Receptor de Androgénio
O receptor de andrógenos (AR) é um receptor hormonal nuclear que é ativado pela ligação a andrógenos, como a testosterona e a diidrotestosterona. Este receptor desempenha um papel crucial no desenvolvimento e na manutenção das características masculinas, bem como na regulação de vários processos fisiológicos, incluindo o crescimento muscular, a libido e a densidade óssea. Inibidores do receptor de andrógenos são amplamente estudados no contexto do câncer de próstata, onde a sinalização do AR é frequentemente aumentada. Na CymitQuimica, oferecemos uma gama de moduladores do receptor de andrógenos de alta qualidade para apoiar sua pesquisa em endocrinologia, biologia do câncer e regulação hormonal.
Foram encontrados 237 produtos para "Receptor de Androgénio".
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ARD-2051
CAS:ARD-2051 is a potent, orally active AR PROTAC degrader with a DC50 of 0.6 nM in LNCaP and VCaP cells, useful for prostate cancer research.Fórmula:C43H45ClN8O5Pureza:98%Cor e Forma:SolidPeso molecular:789.32MTX-23
CAS:MTX-23, an AR-targeted Proteolysis Targeting Chimera (PROTAC), effectively degrades both AR-V7 and AR-FL, inhibiting the proliferation of CaP cells and inducingFórmula:C43H53F2N7O7S2Cor e Forma:SolidPeso molecular:882.05AR ligand-33
AR ligand-33 is a ligand for the androgen receptor (AR), and it can be used as a target protein ligand for the synthesis of PROTAC AR Degrader-8.Fórmula:C25H28N2O3Cor e Forma:SolidPeso molecular:404.501Lambertianic acid
CAS:Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects.Fórmula:C20H28O3Pureza:98%Cor e Forma:SolidPeso molecular:316.441LO-4-25
LO-4-25 is a covalent degrader targeting the androgen receptor (AR) and its splice variant AR-V7. It covalently binds to the E3 ubiquitin ligase CUL4 DCAF16, facilitating the ubiquitination of both AR and AR-V7, which are then recognized and degraded by the proteasome, leading to reduced protein levels of AR and AR-V7 in cells. LO-4-25 is promising for research on androgen-independent prostate cancer.Cor e Forma:Odour Solid6-Amino-5-bromoquinoxaline
CAS:6-Amino-5-bromoquinoxaline ,with CAS No. 50358-63-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Amino-5-bromoquinoxaline provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C8H6BrN3Cor e Forma:Yellow SolidPeso molecular:224.052-sec-Butylphenol
CAS:2-sec-Butylphenol is an inhibitor of the androgen receptor and P450 aromatase, and can be used in research and experiments in the field of life sciences.Fórmula:C10H14OCor e Forma:SolidPeso molecular:150.22ARCC-4
CAS:ARCC-4: A VHL-recruiting, low-nanomolar (DC50=5nM) AR degrader; outshines enzalutamide; degrades AR mutants resistant to therapy.Fórmula:C53H56F3N7O7S2Pureza:98%Cor e Forma:SolidPeso molecular:1024.18Cl-4AS-1
CAS:steroidal androgen receptor agonistFórmula:C26H33ClN2O2Pureza:98%Cor e Forma:SolidPeso molecular:441.01RLA-4842
RLA-4842: iron-based anti-androgen; inhibits mCRPC cell proliferation.Fórmula:C42H46F3N5O8SCor e Forma:SolidPeso molecular:837.9PROTAC AR Degrader-9
PROTAC AR Degrader-9 (Compound c6) is a PROTAC-based degrader specifically targeting the androgen receptor. It effectively degrades the androgen receptor in human dermal papilla cells (HDPC) with a DC50 of 262.38 nM. Additionally, this compound enhances the expression of paracrine factors, such as TGF-β1 and β-catenin, thereby promoting hair regeneration in mouse models. [Pink: ligand for target protein AR ligand-38; Black: linker; Blue: ligand for E3 ligase Cereblon]Fórmula:C43H49ClN6O5Cor e Forma:SolidPeso molecular:765.339RLA-5331
RLA-5331: iron activator with anti-androgen properties; inhibits mCRPC cell proliferation.Fórmula:C40H43F3N6O7SCor e Forma:SolidPeso molecular:808.87PROTAC AR-V7 degrader-1
CAS:Potent, oral AR-V7 degrader (Compound 6); DC50: 0.32µM; targets AR-DBD via VHL E3; EC50: 0.88µM in 22Rv1 cells.Fórmula:C41H52N6O6S2Cor e Forma:SolidPeso molecular:789.02Dipropyl phthalate
CAS:Dipropyl phthalate is a weak androgen receptor inhibitor, and can be used in biochemical experiments and drug synthesis.Fórmula:C14H18O4Pureza:98.62%Cor e Forma:SolidPeso molecular:250.29Linuron
CAS:Produto ControladoLinuron herbicide disrupts photosynthesis and acts as an androgen receptor antagonist.Fórmula:C9H10Cl2N2O2Pureza:99.08%Cor e Forma:SolidPeso molecular:249.09ARD-61
CAS:ARD-61: potent PROTAC, degrades AR/PR in AR+ cancers, triggers apoptosis, inhibits tumor growth in mice.Fórmula:C61H71ClN8O7SCor e Forma:SolidPeso molecular:1095.8VinclozolinM2-2204
VinclozolinM2-2204 is an androgen receptor AUTOTAC degrader with a DC50 of 200 nM in LNCaP prostate cancer cells. It induces the formation of AR+LC3+ autophagic membranes and is applicable for cancer research.Fórmula:C43H51Cl2N3O9Cor e Forma:SolidPeso molecular:823.30024Tibolone
CAS:Tibolone is an estrogen-like compound used for the treatment of the symptoms associated with menopausal transition (i.e., climacteric symptoms) and also for theFórmula:C21H28O2Pureza:99.70% - 99.71%Cor e Forma:White SolidPeso molecular:312.45Nuclear Receptor Compound Library
A unique collection of xnum nuclear receptor signaling targeted compounds for high throughput and high content screening;Cor e Forma:Odour SolidRef: TM-L1510
1mgA consultar10μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultarAdrenocorticotropic hormone
CAS:Adrenocorticotropic hormone (ACTH) regulates cortisol/androgens, promotes sperm development, and alleviates gout inflammation via M1/ROS inhibition.Cor e Forma:Solid
