Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 136 produtos para "Topoisomerase".
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Topoisomerase I inhibitor 9
CAS:Topoisomerase I Inhibitor 9 (compound 3d), a specific inhibitor of leishmanial topoisomerase IB, exhibits antileishmanial activity, demonstrating an IC50 valueFórmula:C23H15Br2FN2Pureza:98%Cor e Forma:SolidPeso molecular:498.19Saintopin
CAS:Saintopin is an antitumor antibiotic and an inhibitor of DNA topoisomerases I and II, which induces DNA cleavage [1] [2].Fórmula:C18H10O7Cor e Forma:SolidPeso molecular:338.27PNU-142586 sodium
CAS:PNU-142586 sodium is the primary metabolite of Linezolid. It inhibits the activity of DNA topoisomerase 2-α (TOP2A) and DNA topoisomerase 2-β (TOP2B). By blocking the binding of DNA to TOP2 and inhibiting ATP hydrolysis, PNU-142586 interferes with DNA replication and transcription, leading to antiproliferative and cytotoxic effects, including mitochondrial dysfunction. It is useful for studying Linezolid-induced hematotoxicity and its molecular mechanisms.Fórmula:C16H20FN3NaO6Peso molecular:392.33Topotecan acetate
CAS:Topotecan acetate is an inhibitor of topoisomerase.Fórmula:C25H27N3O7Cor e Forma:SolidPeso molecular:481.4978Sobuzoxane
CAS:Sobuzoxane is an orally active topoisomerase II inhibitor, used in relapsed non-Hodgkin lymphoma research.Fórmula:C22H34N4O10Pureza:99.81%Peso molecular:514.53Topoisomerase I/II inhibitor 7
CAS:Compound 5h (Topoisomerase I/II inhibitor 7) is a Topoisomerase I/II inhibitor.Fórmula:C18H13ClN2O3Cor e Forma:SolidPeso molecular:340.76Anticancer agent 215
CAS:Anticanceragent 215 (1) is a camptothecin derivative with IC50 values of 5.2 nM and 8.2 nM against MCF-7 and MDA-MB-231 cells, respectively.Fórmula:C23H22FN3O4Cor e Forma:SolidPeso molecular:423.44LMP517
CAS:LMP517 (NSC 781517), an indenoisoquinoline, is a potent dual TOP1 and TOP2 inhibitor that shows better antitumor activity than its parent compound LMP744 against H82 (Small Cell Lung Cancer) xenografts, inducing TOP1 cleavage complexes (TOP1ccs) and TOP2ccs [1].Fórmula:C22H19FN2O5Cor e Forma:SolidPeso molecular:410.4Gimatecan
CAS:Gimatecan (STI481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity.Fórmula:C25H25N3O5Pureza:98.47%Cor e Forma:Yellow SolidPeso molecular:447.4831Intoplicine
CAS:Intoplicine is an inhibitor of DNA topoisomerase I and II.Fórmula:C21H24N4OPureza:98%Cor e Forma:SolidPeso molecular:348.4415Edotecarin
CAS:Edotecarin is a potent topoisomerase I inhibitor. It can decrease single-strand DNA cleavage (IC50: 50 nM).Fórmula:C29H28N4O11Pureza:98%Cor e Forma:SolidPeso molecular:608.55Topobexin
CAS:Topobexin (Topobexin 9) is a highly selective TOP2B inhibitor. It selectively inhibits TOP2B in vitro and stabilizes TOP2B on DNA. Topobexin offers significant protection to cardiomyocytes against DAU-induced damage. In rabbit models, Topobexin prevents anthracycline-induced cardiotoxicity and the decrease in left ventricular contractile function caused by DAU.Fórmula:C29H35N3O4Peso molecular:489.61meso-Tetra(4-pyridyl)porphine
CAS:meso-Tetra(4-pyridyl)porphine (Compound 10) is a porphyrin derivative. It acts as a weak inhibitor of human topoisomerase I (Top1), with an EC50 greater than 50 µM. This compound can be utilized in cancer research.Fórmula:C40H26N8Peso molecular:618.688Topoisomerase II inhibitor 18
CAS:Topoisomerase II inhibitor 18 (Compound IV), a Quinoxaline derivative, exhibits an IC 50 of 7.5 μM in inhibiting topoisomerase II. It impedes PC-3 cell proliferation, arrests the cell cycle at the S phase, and induces apoptosis. Moreover, this compound demonstrates substantial antitumor activity against cancer [1].Fórmula:C20H21N3OSCor e Forma:SolidPeso molecular:351.47Karenitecin
CAS:Karenitecin (Cositecan) is an inhibitor of topoisomerase I. It has potent anti-cancer activity.Fórmula:C25H28N2O4SiPureza:98%Cor e Forma:SolidPeso molecular:448.5863Suptopin-2
CAS:Sutopin-2 is a topoisomerase II inhibitor that affects cell cycle progression and microtubule stability. It induces cell cycle arrest by regulating the nuclear-cytoplasmic transport of cyclin B1.Fórmula:C17H16O7Peso molecular:332.3047
