Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 127 produtos de "Topoisomerase"
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Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Cor e Forma:SolidPeso molecular:383.82Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Fórmula:C36H30O16Pureza:98.64% - 99.49%Cor e Forma:SolidPeso molecular:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Fórmula:C21H18N2O5Pureza:98.49% - 99.56%Cor e Forma:SolidPeso molecular:378.38Mitoxantrone
CAS:Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.Fórmula:C22H28N4O6Pureza:96.29% - 98.74%Cor e Forma:Blue PowderPeso molecular:444.48β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Fórmula:C15H14O3Pureza:99.76% - 99.88%Cor e Forma:SolidPeso molecular:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Fórmula:C17H15ClN2Pureza:97.18%Cor e Forma:SolidPeso molecular:282.76Amonafide
CAS:Amonafide (NSC-308847, AS1413) causes DNA breaks via topoisomerase II, not topoisomerase I.Fórmula:C16H17N3O2Pureza:99.39%Cor e Forma:SolidPeso molecular:283.33Ref: TM-T6336
1mg37,00€2mg49,00€5mg75,00€1mL*10mM (DMSO)87,00€10mg93,00€25mg155,00€50mg266,00€100mg442,00€Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Fórmula:C19H16NO4Pureza:98.59% - 99.77%Cor e Forma:SolidPeso molecular:322.34Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Fórmula:C33H38N4O6Pureza:98% - 99.92%Cor e Forma:SolidPeso molecular:586.68Dxd
CAS:Dxd (OQM5SD32BQ) is a potent DNA topoisomerase I inhibitor (IC50= 0.31 μM). Dxd was used as a conjugate drug for HER2-targeted ADCs. High-Quality, Low-Cost!Fórmula:C26H24FN3O6Pureza:98.21% - ≥98%Cor e Forma:SolidPeso molecular:493.481,4-Naphthoquinone
CAS:1,4-Naphthoquinone used as inhibitor for monoamine oxidase, DNA topoisomerase, and acetyltransferase.Fórmula:C10H6O2Pureza:99.24% - 99.56%Cor e Forma:SolidPeso molecular:158.15Bimolane
CAS:Bimolane is a topoisomerase II inhibitor.Fórmula:C20H32N6O6Pureza:99.13% - 99.29%Cor e Forma:SolidPeso molecular:452.5EIDD-1931
CAS:EIDD-1931 (Beta-d-N4-hydroxycytidine) is a ribonucleoside analog with antiviral activity. It inhibits replication of SARS-CoV, MERS-CoV, and SARS-CoV-2.
Fórmula:C9H13N3O6Pureza:99.14% - 99.73%Cor e Forma:SolidPeso molecular:259.22TAS-103 dihydrochloride
CAS:TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.Fórmula:C20H21Cl2N3O2Pureza:97.78%Cor e Forma:SolidPeso molecular:406.31Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Fórmula:C18H20FN3O4Pureza:98.14% - 99.80%Cor e Forma:Off-White To Yellow CrystalsPeso molecular:361.37Amsacrine hydrochloride
CAS:Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Fórmula:C21H20ClN3O3SPureza:99.05% - 99.92%Cor e Forma:SolidPeso molecular:429.92Coralyne chloride
CAS:Coralyne chloride is a protoberberine with strong anticancer activity.Fórmula:C22H22ClNO4Pureza:98.88%Cor e Forma:SolidPeso molecular:399.87Levofloxacin hydrochloride
CAS:Levofloxacin is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity.Fórmula:C18H21ClFN3O4Pureza:99.78% - 99.98%Cor e Forma:SolidPeso molecular:397.8Belotecan hydrochloride
CAS:Belotecan hydrochloride (CKD-602) is a synthetic water-soluble camptothecin derivative and topoisomerase I inhibitor with potential antitumor activityFórmula:C25H28ClN3O4Pureza:99.63% - ≥95%Cor e Forma:SolidPeso molecular:469.96Ref: TM-T7551
1mg34,00€5mg66,00€1mL*10mM (DMSO)69,00€10mg90,00€25mg144,00€50mg200,00€100mg280,00€200mg416,00€Berberine hydrogen sulphate
CAS:Berberine hydrogen sulphate, a plant alkaloid, has broad antimicrobial effects on bacteria, fungi, and protozoa.Fórmula:C20H19NO8SPureza:99% - 99.82%Cor e Forma:Yellow Crystals Off-White To Yellow PowderPeso molecular:433.43
