Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2599 produtos para "Cromatina/Epigenética".
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JAK1/TYK2-IN-1
CAS:JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 ( IC 50 = 29 and 41 nM respectively).Fórmula:C18H20F3N7OCor e Forma:SolidPeso molecular:407.401BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFórmula:C17H18N2O3SPureza:99.97%Cor e Forma:SolidPeso molecular:330.4Dihydrochlamydocin analog-1
CAS:Dihydrochlamydocinanalog-1 (compound 2) is a Chlamydocin analog that inhibits the deacetylation of histone H4 peptides, with an IC50 of 30 nM.Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.64PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2M-808
CAS:M-808, a strong covalent Menin-MLL inhibitor, binds tightly with a 2.6 nM IC50.Fórmula:C45H63FN6O5SCor e Forma:SolidPeso molecular:819.09EEDi-5273
CAS:EEDi-5273: Potent oral EED inhibitor, IC50 ~0.2 nM; induces complete, lasting tumor regression.Fórmula:C26H22F4N6O2Cor e Forma:SolidPeso molecular:526.496EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512EXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35CPI-268456
CAS:CPI-268456 is a compound which has bioactive.Fórmula:C20H15Cl2N3O2Cor e Forma:SolidPeso molecular:400.26HDAC6-IN-54
HDAC6-IN-54 (Compound 9m) is a highly selective inhibitor of HDAC6 (histone deacetylase 6), with an IC50 value of 0.021 μM. It prevents the activation of the NLRP3 inflammasome, providing relief from symptoms associated with NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis.BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Cor e Forma:SolidMZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Cor e Forma:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarCDD-1102 HCl
CDD-1102 HCl is a novel BRDT-BD4 / BRD2-BD1302 selective inhibitor that shows non-hormonal contraceptive potential in ex vivo experiments.Fórmula:C32H31ClN6O3Pureza:98.30%Cor e Forma:SoildPeso molecular:583.08JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.Fórmula:C43H51ClN8O3S2Cor e Forma:SolidPeso molecular:827.5WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Fórmula:C61H72N10O10S2Cor e Forma:SolidPeso molecular:1169.42HDAC6-IN-53
HDAC6-IN-53 (Compound W28) is an inhibitor targeting histone deacetylase 6 (HDAC6) with an IC50 of 19.65 nM. It reduces the idiopathic pulmonary fibrosis (IPF) phenotype by inhibiting TGF-β1-induced collagen expression and demonstrates therapeutic efficacy in a bleomycin-induced mouse model of pulmonary fibrosis. HDAC6-IN-53 is applicable for research in idiopathic pulmonary fibrosis and related pulmonary fibrotic diseases.Cor e Forma:Odour Solid
