Cromatina/Epigenética
Os inibidores de cromatina/epigenética são compostos que modulam a estrutura e função da cromatina ou interferem em modificações epigenéticas, como a metilação do DNA e a modificação de histonas. Esses inibidores são ferramentas essenciais para estudar a regulação da expressão gênica e o papel da epigenética em doenças como o câncer, distúrbios neurológicos e anomalias do desenvolvimento. Ao direcionar os processos epigenéticos, esses inibidores podem alterar os padrões de expressão gênica e oferecer novas vias terapêuticas. Na CymitQuimica, oferecemos uma ampla seleção de inibidores de cromatina/epigenética de alta qualidade para apoiar sua pesquisa em biologia molecular, genética e epigenética.
Subcategorias de "Cromatina/Epigenética"
Foram encontrados 2613 produtos de "Cromatina/Epigenética"
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UNC6212 (Kme2)
UNC6212 (Kme2), a dimethyllysine (Kme2)-containing ligand, has a K D for CBX5 of 5.7 μM .Fórmula:C39H53N7O11Cor e Forma:SolidPeso molecular:795.88TC-E 5001
CAS:dual tankyrase (TNKS) inhibitorFórmula:C20H19N5O3SPureza:98%Cor e Forma:SolidPeso molecular:409.46BET-BAY 002 (S enantiomer)
CAS:The S-enantiomer of BET-BAY 002, referred to as BET-BAY 002 S enantiomer, is a potent inhibitor of BET (Bromodomain and Extra-Terminal motif proteins).Fórmula:C22H18ClN5OPureza:98%Cor e Forma:SolidPeso molecular:403.86Bromodomain IN-1
CAS:Bromodomain IN-1 is an inhibitor of Bromodomain.Fórmula:C22H23ClN4O3SPureza:98%Cor e Forma:SolidPeso molecular:458.96BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34JAK3/BTK-IN-2
CAS:JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.
Fórmula:C25H32N8O2Pureza:99.64% - 99.87%Cor e Forma:SolidPeso molecular:476.57HDAC/CK2-IN-1
CAS:HDAC/CK2-IN-1 (compound 38) acts as an inhibitor of HDAC1 (IC 50 = 1.46 μM), HDAC6 (IC 50 = 0.66 μM), and CK2 (IC 50 = 3.67 μM). It demonstrates promising antiproliferative effects on various cell lines, including Jurkat, MCF-7, HCT-116, and HL-60.Fórmula:C15H18Br4N4O2Cor e Forma:SolidPeso molecular:605.95PARP-2/1-IN-2
CAS:PARP-2/1-IN-2, Veliparib's enantiomer, inhibits PARP-1/2 (Ki: 5/2 nM) with 3 nM EC50 in cell assay.Fórmula:C13H16N4OCor e Forma:SolidPeso molecular:244.29HDAC/NAMPT-IN-1
CAS:HDAC/NAMPT-IN-1 (compound 39h) simultaneously inhibits HDAC and NAMPT, exhibiting IC 50 values ranging from 0.72 to 37081 nM for HDAC and 1618 nM for NAMPT [1].Fórmula:C19H21N5O2Cor e Forma:SolidPeso molecular:351.4Tyk2-IN-5
CAS:Tyk2-IN-5 is a selective and orally active inhibitor of Tyk2 JH2 (Ki: 0.086 nM for Tyk2 JH2; IC50: 25 nM for IFNα).Fórmula:C21H19FN8O2Pureza:98%Cor e Forma:SolidPeso molecular:434.43DDO-2093 dihydrochloride
DDO-2093 dihydrochloride: potent MLL1-WDR5 inhibitor, IC50=8.6 nM, Kd=11.6 nM, antitumor.Fórmula:C29H39Cl3FN9O3Cor e Forma:SolidPeso molecular:687.04UNC0379 TFA
CAS:UNC0379 TFA inhibits SETD8 (IC50: 7.3 μM), selective for 15+ methyltransferases.Fórmula:C25H36F3N5O4Cor e Forma:SolidPeso molecular:527.589IACS-9571
CAS:IACS-9571 is a selective and potent inhibitor of TRIM24 and BRPF1, (IC50: 8 nM for TRIM24; Kds: 31 nM and 14 nM for TRIM24 and BRPF1).Fórmula:C32H42N4O8SPureza:98%Cor e Forma:SolidPeso molecular:642.76YM-53601
CAS:YM-53601 is an SQS inhibitor that inhibits adipogenic biosynthesis and lipid secretion in rodents.YM-53601 is a cholesterol-lowering agent that inhibits FDFT1.Fórmula:C21H22ClFN2OPureza:99.65%Cor e Forma:SolidPeso molecular:372.86MI-2-2
CAS:MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.Fórmula:C17H20F3N5S2Pureza:99.65%Cor e Forma:SolidPeso molecular:415.5CX-6258
CAS:CX-6258 is an orally valid Pim 1/2/3 kinase(IC50=5 nM/25 nM/16 nM) inhibitor. It has good biological activity and kinase specificity.Fórmula:C26H24ClN3O3Pureza:97.46%Cor e Forma:SolidPeso molecular:461.94Ref: TM-T1834
1mg34,00€5mg75,00€1mL*10mM (DMSO)77,00€10mg101,00€25mg197,00€50mg295,00€100mg447,00€200mg623,00€Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Fórmula:C18H18Cl2N4OPureza:98.16%Cor e Forma:SolidPeso molecular:377.27F-amidine
CAS:F-amidine is a bioavailable irreversible PAD4 inactivator.Fórmula:C14H19FN4O2Cor e Forma:SolidPeso molecular:294.32KD 5170
CAS:KD 5170, a pan inhibitor of histone deacetylases (HDACs), demonstrates widespread antitumor activity both in vitro and in vivo [1].Fórmula:C20H25N3O5S2Cor e Forma:SolidPeso molecular:451.56PI3K/Akt/CREB activator 1
CAS:PI3K/Akt/CREB activator 1 (AE-18) is an iNOS inhibitor that can be used to study vascular dementia and Parkinson's.Fórmula:C19H15F4NO3Cor e Forma:SolidPeso molecular:381.32
