Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2613 produtos de "Cromatina/Epigenética"
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FAK/aurora kinase-IN-1
CAS:FAK/aurora kinase-IN-1, a dual inhibitor of FAK and aurora kinase, has IC50 values of 6.61 nM and 0.91 nM respectively, and demonstrates anticancer effects (WO2018019252A1; compound 11) [1].Fórmula:C23H24ClN7O3Cor e Forma:SolidPeso molecular:481.93HDAC-IN-30
CAS:HDAC-IN-30 is a potent HDAC inhibitor targeting HDAC1, 2, 3, 6, and 8 with strong antitumor efficacy.
Fórmula:C22H23N5O3Cor e Forma:SolidPeso molecular:405.45ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Cor e Forma:SolidPeso molecular:355.43EZM 2302
CAS:EZM 2302 (GSK3359088) is a selective, and orally available arginine methyltransferase CARM1 inhibitor (IC50: 6 nM).Cost-effective and quality-assured.Fórmula:C29H37ClN6O5Pureza:97.47% - ≥98%Cor e Forma:SolidPeso molecular:585.09NSC 698600
CAS:NSC 698600 is a potent inhibitor of PCAF(p300/CBP-associated factor) with IC 50 of 6.51 μM that shows good inhibition activity of cancer cell proliferation [1].Fórmula:C14H12N2O2SCor e Forma:SolidPeso molecular:272.32SPC-180002
CAS:SPC-180002, a dual SIRT1/3 inhibitor, exhibits IC50 values of 1.13 and 5.41 μM for SIRT1 and SIRT3, respectively.Fórmula:C18H23NO4Pureza:98%Cor e Forma:SolidPeso molecular:317.38HPCG
CAS:HPCG is an inhibitor of HIF-1α prolyl hydroxylase.Fórmula:C8H8N2O4Cor e Forma:SolidPeso molecular:196.16Sirtuin modulator 4
CAS:Sirtuin modulator 4 inhibits SIRT1 (EC50: 51-100 μM), may extend cell life and prevent diseases like diabetes and cancer.Fórmula:C18H10N2O2SCor e Forma:SolidPeso molecular:318.35KU-0058684
CAS:KU-0058684 is a potent PARP and DNA-PK inhibitors.Fórmula:C19H14FN3O3Cor e Forma:SolidPeso molecular:351.33ZIKV-IN-2
CAS:ZIKV-IN-2 blocks ZIKV replication, is a strong NS5 MTase inhibitor (IC50: 38.86 μM), and aids Zika virus research.Fórmula:C39H42O4Cor e Forma:SolidPeso molecular:574.75iBRD4-BD1
CAS:iBRD4-BD1 inhibits BRD4 bromodomain selectively with 12 nM IC50, useful in inflammation and cancer research.Fórmula:C29H30F3N5OCor e Forma:SolidPeso molecular:521.58GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Fórmula:C42H55NO8Pureza:98%Cor e Forma:SolidPeso molecular:701.89CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Fórmula:C36H48N6O3Pureza:99.5%Cor e Forma:SolidPeso molecular:612.8Binucleine 2
CAS:Binucleine 2: Drosophila Aurora B kinase inhibitor (Ki=0.36μM), dose-dependent, minimal effect on human/X. laevis kinases, disrupts mitosis in fly cells.Fórmula:C13H11ClFN5Cor e Forma:SolidPeso molecular:291.71UMB-32
CAS:UMB-32: Potent, selective BRD4 inhibitor, Kd 550 nM, IC50 637 nM, also targets TAF1.Fórmula:C21H23N5OCor e Forma:SolidPeso molecular:361.44Bromodomain inhibitor-10
CAS:Bromodomain inhibitor-10 (compound 128) suppresses BRD4-1/2 with Kd 15 nM/2.5 μM and curbs IL12p40 production.Fórmula:C20H20N4O3Cor e Forma:SolidPeso molecular:364.4FNDR-20123 free base
CAS:FNDR-20123 is a safe, oral first-in-class anti-malarial HDAC inhibitor with low IC50s against Plasmodium and human HDACs.Fórmula:C21H23N5O2Cor e Forma:SolidPeso molecular:377.44CAY10669
CAS:CAY10669 inhibits PCAF (IC50 = 662 μM), is twice as potent as anacardic acid, and reduces H4 acetylation in HepG2 cells at 30-60 μM.Fórmula:C20H22O4Cor e Forma:SolidPeso molecular:326.39OM-137
CAS:OM137 inhibits Aurora kinases, impedes cell growth at high doses, and enhances low-dose paclitaxel effects.Fórmula:C13H14N4O3SCor e Forma:SolidPeso molecular:306.34
