidPeso molecular:893.998
