Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 135 produtos de "Topoisomerase"
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Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFórmula:C23H15Br2FN2Pureza:98%Cor e Forma:SolidPeso molecular:498.19NH2-methylpropanamide-Exatecan TFA
CAS:Exatecan TFA, a methylpropanamide-modified derivative of the common ADC cytotoxin Exatecan, serves as a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM (0.Fórmula:C30H30F4N4O7Pureza:98%Cor e Forma:SolidPeso molecular:634.58Trovafloxacin mesylate
CAS:Trovafloxacin: broad-spectrum fluoroquinolone, blocks DNA gyrase/topoisomerase IV and PANX1 channel (IC50=4μM).Fórmula:C21H19F3N4O6SPureza:99.18%Cor e Forma:SolidPeso molecular:512.469-Chloromethyl-10-hydroxy-11-F-Camptothecin
CAS:9-Chloromethyl-10-hydroxy-11-F-Camptothecin, a novel derivative of camptothecin, functions as a DNA topoisomerase I (Topo I) inhibitor with potentialFórmula:C22H18ClFN2O4Pureza:98%Cor e Forma:SolidPeso molecular:428.84Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Fórmula:C21H24N4OPureza:98%Cor e Forma:SolidPeso molecular:348.44Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Fórmula:C25H27N3O7Cor e Forma:SolidPeso molecular:481.498Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Fórmula:C23H22FN3O4Cor e Forma:SolidPeso molecular:423.44Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Fórmula:C18H13ClN2O3Cor e Forma:SolidPeso molecular:340.76Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H25N3O5Pureza:98.47%Cor e Forma:SolidPeso molecular:447.48LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Fórmula:C22H19FN2O5Cor e Forma:SolidPeso molecular:410.4TH1338
CAS:TH1338 is an orally active camptothecin derivative with significant blood-brain barrier permeability and cytotoxicity, used in cancer research.
Fórmula:C22H21N3O4Pureza:98.77%Cor e Forma:SolidPeso molecular:391.42Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Fórmula:C20H21N3OSCor e Forma:SolidPeso molecular:351.47Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.
Fórmula:C25H28N2O4SiPureza:98%Cor e Forma:SolidPeso molecular:448.59Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Fórmula:C29H28N4O11Pureza:98%Cor e Forma:SolidPeso molecular:608.55Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Fórmula:C18H10O7Cor e Forma:SolidPeso molecular:338.27
