DNA Metiltransferase
As metiltransferases de DNA (DNMTs) são enzimas que catalisam a adição de grupos metila a resíduos de citosina no DNA, levando ao silenciamento gênico. A metilação aberrante do DNA está associada a várias doenças, incluindo câncer. Inibidores de DNMT bloqueiam a atividade dessas enzimas, levando à reativação de genes silenciados e à indução de apoptose em células cancerígenas. Os inibidores de DNMT são amplamente utilizados em pesquisas epigenéticas e terapias contra o câncer. Na CymitQuimica, oferecemos uma gama de inibidores de DNMT de alta qualidade para apoiar sua pesquisa em epigenética, metilação de DNA e biologia do câncer.
Foram encontrados 455 produtos de "DNA Metiltransferase"
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5-Aza-2'-deoxycytidine
CAS:Fórmula:C8H12N4O4Pureza:>98.0%(HPLC)Cor e Forma:White to Almost white powder to crystalPeso molecular:228.21PR5-LL-CM01
CAS:PR5-LL-CM01 is a novel protein arginine methyltransferase 5 (PRMT5) inhibitor in colorectal and pancreatic cancers.Fórmula:C23H27N7Cor e Forma:SolidPeso molecular:401.51AZ505 ditrifluoroacetate
CAS:AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).Fórmula:C33H40Cl2F6N4O8Cor e Forma:SolidPeso molecular:805.59(R)-GSK-3685032
CAS:(R)-GSK-3685032 is a selective, reversible DNMT1 inhibitor, non-covalent, IC50: 0.036 μM; reduces DNA methylation, inhibits cancer growth.Fórmula:C22H24N6OSCor e Forma:SolidPeso molecular:420.54AS-85
CAS:AS-85 is an ASH1L inhibitor with anti-leukemic activity that inhibits leukemic cell growth and increases cLogP.Fórmula:C26H28F3N5O3S2Pureza:98.96%Cor e Forma:SolidPeso molecular:579.66EPZ020411
CAS:EPZ020411 is a specific and effective inhibitor of PRMT6 (IC50=10 nM).Fórmula:C25H38N4O3Cor e Forma:SolidPeso molecular:442.6Tazemetostat hydrobromide
CAS:Tazemetostat hydrobromide: potent, selective EZH2 inhibitor; blocks PRC2/wild-type EZH2 (Ki: 2.5 nM) & EZH1 (IC50: 392 nM).Fórmula:C34H45BrN4O4Pureza:99.8%Cor e Forma:SolidPeso molecular:653.65SGC0946
CAS:<p>SGC0946 is a highly effective and specific DOT1L methyltransferase inhibitor (IC50: 0.3 nM); selectively kill mixed lineage leukemia cells.</p>Fórmula:C28H40BrN7O4Pureza:98% - 99.82%Cor e Forma:SolidPeso molecular:618.57SGC2085 HCl
CAS:<p>SGC2085: potent, selective CARM1 inhibitor; IC50=50 nM; >100x selectivity vs other PRMTs; impacts cancer growth.</p>Fórmula:C19H24N2O2·HClPureza:99.91%Cor e Forma:SolidPeso molecular:348.87UNC0646
CAS:UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP with low cellular toxicity.Fórmula:C36H59N7O2Pureza:>99.99%Cor e Forma:SolidPeso molecular:621.9AZ505
CAS:AZ505 is an effective and specific SMYD2 inhibitor (IC50: 0.12 μM).Fórmula:C29H38Cl2N4O4Pureza:98.18%Cor e Forma:SolidPeso molecular:577.54Gambogenic acid
CAS:Gambogenic acid is a natural product,is an effective inhibitor of EZH2,with anticancer activity.Fórmula:C38H46O8Pureza:97.47% - 99.6%Cor e Forma:SolidPeso molecular:630.77C-7280948
CAS:C-7280948 is a PRMT1 inhibitor.Fórmula:C14H16N2O2SPureza:99.55% - ≥95%Cor e Forma:SolidPeso molecular:276.35WDR5-0103
CAS:WDR5-0103 (WD-Repeat Protein 5-0103) is an effective and specific WD repeat-containing protein 5 (WDR5) antagonist (Kd: 450 nM).Fórmula:C21H25N3O4Pureza:98% - 99.61%Cor e Forma:SolidPeso molecular:383.44Piribedil
CAS:Piribedil (Trivastan) is a dopamine D2 agonist, used in the treatment of Parkinson's disease.Fórmula:C16H18N4O2Pureza:99.79% - 99.82%Cor e Forma:SolidPeso molecular:298.34A-196
CAS:A-196 is a potent and selective inhibitor of SUV420 h1 and SUV420 h2 with IC50 values of 0.025 and 0.144 μM, respectively; more than 100-fold selective overFórmula:C18H16Cl2N4Pureza:99.92%Cor e Forma:SolidPeso molecular:359.25UNC0642
CAS:UNC0642 is an effective and specific G9a/GLP inhibitor (IC50< 2.5 nM).Fórmula:C29H44F2N6O2Pureza:98.75% - 99.5%Cor e Forma:SolidPeso molecular:546.7EPZ005687
CAS:EPZ005687 is a potent and selective inhibitor of EZH2.Fórmula:C32H37N5O3Pureza:97.06% - 99.64%Cor e Forma:SolidPeso molecular:539.67EED226
CAS:<p>EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.</p>Fórmula:C17H15N5O3SPureza:98.14% - 99.33%Cor e Forma:SolidPeso molecular:369.4CM-579 trihydrochloride
CM-579 trihydrochloride: reversible G9a/DNMT inhibitor with IC50s 16 nM (G9a) & 32 nM (DNMT); potent against various cancer cells.Fórmula:C29H43Cl3N4O3Cor e Forma:SolidPeso molecular:602.04
