Topoisomerase
As topoisomerases são enzimas que regulam a topologia do DNA durante processos como replicação, transcrição e segregação cromossômica, introduzindo quebras temporárias nas fitas de DNA para aliviar o estresse torsional. Os inibidores de topoisomerase interferem nesse processo, levando ao acúmulo de quebras de DNA e à indução da morte celular, particularmente em células de rápida divisão. Esses inibidores são amplamente utilizados como agentes quimioterápicos no tratamento do câncer. Na CymitQuimica, oferecemos uma ampla gama de inibidores de topoisomerase de alta qualidade para apoiar sua pesquisa em replicação de DNA, terapia do câncer e regulação do ciclo celular.
Foram encontrados 126 produtos de "Topoisomerase"
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Genz-644282
CAS:Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment.Fórmula:C22H21N3O5Pureza:97.49%Cor e Forma:SolidPeso molecular:407.42Gatifloxacin hydrochloride
CAS:Gatifloxacin hydrochloride, a fourth-gen fluoroquinolone antibiotic, blocks bacterial DNA rotase and topoisomerase IV.Fórmula:C19H23ClFN3O4Pureza:99.85% - 99.89%Cor e Forma:SolidPeso molecular:411.86Phenoxodiol
CAS:Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP)Fórmula:C15H12O3Pureza:98.07% - 99.18%Cor e Forma:SolidPeso molecular:240.25Ref: TM-T16522
1mg63,00€5mg137,00€1mL*10mM (DMSO)150,00€10mg215,00€25mg353,00€50mg537,00€100mg767,00€Betulinic acid
CAS:Betulinic acid, a lupane-type triterpene from white birch bark, has antiretroviral, antimalarial, anti-inflammatory, and anticancer properties.Fórmula:C30H48O3Pureza:98.22% - 99.7%Cor e Forma:White Crystalline PowderPeso molecular:456.70Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Fórmula:C26H27NO9·HClPureza:98.91% - 99.96%Cor e Forma:SolidPeso molecular:533.95Voreloxin hydrochloride
CAS:Voreloxin hydrochloride (SNS-595 hydrochloride) is a potent inhibitor of Topoisomerase II with broad-spectrum anti-tumor activity.Fórmula:C18H20ClN5O4SPureza:99.84%Cor e Forma:SolidPeso molecular:437.9SN-38
CAS:SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM).Fórmula:C22H20N2O5Pureza:98% - 99.97%Cor e Forma:Light-Yellow SolidPeso molecular:392.4Pixantrone dimaleate
CAS:Pixantrone dimaleate (Pixantrone Maleate) (BBR 2778 dimaleate) is an experimental antineoplastic drug.Fórmula:C25H27N5O10Pureza:98.70% - 99.11%Cor e Forma:SolidPeso molecular:557.21Topotecan
CAS:Topotecan (NSC-609669) is a Topoisomerase I inhibitor,and is an antineoplastic agent used to treat ovarian cancer that works by inhibiting DNA topoisomerases.Fórmula:C23H23N3O5Pureza:96.14% - 98.23%Cor e Forma:Light Yellow Needle Crystal Or Crystalline PowderPeso molecular:421.45Suramin Sodium Salt
CAS:Suramin Sodium Salt (BAY-205) is a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors.Fórmula:C51H34N6Na6O23S6Pureza:97.47% - 99.97%Cor e Forma:WhitePeso molecular:1429.15(S)-10-Hydroxycamptothecin
CAS:(S)-10-Hydroxycamptothecin (10-HCPT) is a DNA topoisomerase I inhibitor, utilized as a clinical therapy agent against hepatoma.Fórmula:C20H16N2O5Pureza:99.09% - 99.81%Cor e Forma:SolidPeso molecular:364.35Bisantrene
CAS:Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.Fórmula:C22H22N8Pureza:96.07% - 98.57%Cor e Forma:SolidPeso molecular:398.46Rubitecan
CAS:Rubitecan: a semisynthetic DNA topoisomerase I inhibitor with antitumor and antiviral effects.Fórmula:C20H15N3O6Pureza:97.54%Cor e Forma:Yellow Amorphous PowderPeso molecular:393.35IndiMitecan
CAS:IndiMitecan (LMP776) is an inhibitor of topoisomerase I (Top1) with anticancer activities [1].
Fórmula:C25H21N3O6Pureza:98.53%Cor e Forma:SoildPeso molecular:459.45(±)-10-Hydroxycamptothecin
CAS:(±)-10-Hydroxycamptothecin (Hydroxy Camptothecine) is an alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata.
Fórmula:C20H16N2O5Pureza:98% - 99.06%Cor e Forma:SolidPeso molecular:364.35Doxorubicin
CAS:Doxorubicin (Adriamycin) is a Topoisomerase II (Top2) inhibitor with antineoplastic activity.Fórmula:C27H29NO11Pureza:99.31%Cor e Forma:Red Crystalline Solid SolidPeso molecular:543.52PNU-159682
CAS:PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin.Fórmula:C32H35NO13Pureza:98.24%Cor e Forma:SolidPeso molecular:641.62Ref: TM-T16557
1mg87,00€5mg178,00€1mL*10mM (DMSO)263,00€10mg326,00€25mg537,00€50mg735,00€100mg964,00€Camptothecin
CAS:Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity.Fórmula:C20H16N2O4Pureza:99.52% - 99.88%Cor e Forma:Solid PowderPeso molecular:348.35Ellipticine
CAS:Ellipticine is a powerful cancer drug with different actions, IC50: 0.27-1.48 μM for leukemia, breast cancer, neuroblastoma, glioblastoma.Fórmula:C17H14N2Pureza:97.26% - 99.88%Cor e Forma:SolidPeso molecular:246.31PluriSIn #2
CAS:PluriSIn #2 is a selective topoisomerase II α (topo2α) transcription inhibitor exhibiting cytotoxicity towards undifferentiated, leukaemogenic hPSCs.Fórmula:C11H8FN3O3Pureza:98% - 99.79%Cor e Forma:SolidPeso molecular:249.2
