Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2441 produtos de "Cromatina/Epigenética"
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I-BET567
CAS:I-BET567: potent, oral pan-BET inhibitor; pIC50s: 6.9 (BRD4 BD1), 7.2 (BD2); effective in mouse cancer and inflammation models.Fórmula:C17H18ClN5O2Pureza:99.8%Cor e Forma:SolidPeso molecular:359.81Ref: TM-T9619
1mg94,00€5mg197,00€10mg303,00€25mg607,00€50mg912,00€100mg1.339,00€1mL*10mM (DMSO)216,00€T-448
CAS:T-448 is a lysine-specific demethylase 1 inhibitor (IC50: 22 nM) that improves learning function in mice.T-448 can be used to study memory deficits.Fórmula:C19H22N4O3SPureza:97% - 98.63%Cor e Forma:SolidPeso molecular:386.47Eicosapentaenoic Acid (Standard)
CAS:Eicosapentaenoic Acid (Standard) is the standard substance of Eicosapentaenoic Acid, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Eicosapentaenoic Acid is an ω-3 fatty acid and an inhibitor of fatty acid synthase (FASN). Eicosapentaenoic Acid promotes DNA demethylation in the reexpression of the tumor suppressor gene CCAAT/ enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid activates the RAS/ERK/C/EBPβ pathway in U937 leukemia cells through demethylation of the CpG island of H-RAS intron 1. Eicosapentaenoic Acid promotes the relaxation of vascular smooth muscle cells and vasodilation.Fórmula:C20H30O2Peso molecular:302.45Boc-Lys(Ac)-AMC
CAS:Boc-Lys(Ac)-AMC (Boc-L-Lys(Ac)-AMC) is a synthetic substrate coupled to an HDAC-specific fluorophore (Ex/Em = 355 nm/460 nm).Fórmula:C23H31N3O6Pureza:99.87%Cor e Forma:SolidPeso molecular:445.51Ref: TM-T36578
5mg49,00€10mg80,00€25mg136,00€50mg192,00€100mg283,00€200mg409,00€1mL*10mM (DMSO)54,00€KDM4-IN-3
CAS:KDM4-IN-3 is a KDM4 inhibitor that is cell-permeable and kills prostate cancer cells at low micromolar concentrations.Fórmula:C17H14N4OCor e Forma:SolidPeso molecular:290.32PROTAC PARP1 degrader
CAS:PROTAC PARP1 degrader suppresses MDA-MB-231 cells at 10 μM, IC50: 6.12 μM in 24h.Fórmula:C58H63Cl2N11O10Pureza:98%Cor e Forma:SolidPeso molecular:1145.1GSK9311
CAS:GSK9311 inhibits BRPF bromodomain (pIC50: 6.0 and 4.3 for BRPF1 and BRPF2, respectively).Fórmula:C24H31N5O3Pureza:98%Cor e Forma:SolidPeso molecular:437.53JET-209
JET-209 is a potent proteolysis-targeting chimera (PROTAC) that effectively degrades CBP/p300, exhibiting half-maximal degradation concentration (DC50) valuesFórmula:C46H47N9O6Pureza:98%Cor e Forma:SolidPeso molecular:821.92(±)-1,2-Diolein
CAS:(±)-1,2-Diolein (1,2-Dioleoyl-rac-glycerol) (1,2-Dioleoyl-rac-glycerol) is a PKC activator. (±)-1,2-Diolein could increases myotubes Ca 2+ influx.Fórmula:C39H72O5Cor e Forma:SolidPeso molecular:620.99Atinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Fórmula:C16H17FN6O3Pureza:99.36%Cor e Forma:SolidPeso molecular:360.35Ref: TM-T39646
1mg145,00€5mg354,00€10mg582,00€25mg1.121,00€50mg1.833,00€100mg2.688,00€1mL*10mM (DMSO)279,00€Pim-1/2 kinase inhibitor 1
CAS:Orally active Pim-1/2 inhibitor blocks kinase phosphorylation; used in prostate cancer research.Fórmula:C11H9NO3SPureza:99.78%Cor e Forma:SolidPeso molecular:235.26N-Descyclopropanecarbaldehyde Olaparib
CAS:N-Descyclopropanecarbaldehyde Olaparib is a CRBN ligand for dual EGFR/PARP PROTAC, suitable for F-18 radiolabeling and tumor imaging via PET.Fórmula:C20H19FN4O2Cor e Forma:SolidPeso molecular:366.392'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Fórmula:C9H13ClFN3O4Pureza:99.43%Cor e Forma:SolidPeso molecular:281.67INO-1001
CAS:INO-1001: potent PARP inhibitor with antitumor properties, enhances radiosensitivity & radiation-induced cell death.Fórmula:C23H25N3O4SCor e Forma:SolidPeso molecular:439.53Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Fórmula:C17H17N7O2SPureza:99.88%Cor e Forma:SolidPeso molecular:383.43Ref: TM-T38571
1mg97,00€5mg243,00€10mg376,00€25mg753,00€50mg1.254,00€100mg1.890,00€200mg2.547,00€1mL*10mM (DMSO)265,00€SIRT-IN-3
CAS:SIRT-IN-3: potent SIRT1 inhibitor (IC50=17μM), 4x selective over SIRT2, 14x over SIRT3 (IC50s: 74μM & 235μM).Fórmula:C13H12N2OCor e Forma:SolidPeso molecular:212.25ADTL-SA1215
CAS:ADTL-SA1215 is a SIRT3 activator with SIRT3 deacetylase activity for the study of triple negative breast cancer.Fórmula:C26H29I2NO3Pureza:99.23%Cor e Forma:SolidPeso molecular:657.32MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Cor e Forma:SolidPeso molecular:532.12GSK-J2
CAS:GSK-J2 is an inactive enantiomer of GSK-J1 that is lipophilic and serves as an inactive control for GSK-J21.Fórmula:C22H23N5O2Pureza:97.55%Cor e Forma:SolidPeso molecular:389.45Ref: TM-T11476
1mg35,00€5mg74,00€10mg97,00€25mg165,00€50mg235,00€100mg346,00€200mg515,00€1mL*10mM (DMSO)106,00€CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Fórmula:C22H19F2N5O2Pureza:99.38%Cor e Forma:SolidPeso molecular:423.42
