DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 459 produtos de "DNA Metiltransferase"
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GSK2807 Trifluoroacetate
CAS:GSK2807 Trifluoroacetate is a selective and SAM-competitive inhibitor of SMYD3 (Ki: 14 nM; IC50: 130 nM).Fórmula:C21H33F3N8O7Pureza:99.95%Cor e Forma:SolidPeso molecular:566.53Acedapsone
CAS:Acedapsone has antimalarial and antimicrobial action, but is mainly used as a depot leprostatic agent.Fórmula:C16H16N2O4SPureza:98%Cor e Forma:SolidPeso molecular:332.37Tazemetostat trihydrochloride
CAS:Tazemetostat trihydrochloride, an EZH2 inhibitor, orally active, IC50: 4nM (rat), Ki: 2.5nM (human), effective in peptide and nucleosome assays.Fórmula:C34H47Cl3N4O4Pureza:98%Cor e Forma:SolidPeso molecular:682.12TETi76
CAS:TETi76 is an orally active inhibitor from the TET family, demonstrating IC50 values of 1.5, 9.4, and 8.8 μM against TET1, TET2, and TET3, respectively. The compound competitively binds to the active sites of TET enzymes, reducing cytosine hydroxymethylation and restricting clonal growth in mutated TET2 in vitro and in vivo, without affecting the growth of normal hematopoietic progenitor cells. TETi76 is utilized in leukemia research.Fórmula:C10H16O5Cor e Forma:SolidPeso molecular:216.23MY-1B
CAS:MY-1B is a nitrogen-substituted butenamide stereoprobe that blocks stereoselective enrichment of NSUN2, binding selectively to the C271 of NSUN2.Fórmula:C22H18BrN3O2Pureza:99.81% - >99.99%Cor e Forma:SoildPeso molecular:436.3UNC0224
CAS:UNC0224 is a selective inhibitor of G9a with a Ki of 2.6 nM and IC50 of 15 nM. UNC0224 also potently inhibits GLP with assay-dependent IC50 values of 20-58 nM.Fórmula:C26H43N7O2Pureza:99.80%Cor e Forma:SolidPeso molecular:485.67Ref: TM-T17203
1mg51,00€2mg73,00€5mg97,00€10mg159,00€25mg354,00€50mg558,00€100mg797,00€500mg1.634,00€1mL*10mM (DMSO)107,00€GSK-1268997
CAS:GSK-1268997 is a bio-active chemical.Fórmula:C21H23N7O3SPureza:99.33% - 99.81%Cor e Forma:SolidPeso molecular:453.52DC_C66
CAS:DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Fórmula:C28H22NO2Pureza:98%Cor e Forma:SolidPeso molecular:404.48CSV0C018875
CAS:CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].Fórmula:C18H17ClN2OCor e Forma:SolidPeso molecular:312.79Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27PRMT5-IN-17
CAS:PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Fórmula:C26H33N7O2Cor e Forma:SolidPeso molecular:475.59BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36Furamidine dihydrochloride
CAS:Furamidine dihydrochloride is a cell-permeable, selective PRMT1 inhibitor that also binds AT-rich DNA. It blocks proliferation in leukemia cell lines.Fórmula:C18H18Cl2N4OPureza:98.16%Cor e Forma:SolidPeso molecular:377.27DNMT3A-IN-1
CAS:DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.66CM-579
CAS:CM-579 is a dual inhibitor of G9a and DNMT( IC50:16 nM, 32 nM for G9a and DNMT). It has potent in vitro cellular activity in a wide range of cancer cells.Fórmula:C29H40N4O3Pureza:99.23%Cor e Forma:SolidPeso molecular:492.65Ref: TM-T10840L
1mg52,00€5mg90,00€10mg131,00€25mg207,00€50mg303,00€100mg447,00€1mL*10mM (DMSO)117,00€GNA002
CAS:GNA002 is a highly potent, specific, and covalent EZH2 (Enhancer of zeste homolog 2) inhibitor (IC50: 1.1 μM).Fórmula:C42H55NO8Pureza:98%Cor e Forma:SolidPeso molecular:701.89ZLD1039
CAS:ZLD1039, an oral EZH2 inhibitor, shows strong PRC2 inhibition at low nanomolar IC50s, and halts breast cancer growth and spread.Fórmula:C36H48N6O3Pureza:99.5%Cor e Forma:SolidPeso molecular:612.8NSC-311068
CAS:NSC-311068: A selective TET1 inhibitor, reducing 5hmC and AML cell viability with high TET1.Fórmula:C10H6N4O4SCor e Forma:SolidPeso molecular:278.24EZH2-IN-11
CAS:EZH2-IN-11, a potent E2HZ inhibitor with potential for cancer treatment, is highlighted in patent WO2019204490A1.Fórmula:C28H36ClN3O5SCor e Forma:SolidPeso molecular:562.12
