Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2437 produtos de "Cromatina/Epigenética"
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Ep300/CREBBP-IN-4
CAS:Ep300/CREBBP-IN-4, an Ep300 & CREBBP inhibitor; IC50: 0.024μM & 0.064μM. For cancer research.Fórmula:C23H22F3N5O3Cor e Forma:SolidPeso molecular:473.45PROTAC BRD4 Degrader-14
PROTAC BRD4 Degrader-14 binds VHL & BRD4, degrades BRD4 in PC3 cells; IC50: 1.8/1.7 nM BD1/BD2.Fórmula:C57H61F2N9O11S2Cor e Forma:SolidPeso molecular:1150.27MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67SIRT5 inhibitor 8
CAS:SIRT5 inhibitor 8 (compound 10) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=5.38 μM, with potential anticancer effects.Fórmula:C22H25ClN8O2SPureza:99.56%Cor e Forma:SolidPeso molecular:501XY-06-007
CAS:XY-06-007: Selective PROTAC BRD4 BD1 L94V degrader with 10 nM DC50, 6h & clean off-target profile; good for in vivo studies.Fórmula:C41H41ClN8O8Cor e Forma:SolidPeso molecular:809.27GSK3735967
CAS:GSK3735967: DNMT1 inhibitor, IC50 40 nM, dicyanopyridine core, binds hemimethylated CpG, interacts with H4K20me3.Fórmula:C25H31N7OSCor e Forma:SolidPeso molecular:477.62PROTAC BRD4 Degrader-13
CAS:PROTAC BRD4 Degrader-13 targets VHL and BRD4, degrading BRD4 with DC50 of 0.025/6.0 nM in PC3 cells when linked to STEAP1/CLL1 antibodies.Fórmula:C68H85F2N11O17P2S2Cor e Forma:SolidPeso molecular:1492.55SGC3027
<p>SGC3027 is an inhibitor of histone methyltransferase,also is a first potent, selective and cell active chemical probe for PRMT7.</p>Fórmula:C41H47ClN6O6SPureza:98%Cor e Forma:SolidPeso molecular:787.37FKBP12 PROTAC dTAG-7
CAS:dTAG-7 selectively degrades BRD4 and FKBP12F36V by linking BET bromodomains to E3 ligase CRBN; it's a heterobifunctional degrader.Fórmula:C63H79N5O19Pureza:98%Cor e Forma:SolidPeso molecular:1210.32N-Desmethyltamoxifen
CAS:N-Desmethyltamoxifen, tamoxifen's main human metabolite, regulates AML cell ceramide metabolism and is a more potent PKC inhibitor than tamoxifen.Fórmula:C25H27NOPureza:98%Cor e Forma:SolidPeso molecular:357.49PROTAC BET Degrader-10
CAS:PROTAC BET Degrader-10 targets and degrades BRD4 with a DC50 of 49 nM, using Cereblon ligands.Fórmula:C39H39ClN8O6SCor e Forma:SolidPeso molecular:783.3DAO-dBET1
DAO-dBET1, a dual-action PROTAC incorporating the PROTAC degrader dBET1, effectively serves as a potent BRD4 degrader and exhibits a DC50 value of 277 nM in the presence of CoCl2. Additionally, DAO-dBET1 inhibits hypoxia and Cath-L activation with an IC50 value of 281 nM.Cor e Forma:Odour SolidSIRT5 inhibitor 9
CAS:SIRT5 inhibitor 9 (compound 14) is a moderately selective and substrate-competitive SIRT5 inhibitor with IC50=4.07 μM and has potential anticancer effects.Fórmula:C24H29ClN8O4SPureza:98.68%Cor e Forma:SolidPeso molecular:561.06MS049 2HCl (1502816-23-0(free base))
MS049 inhibits PRMT4 (IC50=34nM) & PRMT6 (IC50=43nM), less so for PRMT1, PRMT3, PRMT8, not others.Fórmula:C15H26Cl2N2OPureza:99.9%Cor e Forma:SolidPeso molecular:321.28PKC β pseudosubstrate
CAS:Selective cell-permeable peptide inhibitor of protein kinase C (IC50 ~ 0.5 μM).Fórmula:C177H294N62O38S3Pureza:98%Cor e Forma:SolidPeso molecular:3994.84FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Cor e Forma:LiquidPROTAC HDAC6 degrader 3
PROTACHDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader of HDAC6, with an IC50 of 686 nM and a DC50 of 171 nM. It enhances the acetylation of α-tubulin. [Pink: ligand for target protein; Blue: ligand for E3ligaseVHL.]Fórmula:C46H56F2N10O9SCor e Forma:SolidPeso molecular:963.06Okicenone
CAS:<p>Okicenone is an antibiotic, interferring with HuR RNA binding, HuR trafficking, T-cell activation and cytokine expression.</p>Fórmula:C15H14O4Cor e Forma:SolidPeso molecular:258.27KB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Fórmula:C38H43Cl2N7O6SPureza:98%Cor e Forma:SoildPeso molecular:796.76Echinomycin
CAS:Echinomycin (Quinomycin A) is a quinoxaline antibiotic and a DNA-intercalating peptide that inhibits hypoxia-inducible factor-1 (HIF-1) DNA binding activity.Fórmula:C51H64N12O12S2Pureza:95%Cor e Forma:SolidPeso molecular:1101.26
