Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2677 produtos para "Cromatina/Epigenética".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
MS33
CAS:MS33 degrades WDR5 protein, Kd 870 nM (VCB), 120 nM (WDR5); uses VHL ligase, aids acute myeloid leukemia study.Fórmula:C64H84F3N11O7SCor e Forma:SolidPeso molecular:1208.5JAK2-IN-10
CAS:JAK2-IN-10 is a potent inhibitor of JAK2v617f, with an IC50 value of ≤10 nM.Fórmula:C33H33D3FN9O2Cor e Forma:SolidPeso molecular:612.71Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Cor e Forma:Odour SolidRef: TM-L1600
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarEXQ-2d
EXQ-2d is an inhibitor of tankyrase, effectively targeting TNKS1 and TNKS2 with IC50 values of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86), respectively. Additionally, EXQ-2d suppresses the WNT/β-catenin signaling pathway with an IC50 of 515 nM. It demonstrates antiproliferative activity in cancer cells COLO 320DM and RKO, with GI50 values of 4.9 μM and 77 μM, respectively.Fórmula:C18H17N3O3Cor e Forma:SolidPeso molecular:323.35PROTAC BET degrader-2
CAS:PROTAC BET degrader-2 is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins (IC50 of 9.6 nM ).Fórmula:C41H42N10O6Pureza:98%Cor e Forma:SolidPeso molecular:770.84Ref: TM-T12559
50mgA consultar100mgA consultar5mg359,00€10mg567,00€1mL*10mM (DMSO)573,00€25mg1.054,00€HDAC6-IN-54
HDAC6-IN-54 (Compound 9m) is a highly selective inhibitor of HDAC6 (histone deacetylase 6), with an IC50 value of 0.021 μM. It prevents the activation of the NLRP3 inflammasome, providing relief from symptoms associated with NLRP3 inflammasome-related diseases such as acute peritonitis, inflammatory bowel disease, and psoriasis.SJ1008030 formic
SJ1008030 (compound 8) formic is a selective JAK2 degrader within the PROTAC class, demonstrating efficacy in inhibiting MHH-CALL-4 leukemia cell growth with anFórmula:C43H45N13O9SPureza:98%Cor e Forma:SolidPeso molecular:919.96BRD4-IN-4
CAS:BRD4-IN-4 is a selective BRD4 inhibitor with an IC50 value of 6.83 μM for BRD4.BRD4-IN-4 selectively inhibits the proliferation of the MV4-11 cell line andFórmula:C17H18N2O3SPureza:99.97%Cor e Forma:SolidPeso molecular:330.4BRD4 degrader-6
CAS:BRD4 degrader-6 is a dimeric BDR4PROTAC class degrader with a DC50 of less than 0.1 μM. It effectively induces the ubiquitination and degradation of BDR4, exhibiting anticancer properties.Fórmula:C61H71BClN9O7S2Cor e Forma:SolidPeso molecular:1152.67UNC4976
UNC4976 is a positive allosteric modulator (PAM) peptidomimetic of CBX7 chromodomain binding to nucleic acids.Fórmula:C47H70N6O8Pureza:98%Cor e Forma:SolidPeso molecular:847.09HDAC/CD13-IN-1
HDAC/CD13-IN-1 (Compound 12) is an inhibitor of both HDAC and CD13, with IC50 values of 0.34 μM for hCD13, 0.53 μM for porcine CD13, and 0.03, 0.06, and 0.02 μMFórmula:C27H41Cl2N5O4Pureza:98%Cor e Forma:SolidPeso molecular:570.55SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Fórmula:C41H46N12O5SCor e Forma:SolidPeso molecular:818.95JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid)-NH-C2-NH-AMPRO-222 incorporates a BRD4 ligand and a PROTAC linker, and is used in the synthesis of PROTAC BRD4 Degrader-29.Fórmula:C43H51ClN8O3S2Cor e Forma:SolidPeso molecular:827.5WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Cor e Forma:SolidPeso molecular:556.576MZP-54
CAS:MZP-54 is a selective degrader of BRD3/4 based on PROTAC technology(Kd of 4 nM for Brd4BD2)Fórmula:C55H66ClN7O9SPureza:98%Cor e Forma:SolidPeso molecular:1036.67UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68Dihydrochlamydocin
CAS:Dihydrochlamydocin, an inhibitor of histone deacetylases (HDAC), exhibits potent cytostatic activity against mastocytoma cells.Fórmula:C28H40N4O6Cor e Forma:SolidPeso molecular:528.65QA-68
QA-68 is a potent BRD9 degrader, inhibits cell growth, and has anti-leukemic properties.Fórmula:C61H72N10O10S2Cor e Forma:SolidPeso molecular:1169.42KB02-JQ1
CAS:KB02-JQ1: potent BRD4-degrading PROTAC, stable, specific; doesn't affect BRD2/3, modifies DCAF16 for action.Fórmula:C38H43Cl2N7O6SPureza:98%Cor e Forma:SolidPeso molecular:796.77BETd-246
CAS:BETd-246 is an inhibitor of second-generation and PROTAC-based BET bromodomain (BRD), show antitumor activity.Fórmula:C48H55N11O10Pureza:98%Cor e Forma:SolidPeso molecular:946.02
