DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 459 produtos para "DNA Metiltransferase".
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SKLB-03220
CAS:SKLB-03220 is an oral covalent EZH2 inhibitor, abolishing H3K27me3 marks and serving as a potent small-molecule tool for cancer epigenetics research.Fórmula:C33H40N4O4Pureza:97.01%Cor e Forma:Yellow SolidPeso molecular:556.71Dot1L-IN-9
Dot1L-IN-9 (Compound 12) is a DOT1L inhibitor with an IC50 of 125 nM. It effectively reduces H3K79 dimethylation and is utilized in leukemia research.Cor e Forma:Odour SolidSAH-EZH2
CAS:EZH2/EPP inhibitor, Kd 320 nM. Reduces EZH2, H3K27me3; halts MLL-AF9 leukemia growth; drives monocyte-macrophage differentiation.Fórmula:C155H256N48O40Pureza:98%Cor e Forma:SolidPeso molecular:3432.05EZH2-IN-5
CAS:EZH2-IN-5, potent EZH2 inhibitor; IC50: 1.52 nM (wild-type), 4.07 nM (Tyr641 mutant).Fórmula:C26H37BrN4O2Cor e Forma:SolidPeso molecular:517.512PROTAC EED degrader-1
PROTAC EED degrader-1 is a PROTAC targeting EED (pKD = 9.02), is a inhibitor of polycomb repressive complex 2 (PRC2) with pIC50 of 8.17.Fórmula:C55H60FN11O8SPureza:98%Cor e Forma:SolidPeso molecular:1054.2UNC4976 TFA
UNC4976 TFA boosts CBX7 chromodomain interaction with nucleic acids and blocks gene-specific H3K27me3 binding, while enhancing DNA/RNA attachment.Fórmula:C49H71F3N6O10Cor e Forma:SolidPeso molecular:961.12PRMT5-IN-43
CAS:PRMT5-IN-43 (compound 4A) is an inhibitor of PRMT5, primarily utilized in cancer research.Fórmula:C22H17ClF3N5O2Cor e Forma:SolidPeso molecular:475.85EEDi-5285
CAS:EEDi-5285: potent EED inhibitor, orally active, IC50=0.2nM, targets EED protein, anti-cancer properties.Fórmula:C24H22FN5O3SPureza:>99.99%Cor e Forma:SolidPeso molecular:479.53AS-99 TFA
CAS:AS-99 TFA is an ASH1L inhibitor (IC50=0.79 μM) with anti-leukemic activity. It induces apoptosis, downregulates MLL target genes, and reduces leukemia burden in vivo.Fórmula:C29H31F6N5O5S2Cor e Forma:Yellow SolidPeso molecular:707.71Tet1
CAS:Tet1 is a peptide with the sequence HLNILSTLWKYRC. It specifically binds to the neuronal ganglioside receptor GT1b, which gives it the ability to target neurons. Tet1 is suitable for research related to drug delivery.Fórmula:C76H119N21O18SCor e Forma:SolidPeso molecular:1646.95G9D-4
G9D-4 is an effective degrader of G9a with a DC50 value of 0.1 μM in PANC-1 cells, and it does not directly interfere with GLP proteins (DC50 greater than 10 μM). This compound plays a significant role in pancreatic cancer research.Cor e Forma:Odour SolidBBDDL2204
BBDDL2204 (compound 13) is a potent and selective covalent inhibitor of EZH2, demonstrating an IC50 of 2.5 nM against EZH2Y641F.Fórmula:C37H47N5O5SCor e Forma:SolidPeso molecular:673.32979MS-8709
CAS:MS-8709 is a potent and selective G9a/GLP PROTAC Degrader with a DC50(G9a) of 274 nM and a DC50(GLP) of 260 nM. It induces G9a/GLP protein degradation in a concentration-dependent and time-dependent manner via the ubiquitin-proteasome system, without affecting mRNA expression levels. MS-8709 demonstrates superior cell growth inhibition compared to the parent compound UNC0642 in prostate cancer, leukemia, and lung cancer cell models, and exhibits mouse pharmacokinetic characteristics suitable for in vivo efficacy studies.Fórmula:C64H95F2N11O7SPureza:99.98%Cor e Forma:White SolidPeso molecular:1200.57LLC0424
LLC0424 is a potent and selective degrader of the nuclear receptor-binding SET domain 2 (NSD2), with a DC50 of 20 nM. It reduces H3K36me2 levels and inhibits the growth of acute lymphoblastic leukemia (ALL) cell lines, making it useful for research in ALL.Cor e Forma:Odour SolidEPZ-719
CAS:EPZ-719 is a selective and orally available SETD2 inhibitor (IC50 = 0.005 μM), with anti-cancer activity, and can be used for hematological malignancies.Fórmula:C22H31FN4O3SPureza:99.95%Cor e Forma:White SolidPeso molecular:450.57A-893
CAS:A-893 is a cell-active inhibitor of Methyltransferase SMYD2 (IC 50 = 2.8 nM) .Fórmula:C29H38Cl2N4O4Cor e Forma:SolidPeso molecular:577.54PRMT3-IN-4
PRMT3-IN-4 (intermediate 15) is an inhibitor of Protein arginine methyltransferase 3 (PRMT3) and serves as the active control for SGC707. It can be utilized in the synthesis of PROTACs targeting PRMT3 and is applicable in research related to leukemia.Cor e Forma:Odour SolidDNMT1/HDAC-IN-1
DNMT1/HDAC-IN-1 (compound (R)-23a), a potent dual inhibitor targeting both DNMT1 and HDAC, exhibits impressive inhibitory effects specifically on HDAC1 (HDAC1:IC50=0.05 μM), a major HDAC isoform that interacts with DNMT1 across multiple protein complexes involved in the transcriptional silencing of TSGs. This compound has been shown to remodel the tumor immune microenvironment and induce tumor regression, effectively reversing cancer-specific epigenetic abnormalities.Cor e Forma:Odour SolidLarsucosterol Ammonium salt
CAS:Larsucosterol ammonium salt is a derivative of 25HC3S. It is a DNMT inhibitor, a LXR antagonist, an endogenous epigenetic modulator of lipid metabolism.Fórmula:C27H49NO5SPureza:>99.99% - >99.99%Cor e Forma:SolidPeso molecular:499.75UNC2399
CAS:UNC2399, a biotinylated version of UNC1999, functions as a selective degrader of EZH2 and exhibits strong in vitro efficacy against EZH2, demonstrated by its ICFórmula:C67H104N10O17SCor e Forma:SolidPeso molecular:1353.68
