Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2553 produtos de "Cromatina/Epigenética"
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A2B57
CAS:A2B57 is a selective SIRT2 inhibitor.Fórmula:C22H19N5OPureza:98%Cor e Forma:SolidPeso molecular:369.42A2AAR/HDAC-IN-1
CAS:A2AAR/HDAC-IN-1 (compound 14c) is an orally active, balanced A2AAR/HDAC dual inhibitor of A2AAR (Ki: 163.5 nM), HDAC1 (IC50: 145.3 nM). effect.Fórmula:C24H21N7O2Cor e Forma:SolidPeso molecular:439.47MARK-IN-4
CAS:MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Fórmula:C21H23N7OSCor e Forma:SolidPeso molecular:421.52PARP1-IN-9
CAS:PARP1-IN-9, potent PARP1 inhibitor with 30.51 nM IC50, outperforms Olaparib in anticancer efficacy.Fórmula:C18H21N3O5Cor e Forma:SolidPeso molecular:359.38NCDM-32B
CAS:NCDM-32B, a novel potent and selective KDM4 inhibitor, impairs viability and transforms phenotypes of basal breast cancer.Fórmula:C15H30N2O4Pureza:98%Cor e Forma:SolidPeso molecular:302.41aPKC-I
CAS:aPKC-I specifically inhibits PKCζ/i, blocks VEGF effects, and prevents IR-induced permeability in cells and live models.Fórmula:C15H17NO4SCor e Forma:SolidPeso molecular:307.36NAT2-IN-1
CAS:NAT2-IN-1 (APA) is a selective inhibitor of the drug metabolism enzyme N-acetyltransferase 2 (NAT2), capable of targeting and eliminating cells with slow NAT2Fórmula:C19H20N4O3Cor e Forma:SolidPeso molecular:352.39SC-10
CAS:SC-10 is a direct activator of PKC with potential antiproliferative activity, useful in leukemia research.Fórmula:C17H22ClNO2SPureza:99.24% - 99.58%Cor e Forma:SolidPeso molecular:339.88Tinostamustine HCl
CAS:Tinostamustine (EDO-S101) is an alkylating HDACi fusion molecule, enhancing potency and overcoming drug resistance.Fórmula:C19H29Cl3N4O2Cor e Forma:SolidPeso molecular:451.82CAY10721
CAS:CAY10721 inhibits SIRT3 (39% at 200 μM), linked to OSCC and breast cancer; lowers OSCC growth, enhances radio/chemo sensitivity.Fórmula:C18H13N3O3SCor e Forma:SolidPeso molecular:351.38MAT2A-IN-6
CAS:MAT2A-IN-6 inhibits MAT2A, may slow MTAP-deficient cancer cell growth, has research value in cancer.Fórmula:C18H13ClF3N3O3Cor e Forma:SolidPeso molecular:411.76CSV0C018875 Hydrochloride
CAS:CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Fórmula:C18H18Cl2N2OCor e Forma:SolidPeso molecular:349.255MZ-242
CAS:MZ-242 is an effective and selective inhibitor of Sirt2.Fórmula:C24H27N7O3S2Pureza:98%Cor e Forma:SolidPeso molecular:525.65KDOAM-25
CAS:KDOAM-25, a potent KDM5 inhibitor, enhances H3K4 methylation, hampers MM1S cell growth; IC50: 71 nM (5A), 19 nM (5B), 69 nM (5C/D).Fórmula:C15H25N5O2Pureza:98%Cor e Forma:SolidPeso molecular:307.39HMS607P03
CAS:HMS607P03 is an activator of SIRT1 which induces autophagic cell death via the AMPK-mTOR-ULK complex and induces mitophagy by the SIRT1-PINK1-Parkin pathway.Fórmula:C26H19ClN4O3S2Cor e Forma:SolidPeso molecular:535.045-Octyl-α-ketoglutarate
CAS:In addition to its role in the Krebs cycle, α-ketoglutarate (2-oxoglutarate) has roles as a substrate or modulator of enzymes.Fórmula:C13H22O5Cor e Forma:SolidPeso molecular:258.31Aurora Kinases-IN-2
CAS:Aurora Kinases-IN-2 (12Aj) hinders Aurora A/B kinases (IC50: 90/152 nM), used in cancer studies.Fórmula:C22H18ClN5O3Cor e Forma:SolidPeso molecular:435.86CypD inhibitor C-9
CAS:CypD inhibitor C-9 is a CypD inhibitor, it attenuates mitochondrial and cellular perturbation insulted by Aß and calcium stress.Fórmula:C22H22N4O4S2Cor e Forma:SolidPeso molecular:470.564-iodo-SAHA
CAS:4-Iodo-SAHA (1k), an oral HDAC inhibitor for cancer research, has EC50s from 0.12 to 1.3 μM across various cell lines.Fórmula:C14H19IN2O3Cor e Forma:SolidPeso molecular:390.22Bizine dihydrochloride
CAS:Bizine dihydrochloride is a potent LSD1 inhibitor in vitro, being selective versus monoamine oxidases A/B and the LSD1 homologue, LSD2.Fórmula:C18H25Cl2N3OCor e Forma:SolidPeso molecular:370.32
