Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 129 produtos para "Topoisomerase".
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Exatecan Mesylate
CAS:Exatecan Mesylate (DX8951f) is a DNA topoisomerase I inhibitor (IC50: 2.2 μM, 0.975 μg/mL).Fórmula:C25H26FN3O7SPureza:97.32% - 99.95%Cor e Forma:SolidPeso molecular:531.55Nitidine chloride
CAS:1.Fórmula:C21H18ClNO4Pureza:96.59% - 99.55%Cor e Forma:SolidPeso molecular:383.82Rabdosiin
CAS:Rabdosiin ((+)-Rabdosiin) is a natural product, and has anti-allergic activity, anti-HIV activity and inhibition on DNA topoisomerase.Fórmula:C36H30O16Pureza:99.4% - 99.95%Cor e Forma:SolidPeso molecular:718.619-Methoxycamptothecin
CAS:9-Methoxycamptothecin (MCPT) has antitumour activities through topoisomerase inhibition.Fórmula:C21H18N2O5Pureza:99.22% - 99.56%Cor e Forma:SolidPeso molecular:378.38Mitoxantrone
CAS:Mitoxantrone: anthracenedione antibiotic, disrupts DNA/RNA replication, binds to topoisomerase II, less cardiotoxic than doxorubicin.Fórmula:C22H28N4O6Pureza:96.29% - 98.74%Cor e Forma:SolidPeso molecular:444.48β-Lapachone
CAS:β-Lapachone (ARQ-501) is a specific DNA topoisomerase I inhibitor, and no inhibitory activities against DNA topoisomerase II or ligase.Fórmula:C15H14O3Pureza:99.76% - 99.88%Cor e Forma:Red SolidPeso molecular:242.27Ellipticine hydrochloride
CAS:Ellipticine hydrochloride (NSC-71795 (hydrochloride)) is a potent antineoplastic agent; inhibits DNA topoisomerase II activities.Fórmula:C17H15ClN2Pureza:97.18%Cor e Forma:SolidPeso molecular:282.76Groenlandicine
CAS:Groenlandicine, a protoberberine alkaloid, inhibits HRAR (IC50: 154.2 μM), targets topoisomerase I, and shows potential as an anti-Alzheimer's agent.Fórmula:C19H16NO4Pureza:98.59% - 99.77%Cor e Forma:SolidPeso molecular:322.34Irinotecan
CAS:Irinotecan (CPT-11), a camptothecin derivative, inhibits topoisomerase I, used for colorectal cancer treatment.Fórmula:C33H38N4O6Pureza:98% - 99.92%Cor e Forma:SolidPeso molecular:586.68Bimolane
CAS:Bimolane is a topoisomerase II inhibitor.Fórmula:C20H32N6O6Pureza:99.13% - 99.29%Cor e Forma:SolidPeso molecular:452.5TAS-103 dihydrochloride
CAS:TAS-103 dihydrochloride (BMS-247615 dihydrochloride) is a novel anticancer agent targeting both topoisomerase (Topo) I and Topo II.Fórmula:C20H21Cl2N3O2Pureza:97.78%Cor e Forma:SolidPeso molecular:406.31Levofloxacin
CAS:Levofloxacin ((-)-Ofloxacin) is a synthetic fluoroquinolone antibiotic that prevents DNA replication. Cost-effective and quality-assured.Fórmula:C18H20FN3O4Pureza:98.14% - 99.93%Cor e Forma:SolidPeso molecular:361.37Amsacrine hydrochloride
CAS:Amsacrine hydrochloride (acridinyl anisidide hydrochloride) is topoisomerase II inhibitor , is used in the treatment of acute myelogenous leukemia.Fórmula:C21H20ClN3O3SPureza:99.05% - 99.92%Cor e Forma:SolidPeso molecular:429.92Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Fórmula:C27H29NO11Pureza:99.31% - 99.88%Cor e Forma:Red Crystalline Solid SolidPeso molecular:543.52IndiMitecan
CAS:IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].Fórmula:C25H21N3O6Pureza:98.53%Cor e Forma:SoildPeso molecular:459.45(±)-10-Hydroxycamptothecin
CAS:(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.Fórmula:C20H16N2O5Pureza:98% - 99.26%Cor e Forma:SolidPeso molecular:364.35Topo I/II-IN-1
Topo I/II-IN-1 (compound 7t) is an effective dual inhibitor of Topo I and Topo II. It exhibits significant cytotoxicity against the MCF-7 breast cancer cell line, with an IC50 value of 7.45 μM.Fórmula:C15H13N3S2Cor e Forma:SolidPeso molecular:299.414PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Fórmula:C32H35NO13Pureza:98.24%Cor e Forma:Red LiquidPeso molecular:641.62Ref: TM-T16557
1mg87,00€5mg178,00€1mL*10mM (DMSO)263,00€10mg326,00€25mg537,00€50mg735,00€100mg964,00€Ellipticine
CAS:Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Fórmula:C17H14N2Pureza:97.57% - >99.99%Cor e Forma:SolidPeso molecular:246.31Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Fórmula:C20H16N2O4Pureza:99.52% - 99.88%Cor e Forma:SolidPeso molecular:348.35
