Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2566 produtos de "Cromatina/Epigenética"
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JAK-IN-18
CAS:"JAK-IN-18: potent JAK inhibitor for eye, skin, respiratory disease research (WO2018204238A1, comp 1)."Fórmula:C27H28F2N6O3Cor e Forma:SolidPeso molecular:522.55ST7710AA1
CAS:ST7710AA1 inhibits PARP-1, effectively targets in vitro, and overcomes Pgp-associated multidrug resistance.Fórmula:C20H22N4OCor e Forma:SolidPeso molecular:334.41NCGC00247743
CAS:NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.Fórmula:C24H29N3O2Pureza:98%Cor e Forma:SolidPeso molecular:391.51NR-160
CAS:NR-160 is a selective HDAC6 inhibitor (IC50=0.03μM), weaker on HDAC1-4,8, toxic to 7 cancer lines, boosts bortezomib and anthracycline effects.Fórmula:C25H21F3N6O3Cor e Forma:SolidPeso molecular:510.47Aurora A/PKC-IN-1
CAS:Aurora A/PKC-IN-1 inhibits AurA (IC50: 6.9 nM), PKCα (IC50: 16.9 nM), and hinders breast cancer cell growth and spread.Fórmula:C16H14N6OSe2Cor e Forma:SolidPeso molecular:464.24NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24BPTF-IN-1
CAS:BPTF-IN-1 (AU1), a BPTF bromodomain inhibitor with 2.8 μM affinity, shows higher selectivity over BRD4 and possesses antimalarial properties.Fórmula:C23H23FN6O3Cor e Forma:SolidPeso molecular:450.47CPI-4203
CAS:CPI-4203 is a selective inhibitor of KDM5 demethylases.Fórmula:C16H14N4OCor e Forma:SolidPeso molecular:278.31Acefylline piperazine
CAS:Acefylline piperazine, a less toxic theophylline derivative, treats asthma and bronchitis by bronchodilation, stimulating respiration and CNS.Fórmula:C9H10N4O4·xC4H10N2Cor e Forma:SolidPeso molecular:562.54KDM2B-IN-3
CAS:KDM2B-IN-3, from patent WO2016112284A1 as compound 183c, potently inhibits histone demethylase KDM2B, with cancer research potential.Fórmula:C25H30N2O2Cor e Forma:SolidPeso molecular:390.521,2-Didecanoylglycerol
CAS:1,2-Didecanoylglycerol has functions as bioregulator of protein kinase C in human platelets.Fórmula:C23H44O5Cor e Forma:SolidPeso molecular:400.59Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Fórmula:C6H14ClN3Cor e Forma:SolidPeso molecular:163.65SIRT2-IN-11
CAS:SIRT2-IN-11 (AEM1), a SIRT2 inhibitor (IC50 18.5μM), induces apoptosis and affects p53, used in cancer research.Fórmula:C21H22N2OCor e Forma:SolidPeso molecular:318.41HIF-1/2α-IN-2
CAS:HIF-1/2α-IN-2 is a potent inhibitor of HIF-1/2α, which effectively reduces the levels of HIF-1/2α.Fórmula:C16H11FN4O2SCor e Forma:SolidPeso molecular:342.35Thi-DPPY
CAS:Thi-DPPY: Potent JAK3/BTK inhibitor (IC50: 1.38/62.4 nM), anti-proliferative, anti-inflammatory, potential in IPF research.Fórmula:C28H28ClN5O4SCor e Forma:SolidPeso molecular:566.07Peficitinib hydrobromide
CAS:Peficitinib hydrobromide is used in the treatment of Psoriasis and Rheumatoid Arthritis.Fórmula:C18H23BrN4O2Cor e Forma:SolidPeso molecular:407.312M133
CAS:M133 is a selective histone deacetylase HDAC1 and HDAC2 inhibitor and potent antitumor agent.Fórmula:C23H24N4OS2Cor e Forma:SolidPeso molecular:436.59Bizine
CAS:Bizine, a Phenelzine analogue, selectively inhibits LSD1 (Ki=59 nM), modulates histone methylation in cancer, and may have neuroprotective uses.Fórmula:C18H23N3OCor e Forma:SolidPeso molecular:297.39Y08284
CAS:Y08284: selective CBP bromodomain inhibitor, IC50: 4.21 nM, oral. Halts prostate cancer cell growth; anti-tumor.Fórmula:C26H25FN4O4Cor e Forma:SolidPeso molecular:476.5HIF-PHD-IN-2
CAS:HIF-PHD-IN-2 (compound 25) is a highly effective PHD inhibitor, displaying IC50 values below 100 nM for PHD1, PHD2, and PHD3 [1].Fórmula:C17H15N5O3SCor e Forma:SolidPeso molecular:369.4
