Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2437 produtos de "Cromatina/Epigenética"
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MK-5108
CAS:MK-5108 (VX-689) is a highly potent and specific Aurora-A kinase inhibitor with an IC50 value of 0.064 nM.Fórmula:C22H21ClFN3O3SPureza:99.22%Cor e Forma:SolidPeso molecular:461.94GSK2807 Trifluoroacetate
CAS:GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Fórmula:C21H33F3N8O7Pureza:99.95%Cor e Forma:SolidPeso molecular:566.53Acedapsone
CAS:Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.Fórmula:C16H16N2O4SPureza:98%Cor e Forma:SolidPeso molecular:332.372-PADQZ
CAS:DPQ is an antiviral compound.Fórmula:C14H19N5O2Pureza:98%Cor e Forma:White PowderPeso molecular:289.33Diethyl bipy55'DC
CAS:<p>"Diethyl bipy55'DC blocks CP4H, crucial for collagen stability via hydroxylation in cells."</p>Fórmula:C16H16N2O4Pureza:98%Cor e Forma:SolidPeso molecular:300.31TETi76
CAS:TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Fórmula:C10H16O5Cor e Forma:SolidPeso molecular:216.23(R)-Dihydrolipoic acid
CAS:(R)-Dihydrolipoic acid, the biochemically significant R-enantiomer, partakes in biochemical transformations.Fórmula:C8H16O2S2Pureza:98%Cor e Forma:SolidPeso molecular:208.33Tazemetostat trihydrochloride
CAS:Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Fórmula:C34H47Cl3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:682.12Nicotinamide-d4
CAS:Nicotinamide-d4 is a deuterium-labelled compound of nicotinamide for isotope tracing. Nicotinamide, a vitamin B3 derivative, inhibits SIRT1 and SIRT2.Fórmula:C6H2D4N2OPureza:99.746%Cor e Forma:SolidPeso molecular:126.15GSK 4027
CAS:GSK 4027 is a PCAF/GCN5 bromodomain chemical probe. In a time-resolved fluorescence resonance energy transfer (TR-FRET) assay, it has a pIC50 of 7.4±0.11 for PCAF.Fórmula:C17H21BrN4OCor e Forma:SolidPeso molecular:377.28193 D7
CAS:<p>193 D7 is an inhibitor of histone demethylase JMJD1C (IC50= 0.59 μM in in vitro demethylation assay). In vivo, 193 D7 suppresses tumors by targeting intratumoral Treg cells in mouse tumor models.</p>Fórmula:C16H15NO4SCor e Forma:SolidPeso molecular:317.36AdipoR agonist 1
CAS:AdipoR agonist 1 (Compound 112254), acting as an agonist for the adiponectin receptor (AdipoR), stimulates transcriptional regulators including peroxisome proliferator-activated receptors (PPARs), peroxisome proliferator-activated receptor gamma coactivator 1α (PGC-1α), sirtuin 1 (SIRT1), and adenylate-activated protein kinase (AMPK). It is employed in the field of preventive doping research.Fórmula:C26H35N3O3Cor e Forma:SolidPeso molecular:437.57KR-39038
CAS:KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Fórmula:C24H32ClFN6OCor e Forma:SolidPeso molecular:475.00Guanosine-5'-triphosphate disodium salt
CAS:5'-GTP disodium salt boosts myogenic differentiation and fuels cellular processes.Fórmula:C10H14N5Na2O14P3Pureza:95.69% - 99.96%Cor e Forma:Odorless White SolidPeso molecular:567.14ZM39923
CAS:ZM39923 is a JAK3 inhibitor (pIC50: 7.1). ZM39923 also effectively inhibits tissue transglutaminase (IC50: 10 nM).Fórmula:C23H25NOPureza:98%Cor e Forma:SolidPeso molecular:331.45Asteltoxin
CAS:Asteltoxin is a useful organic compound for research related to life sciences. The catalog number is T124203 and the CAS number is 79663-49-3.Fórmula:C23H30O7Cor e Forma:SolidPeso molecular:418.486BG48
CAS:BG48, a COMET probe, enables precise optical epigenetic control and photochromically blocks human histone deacetylases with visible light.Fórmula:C25H23N5OSCor e Forma:SolidPeso molecular:441.55HDAC6-IN-27
CAS:HDAC6-IN-27 (compound 8C), an HDAC inhibitor, exhibits IC 50 values of 15.9 nM, 136.5 nM, and 6180.2 nM against HDAC6, HDAC8, and HDAC1, respectively. It also demonstrates potent antiparasitic effects [1].Fórmula:C15H15N3O4Cor e Forma:SolidPeso molecular:301.3I-BET787
CAS:I-BET787, an orally active pan-BET bromodomain inhibitor, has demonstrated efficacy in murine inflammation models.Fórmula:C16H20ClN3O2Cor e Forma:SolidPeso molecular:321.80(3S,4S)-Tofacitinib
CAS:(3S,4S)-Tofacitinib, a less active enantiomer of tofacitinib, is a Janus kinases inhibitor.Fórmula:C16H20N6OPureza:98%Cor e Forma:SolidPeso molecular:312.37
