Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2612 produtos de "Cromatina/Epigenética"
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JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Fórmula:C26H32FN9O2Pureza:98%Cor e Forma:SolidPeso molecular:521.59BRD4 Inhibitor-26
BRD4 Inhibitor-26: blocks BRD4 (BD1 and BD2) with IC50 of 0.82 μM & 1.94 μM; used in ovarian cancer research.Fórmula:C29H27N5O6SCor e Forma:SolidPeso molecular:573.62CeMMEC2
CAS:CeMMEC2, a novel inhibitor of BRD4, binds both the first and the second bromodomain of BRD4.Fórmula:C14H19N5Cor e Forma:SolidPeso molecular:257.33HDAC6/8/BRPF1-IN-1
CAS:HDAC6/8/BRPF1-IN-1 is a cancer-research inhibitor for HDAC6, HDAC8, BRPF1 with IC50: 344-908 nM and Kd: 175.2 nM.Fórmula:C18H17N3O5SCor e Forma:SolidPeso molecular:387.41Povorcitinib
CAS:Povorcitinib is a highly potent and selective JAK1 inhibitor with significant potential for the investigation of cutaneous lupus erythematosus (CLE) and Lichen planus (LP).Fórmula:C23H22F5N7OCor e Forma:SolidPeso molecular:507.469ART-IN-1
CAS:ART-IN-1 (compound 7) is a selective inhibitor of PARP with IC 50 s of 19, 22, 2.4, >100, 1.1 μM for PARP2, TNKS2, PARP10, PARP14, PARP15, respectively [1].Fórmula:C14H13NO2SCor e Forma:SolidPeso molecular:259.32MAT2A-IN-7
CAS:MAT2A-IN-7 inhibits MAT2A in various cancers, especially MTAP-deficient cancer cells, with potential for research use.Fórmula:C17H13ClF3N3O2Cor e Forma:SolidPeso molecular:383.75SRTCX1003
CAS:SRTCX1003, a SIRT1 activator, suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity.Fórmula:C23H23N5O3SCor e Forma:SolidPeso molecular:449.53Aurora Kinases-IN-3
CAS:Aurora Kinases-IN-3 is an oral AURKB inhibitor that disrupts its mitotic localization, not its H3 Ser10 phosphorylation.Fórmula:C20H16F3N3O4Cor e Forma:SolidPeso molecular:419.35PBRM1-BD2-IN-6
CAS:PBRM1-BD2-IN-6: potent PBRM1 inhibitor with 0.22 µM IC50, anti-cancer research potential.Fórmula:C16H15ClN2OCor e Forma:SolidPeso molecular:286.76A2AAR/HDAC-IN-2
CAS:A2AAR/HDAC-IN-2: potent dual A2AAR/HDAC inhib., Ki 10.3 nM, IC50 18.5 nM, anti-tumor potential.Fórmula:C23H26N6O4Cor e Forma:SolidPeso molecular:450.49KCN1
CAS:KCN1: a synthetic sulfonamide, nanomolar HIF inhibitor with preclinical anti-glioma and anti-pancreatic cancer effects.Fórmula:C26H27NO5SCor e Forma:SolidPeso molecular:465.56SIRT2-IN-10
CAS:SIRT2-IN-10 (Compound 12) is a potent inhibitor of SIRT2 (IC50: 1.3 μM), which can be used in the study of cancer and neurodegenerative diseases.Fórmula:C28H21N5OSCor e Forma:SolidPeso molecular:475.56Trotabresib
CAS:Trotabresib (CC-90010) is an orally active inhibitor of BET and can be used in studies about advanced solid tumors.Fórmula:C21H21NO4SPureza:99.86%Cor e Forma:SolidPeso molecular:383.46Ref: TM-T36395
1mg92,00€5mg188,00€10mg311,00€25mg528,00€50mg755,00€100mg1.017,00€1mL*10mM (DMSO)215,00€GPI-15427
CAS:GPI-15427: a potent PARP-1 inhibitor, crosses the blood-brain barrier, boosts TMZ's effects on CNS tumors, and sensitizes cancer to radiotherapy.Fórmula:C20H20N4O2Cor e Forma:SolidPeso molecular:348.4CPI-1612
CAS:CPI-1612: Oral EP300/CBP HAT inhibitor, IC50 8.1 nM, has anticancer properties.Fórmula:C27H26N6OCor e Forma:SolidPeso molecular:450.53ZLD2218
CAS:ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies.Fórmula:C22H18N4OCor e Forma:SolidPeso molecular:354.4BRM/BRG1 ATP Inhibitor-3
CAS:BRM/BRG1 ATP Inhibitor-3 targets BRM/BRG1 (IC50: 10.4/19.3 nM) for cancer/BAF disorder research.Fórmula:C26H25N5O2S2Cor e Forma:SolidPeso molecular:503.64PF-00956980
CAS:PF-00956980: reversible JAK inhibitor, IC50: JAK1 (2.2μM), JAK2 (23.1μM), JAK3 (59.9μM), for lung/skin inflammation research.Fórmula:C18H26N6OCor e Forma:SolidPeso molecular:342.44CBP/p300-IN-10
CAS:CBP/p300-IN-10, potent EP300/CREBBP inhibitor; IC50: 26 nM/39 nM. Potential for cancer research.Fórmula:C25H24F5N5O3Cor e Forma:SolidPeso molecular:537.48
