DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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Fagaronine chloride
CAS:Fagaronine chloride is a potent inhibitor of Topoisomerases I.Fórmula:C21H20ClNO4Cor e Forma:SolidPeso molecular:385.84Lobelane Hydrochloride
CAS:Lobelane Hydrochloride is a vesicular monoamine transporter-2 (VMAT2) inhibitor.Fórmula:C22H30ClNCor e Forma:SolidPeso molecular:343.93NSD3-IN-3
CAS:"NSD3-IN-3, a potent anticancer agent, inhibits NSD3 (IC50: 1.86 μM) and hampers H460 lung cancer cell growth."Fórmula:C15H17N5O2SCor e Forma:SolidPeso molecular:331.39NSD3-IN-2
CAS:NSD3-IN-2: Potent NSD3 inhibitor, IC50 17.97μM, halts NSCLC growth (H460, H1299, H1650) with anticancer effects.Fórmula:C17H15N5OSCor e Forma:SolidPeso molecular:337.4MS453
CAS:MS453 is a potent and selective SETD8 inhibitor with an IC50 value of 804 nM.Fórmula:C20H27N5O3Cor e Forma:SolidPeso molecular:385.46CSV0C018875
CAS:CSV0C018875 is a quinoline-based EHMT2/G9a inhibitor with lower cytotoxicity than BIX-01294 [1].Fórmula:C18H17ClN2OCor e Forma:SolidPeso molecular:312.79Dot1L-IN-5
CAS:Dot1L-IN-5 is a potent inhibitor of the disruptor of telomeric silencing 1-like protein ( DOT1L ) with an IC 50 SPA DOT1L of 0.17 nM [1].Fórmula:C23H19ClF2N8O5SCor e Forma:SolidPeso molecular:592.96Dihydro-5-azacytidine acetate
CAS:Dihydro-5-azacytidine acetate (DHAC), a nucleoside analog, becomes integrated into DNA, thereby inhibiting DNA methylation, and exhibits antitumor activity [1Fórmula:C10H18N4O7Pureza:98%Cor e Forma:SolidPeso molecular:306.27DC_C66
CAS:DC_C66 selectively inhibits CARM1 with IC50 of 1.8μM; also affects PRMT1, 6, 5. It's cell-permeable.Fórmula:C28H22NO2Pureza:98%Cor e Forma:SolidPeso molecular:404.48PRMT5-IN-17
CAS:PRMT5-IN-17 is a PRMT5-blocking compound with anticancer properties, linked to epigenetic changes.Fórmula:C26H33N7O2Cor e Forma:SolidPeso molecular:475.59BAY-598 R-isomer
CAS:BAY-598 R-isomer, a SMYD2-selective inhibitor, is the R-enantiomer of BAY589, not targeting PAR1.Fórmula:C22H20Cl2F2N6O3Cor e Forma:SolidPeso molecular:525.34CPI-905
CAS:CPI-905 is a potent and selective EZH2 inhibitor with IC50 value of 39.5 nM.Fórmula:C18H20N2O5Cor e Forma:SolidPeso molecular:344.36G9a-IN-2
CAS:G9a-IN-2 (Compound 7i) is an inhibitor of the histone methyltransferase G9a, with an IC50 of 0.024 μM. It can reduce the levels of H3K9me2 and induce the expression of γ-globin mRNA. G9a-IN-2 shows potential for improving Sickle Cell Disease (SCD).Fórmula:C30H42N4O4Cor e Forma:SolidPeso molecular:522.68DNMT3A-IN-1
CAS:DNMT3A-IN-1 is a potent, selective DNMT3A inhibitor with KI 9.16-18.85 μM (AdoMet) and 11.37-23.34 μM (poly dI-dC).Fórmula:C30H38N6O4Cor e Forma:SolidPeso molecular:546.665-Aza-4'-thio-2'-deoxycytidine
CAS:5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd), a sulfur-containing deoxy-cytidine analog, serves as an orally active inhibitor of DNA methyltransferase I (DNMT1). It exhibits potential antitumor effects and DNA hypomethylating properties [1].Fórmula:C8H12N4O3SCor e Forma:SolidPeso molecular:244.27EZH2-IN-7
CAS:EZH2-IN-7 inhibits EZH2, reducing H3K27me3 and tumor growth (e.g., breast, prostate cancer, leukemia). Potential in cancer research.Fórmula:C31H37D2N5O3SCor e Forma:SolidPeso molecular:563.75Valemetostat tosylate
CAS:Valemetostat tosylate is a dual inhibitor of EZH1/2 and used in the research of relapsed/refractory peripheral T-cell lymphoma.Fórmula:C33H42ClN3O7SPureza:98%Cor e Forma:SolidPeso molecular:660.22RM65
CAS:RM65 is an arginine methyltransferase inhibitor.Fórmula:C34H32N2O4S2Pureza:98%Cor e Forma:SolidPeso molecular:596.76PRMT5-IN-C17
CAS:PRMT5-IN-C17 is a novel potent, selective, and cell active protein arginine methyltransferase 5 (PRMT5) inhibitor.Fórmula:C18H17N3O4SCor e Forma:SolidPeso molecular:371.41CSV0C018875 Hydrochloride
CAS:CSV0C018875 Hydrochloride: Novel G9a inhibitor with low toxicity, effective in enzyme/cell assays, outperforms BIX-0129.Fórmula:C18H18Cl2N2OCor e Forma:SolidPeso molecular:349.255
