Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 129 produtos para "Topoisomerase".
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Banoxantrone-D12 dihydrochloride
CAS:Banoxantrone D12, a deuterium-labeled version, transforms into DNA-binding topoisomerase II inhibitor AQ4 upon reduction.Fórmula:C22H30Cl2N4O6Pureza:98%Cor e Forma:SolidPeso molecular:529.48Top1/2-IN-1
Compound 23, known as Top1/2-IN-1, is a dual inhibitor of Top1/2 that can be administered orally and exhibits antiproliferative effects. It induces apoptosis and cell cycle arrest in cancer cells by damaging DNA and elevating reactive oxygen species levels. Additionally, Top1/2-IN-1 demonstrates antitumor activity in vivo within xenograft models.Fórmula:C21H21N3O2Cor e Forma:SolidPeso molecular:347.41TAK1 inhibitor
CAS:TAK1 inhibitor is an inhibitor, which can inhibit MCF-7, A549, DU-145 and MDA MB-231, with IC50 of 0.021, 0.14, 0.064 and 0.19, respectively.Fórmula:C22H19ClN6O2SPureza:98%Cor e Forma:SolidPeso molecular:466.94Chimmitecan
CAS:Chimmitecan ((S)-9-Allyl-10-hydroxycamptothecin) is a potent inhibitor of topoisomerase I and displays outstanding activity in vitro and in vivo.Fórmula:C23H20N2O5Pureza:98.35%Cor e Forma:Yellow SolidPeso molecular:404.42Topoisomerase II inhibitor 19
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and a topoisomerase II inhibitor with an IC50 of 0.34 μM. It induces damage in ctDNA.Fórmula:C27H16ClN3OSPeso molecular:465.07026Topoisomerase IIα-IN-9
CAS:Topoisomerase IIα-IN-9 ,with CAS No. 16346-97-7, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Topoisomerase IIα-IN-9 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C14H14O4SCor e Forma:SolidPeso molecular:278.32Merbarone
CAS:Merbarone is a Type II DNA topoisomerase inhibitor that suppresses the catalytic activity of human topoisomerase IIα by blocking DNA cleavage, subsequently inducing activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix, Merbarone triggers apoptosis in CEM cells through activation of ICE/CED-3-like proteases, making it a mechanistically informative compound for studying DNA damage responses and apoptosis pathways.Fórmula:C11H9N3O3SPureza:99.51%Cor e Forma:SolidPeso molecular:263.27Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Fórmula:C22H21N3O5Pureza:97.49%Cor e Forma:SolidPeso molecular:407.42Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Fórmula:C25H27N5O10Pureza:98.70% - 99.11%Cor e Forma:Blue SolidPeso molecular:557.21EIDD-1931
CAS:EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.Fórmula:C9H13N3O6Pureza:99.14% - 99.73%Cor e Forma:SolidPeso molecular:259.22Aurintricarboxylic acid
CAS:Aurintricarboxylic acid (NSC-4056) blocks nucleases and topoisomerases, stopping nucleic acid binding.Fórmula:C22H14O9Pureza:85% - 97.1%Cor e Forma:Deep Red Coarse Crystalline PowderPeso molecular:422.34Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Fórmula:C18H20ClN5O4SPureza:99.84%Cor e Forma:SolidPeso molecular:437.9Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Fórmula:C30H48O3Pureza:98.22% - 99.7%Cor e Forma:White SolidPeso molecular:456.70Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Fórmula:C26H27NO9·HClPureza:98.91% - 99.96%Cor e Forma:SolidPeso molecular:533.95Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Fórmula:C23H23N3O5Pureza:96.14% - 98.23%Cor e Forma:Yellow SolidPeso molecular:421.45SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Fórmula:C22H20N2O5Pureza:98% - 99.97%Cor e Forma:Yellow SolidPeso molecular:392.40Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Fórmula:C15H12O3Pureza:98.07% - 99.18%Cor e Forma:White SolidPeso molecular:240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Fórmula:C22H22N8Pureza:96.22% - 97.13%Cor e Forma:Orange SolidPeso molecular:398.469-Hydroxycamptothecin
CAS:9-Hydroxycampothecin is a camptothecin derivative with anticancer activity.Fórmula:C20H16N2O5Pureza:98.28%Cor e Forma:Yellow SolidPeso molecular:364.35
