DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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MS8511 HCl
MS8511 HCl is a G9a/GLP inhibitor with anticancer activity that can be used in the study of a variety of cancers including brain cancer.Fórmula:C28H42ClN5O3Pureza:98.9% - 98.96%Cor e Forma:SolidPeso molecular:532.12UNC 0631
CAS:UNC 0631 is a effectvie histone methyltransferase G9a inhibitor (IC50=4 nM).Fórmula:C37H61N7O2Pureza:97.42%Cor e Forma:SolidPeso molecular:635.93PARP/EZH2-IN-1
CAS:PARP/EZH2-IN-1: Dual PARP (IC50 6.87 nM) & EZH2 (IC50 36.51 nM) inhibitor, potential for BRCA-wild-type triple-negative breast cancer.Fórmula:C43H41FN8O5Cor e Forma:SolidPeso molecular:768.85DC-S239
CAS:Ethyl 2-amino-4-methyl-5-thiophene carboxylate is a SETD7 inhibitor (IC50=4.59μM) with anticancer properties.Fórmula:C15H15N3O5SPureza:99.37%Cor e Forma:SolidPeso molecular:349.36EZH2-IN-4
CAS:EZH2-IN-4, an oral EZH2 inhibitor, targets WT and mutant forms with IC50s of 0.923 nM and 2.65 nM, showing strong anti-cancer effects.Fórmula:C29H41N3O3SCor e Forma:SolidPeso molecular:511.73Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH
CAS:Tazemetostat de(methylene morpholine)-O-C3-O-C-COOH (Compound 21b), an EZH2 degrader, is employed in lymphoma research [1].Fórmula:C34H43N3O7Cor e Forma:SolidPeso molecular:605.72SETD7-IN-1
SETD7-IN-1 (compound 7), a PFI-2 analogue, acts as both a substrate and inhibitor of histone lysine methyltransferase SETD7, exhibiting an inhibitoryPureza:98%Cor e Forma:Odour SolidDDO-2093
CAS:DDO-2093 inhibits MLL1-WDR5 interaction (IC50: 8.6 nM, Kd: 11.6 nM), with strong antitumor properties and selectivity.Fórmula:C29H37ClFN9O3Cor e Forma:SolidPeso molecular:614.12Gintemetostat
CAS:Gintemetostat (KTX-1001) is a potent NSD2 inhibitor (IC50=0.001-0.01μM) for treating NSD2-dysregulated cancers.Fórmula:C25H26F4N8O2Cor e Forma:SolidPeso molecular:546.522'-Deoxy-2'-fluoro-β-D-arabinocytidine hydrochloride
CAS:2'-Deoxy-2'-fluoro-beta-D-arabinocytidine HCl inhibits DNA methyltransferase with potential anti-tumor properties.Fórmula:C9H13ClFN3O4Pureza:99.43%Cor e Forma:SolidPeso molecular:281.67(R)-HH2853
CAS:(R)-HH2853, a mutant EZH2 inhibitor, IC50 <100 nM for EZH2-Y641F, targets cancer/autoimmune diseases.Fórmula:C31H36F3N7O3Pureza:97.53% - 98.85%Cor e Forma:SolidPeso molecular:611.66AMI-1 free acid
CAS:<p>AMI-1: Potent reversible PRMT inhibitor; IC50: 8.8 μM (hPRMT1), 3.0 μM (yeast-Hmt1p); blocks substrate binding.</p>Fórmula:C21H16N2O9S2Pureza:97.8%Cor e Forma:SolidPeso molecular:504.49PROTAC EZH2 Degrader-1
CAS:PROTAC EZH2 Degrader-1 suppresses EZH2 methyltransferase activity with IC50 2.7 nM, serving as a potent tool in cancer research and EZH2 inhibition studies.Fórmula:C54H67N7O8Cor e Forma:SolidPeso molecular:942.15MS8511 hydrochloride
CAS:<p>MS8511 hydrochloride is a selective G9a/GLP inhibitor with IC50 values of 100 nM and 140 nM respectively, exhibiting covalent and irreversible characteristics.</p>Fórmula:C28H42ClN5O3Cor e Forma:SolidPeso molecular:532.12O6BTG-octylglucoside
CAS:O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor (IC50s: 10 nM and 32 nM in HeLa S3 cells and in vitro (cell extracts)).Fórmula:C24H34BrN5O7SPureza:98%Cor e Forma:SolidPeso molecular:616.53EZM0414 TFA
CAS:EZM0414 TFA (SETD2-IN-1 TFA) is a SETD2 inhibitor with anticancer and antiproliferative effects for the study of leukemia and immune dysfunction.Fórmula:C24H30F4N4O4Pureza:98.88%Cor e Forma:SolidPeso molecular:514.51DA-3003-1
CAS:DA-3003-1 (NSC 663284) is a Cdc25 dual specificity phosphatase inhibitor with antitumor activity and inhibits Cdc25B2, Cdc25A, Cdc25B2, and Cdc25C.Fórmula:C15H16ClN3O3Pureza:99.27% - 99.79%Cor e Forma:SolidPeso molecular:321.765'-Azido-5'-deoxyadenosine
CAS:5'-Azido-5'-deoxyadenosine is a purine nucleoside analogue, inhibit Trichomonas vaginalis and PRMT5 , click chemistry alkyne, DBCO, or BCN groups.Fórmula:C10H12N8O3Pureza:99.84%Cor e Forma:SolidPeso molecular:292.25EHMT2-IN-1
CAS:EHMT2-IN-1: potent EHMT inhibitor, for blood disorders/cancer research; IC50s <100 nM for EHMT1/2 peptides and cellular EHMT2.Fórmula:C18H23N7OCor e Forma:SolidPeso molecular:353.42EPZ020411
CAS:EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Fórmula:C25H38N4O3Cor e Forma:SolidPeso molecular:442.6
